{
  "name": "H2Medizin",
  "language": "de",
  "url": "https://h2medizin.org",
  "other_language_url": "https://h2medicine.org",
  "description": "Wissenschaftliche Evidenz-Übersicht zu molekularem Wasserstoff (H₂) am Menschen — keine medizinische Beratung. Null- und Negativergebnisse sind enthalten.",
  "license": "Study metadata compiled from public sources (PubMed, CrossRef). Facts, freely reusable with attribution.",
  "endpoints": {
    "meta": "https://h2medizin.org/api/meta.json",
    "catalog": "https://h2medizin.org/api/catalog.json",
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    "llms": "https://h2medizin.org/llms.txt"
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  "human": 212,
  "therapeutic": 144,
  "by_evidence_level": {
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    "2": 148,
    "3": 64,
    "4": 169
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    {
      "pmid": "42050215",
      "year": 2026,
      "title": "Die wesentliche Rolle des Wasserstoffgas-Recyclings durch Darmmikroben bei der Reduzierung der Deuterium-Last in den Mitochondrien des Wirts: Ist Trimethylaminoxid ein Deuterium-Sensor?",
      "title_en": "The essential role of hydrogen gas recycling by gut microbes in reducing deuterium load in host mitochondria: is trimethylamine oxide a deuterium sensor?",
      "title_de": null,
      "journal": "Metabolomics : Official journal of the Metabolomic Society",
      "authors": "Seneff et al.",
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      "doi": "10.1007/s11306-026-02443-3",
      "doi_url": "https://doi.org/10.1007/s11306-026-02443-3",
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      "url": "https://h2medizin.org/studien/studie-seneff-2026-wesentliche-rolle-des-wasserstoffgas/",
      "methods": [
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        "metabolic",
        "liver",
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        "cardiovascular",
        "cancer",
        "oxidative-stress"
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      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41747800",
      "year": 2026,
      "title": "Die schützenden Wirkungen von molekularem Wasserstoff bei sepsisassoziierter Enzephalopathie: aktueller Stand.",
      "title_en": "The protective effects of molecular hydrogen in sepsis-associated encephalopathy: current status.",
      "title_de": null,
      "journal": "European journal of pharmacology",
      "authors": "Dumbuya et al.",
      "author_search": "dumbuya dumbuya",
      "doi": "10.1016/j.ejphar.2026.178693",
      "doi_url": "https://doi.org/10.1016/j.ejphar.2026.178693",
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      "url": "https://h2medizin.org/studien/studie-dumbuya-2026-schuetzenden-sepsisassoziierter-enzephalopathie-aktueller/",
      "methods": [
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        "immune-system",
        "oxidative-stress"
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    {
      "pmid": "41641928",
      "year": 2026,
      "title": "Neue Fortschritte bei wasserstoff-synergistischen diagnostischen und therapeutischen Nanoplattformen für die Tumorbehandlung.",
      "title_en": "New progress in hydrogen-synergistic diagnostic and therapeutic nanoplatforms for tumor treatment.",
      "title_de": null,
      "journal": "Biomaterials science",
      "authors": "Shi et al.",
      "author_search": "shi shi",
      "doi": "10.1039/d5bm01802a",
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      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41641928/",
      "url": "https://h2medizin.org/studien/studie-shi-2026-neue-fortschritte-synergistischen-diagnostischen/",
      "methods": [
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    {
      "pmid": "41496215",
      "year": 2026,
      "title": "Erneute Betrachtung der molekularen Wasserstoff-Signalübertragung in Mitochondrien: Ist das Rieske-Protein der Eintrittspunkt oder ein nachgeschalteter Wächter?",
      "title_en": "Revisiting molecular hydrogen signaling in mitochondria: Is the Rieske protein the entry point or a downstream sentinel?",
      "title_de": null,
      "journal": "Redox biology",
      "authors": "Ostojic",
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      "doi": "10.1016/j.redox.2026.104003",
      "doi_url": "https://doi.org/10.1016/j.redox.2026.104003",
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      "url": "https://h2medizin.org/studien/studie-ostojic-2026-erneute-betrachtung-molekularen-signaluebertragung/",
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      "h2category": "review"
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    {
      "pmid": "41482991",
      "year": 2026,
      "title": "Medizinische Gase als aufkommende Regulatoren pädiatrischer endokriner und neuronaler Entwicklungspfade: Ein Mini-Review",
      "title_en": "Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini-Review.",
      "title_de": null,
      "journal": "Acta paediatrica (Oslo, Norway : 1992)",
      "authors": "Paparella et al.",
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      "doi": "10.1111/apa.70429",
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      "url": "https://h2medizin.org/studien/studie-paparella-2026-medizinische-gase-aufkommende-regulatoren/",
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        "eye",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
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    {
      "pmid": "41449652",
      "year": 2026,
      "title": "Aufkommende klinische Anwendungen für molekularen Wasserstoff",
      "title_en": "Emerging Clinical Applications for Molecular Hydrogen.",
      "title_de": null,
      "journal": "Respiratory care",
      "authors": "Nguyen Puente et al.",
      "author_search": "nguyen puente nguyen puente",
      "doi": "10.1177/19433654251398759",
      "doi_url": "https://doi.org/10.1177/19433654251398759",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41449652/",
      "url": "https://h2medizin.org/studien/studie-nguyenpuente-2026-aufkommende-klinische-anwendungen-molekularen/",
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        "cardiovascular",
        "cancer",
        "respiratory",
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        "immune-system",
        "oxidative-stress"
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      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41260719",
      "year": 2026,
      "title": "Gastherapien zur Neuroprotektion",
      "title_en": "Gas Therapies for Neuro-Protection.",
      "title_de": null,
      "journal": "Critical care clinics",
      "authors": "Merigo et al.",
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      "doi": "10.1016/j.ccc.2025.08.004",
      "doi_url": "https://doi.org/10.1016/j.ccc.2025.08.004",
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      "url": "https://h2medizin.org/studien/studie-merigo-2026-gastherapien-zur-neuroprotektion/",
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        "immune-system",
        "oxidative-stress"
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      "therapeutic": false,
      "h2category": "review"
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    {
      "pmid": "41232804",
      "year": 2026,
      "title": "Fortschritte bei Strategien zur Wasserstoff-Verabreichung für therapeutische Anwendungen",
      "title_en": "Advances in hydrogen delivery strategies for therapeutic applications.",
      "title_de": null,
      "journal": "Advanced drug delivery reviews",
      "authors": "Nguyen et al.",
      "author_search": "nguyen nguyen",
      "doi": "10.1016/j.addr.2025.115734",
      "doi_url": "https://doi.org/10.1016/j.addr.2025.115734",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41232804/",
      "url": "https://h2medizin.org/studien/studie-nguyen-2026-fortschritte-strategien-zur-verabreichung/",
      "methods": [
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        "saline-iv",
        "drinking-hrw"
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        "cancer",
        "skin-aging",
        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
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      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41144865",
      "year": 2026,
      "title": "Stimuli-responsive Wasserstoffproduktion aus Nanomaterialien: Design, Regulation und biomedizinische Anwendungen",
      "title_en": "Stimuli-Responsive Hydrogen Production from Nanomaterials: Design, Regulation and Biomedical Applications.",
      "title_de": null,
      "journal": "Advanced healthcare materials",
      "authors": "Pan et al.",
      "author_search": "pan pan",
      "doi": "10.1002/adhm.202503077",
      "doi_url": "https://doi.org/10.1002/adhm.202503077",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41144865/",
      "url": "https://h2medizin.org/studien/studie-pan-2026-stimuli-responsive-wasserstoffproduktion-aus/",
      "methods": [
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        "cardiovascular",
        "cancer",
        "skin-aging",
        "immune-system",
        "fundamentals-safety"
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      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "40826940",
      "year": 2026,
      "title": "Molekularer Wasserstoff und Nierenerkrankungen: eine Scoping-Review auf Basis von Szientometrie und Datenanalytik",
      "title_en": "Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics.",
      "title_de": null,
      "journal": "Medical gas research",
      "authors": "Viana et al.",
      "author_search": "viana viana",
      "doi": "10.4103/mgr.medgasres-d-25-00047",
      "doi_url": "https://doi.org/10.4103/mgr.medgasres-d-25-00047",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40826940/",
      "url": "https://h2medizin.org/studien/studie-viana-2026-nierenerkrankungen-scoping-review-basis/",
      "methods": [
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        "immune-system",
        "oxidative-stress"
      ],
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      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "41401441",
      "year": 2026,
      "title": "Sechzigminütige Inhalation von molekularem Wasserstoff senkt die Blutsauerstoffsättigung, verändert aber die autonome Herzregulation in Ruhe bei gesunden Frauen nicht: eine randomisierte, doppelblinde, placebokontrollierte Crossover-Studie",
      "title_en": "Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: a randomized, double-blind, placebo-controlled crossover study",
      "title_de": null,
      "journal": "Canadian Journal of Physiology and Pharmacology",
      "authors": "Grepl et al.",
      "author_search": "grepl grepl",
      "doi": "10.1139/cjpp-2025-0228",
      "doi_url": "https://doi.org/10.1139/cjpp-2025-0228",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41401441/",
      "url": "https://h2medizin.org/studien/studie-grepl-2026-60-minuten-inhalation-blutsauerstoffsaettigung-herzregulation/",
      "methods": [
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      "indications": [
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        "cardiovascular",
        "womens-health"
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      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "41754211",
      "year": 2026,
      "title": "Der Konsum von Redox-Wasser dämpft belastungsbedingte Entzündung und oxidativen Stress bei körperlich aktiven Erwachsenen: eine randomisierte kontrollierte Studie",
      "title_en": "Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial",
      "title_de": null,
      "journal": "Nutrients",
      "authors": "Stolecka-Warzecha et al.",
      "author_search": "stolecka-warzecha stolecka-warzecha",
      "doi": "10.3390/nu18040694",
      "doi_url": "https://doi.org/10.3390/nu18040694",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41754211/",
      "url": "https://h2medizin.org/studien/studie-stolecka-warzecha-2026-redox-wasser-belastungs-entzuendung-oxidativer-stress/",
      "methods": [
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      "indications": [
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        "oxidative-stress",
        "immune-system"
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      "evidence_level": 3,
      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "41545661",
      "year": 2026,
      "title": "Explorative Evaluation einer Therapie mit wasserstoffreichem Wasser zur Behandlung von Keloiden: eine doppelblinde, randomisierte Pilotstudie",
      "title_en": "Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial",
      "title_de": null,
      "journal": "Aesthetic Plastic Surgery",
      "authors": "Kuang et al.",
      "author_search": "kuang kuang",
      "doi": "10.1007/s00266-025-05512-5",
      "doi_url": "https://doi.org/10.1007/s00266-025-05512-5",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41545661/",
      "url": "https://h2medizin.org/studien/studie-kuang-2026-keloide-pilotstudie/",
      "methods": [
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        "oxidative-stress",
        "immune-system"
      ],
      "evidence_level": 3,
      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "41859790",
      "year": 2026,
      "title": "Der kombinierte Einsatz von inhaliertem Stickstoffmonoxid und molekularem Wasserstoff bei Patienten mit Post-COVID-19-Syndrom",
      "title_en": "The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome",
      "title_de": null,
      "journal": "Terapevticheskii arkhiv",
      "authors": "Pozdnyakova et al.",
      "author_search": "pozdnyakova pozdnyakova",
      "doi": "10.26442/00403660.2026.03.203537",
      "doi_url": "https://doi.org/10.26442/00403660.2026.03.203537",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41859790/",
      "url": "https://h2medizin.org/studien/studie-pozdnyakova-2026-inhaliertes-stickstoffmonoxid-post-covid-19-syndrom/",
      "methods": [
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        "bath-topical"
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        "oxidative-stress",
        "immune-system"
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      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "42139605",
      "year": 2026,
      "title": "Hydratations-Bioanalysen der Wirkungen von wasserstoffreichem Wasser (HRW)",
      "title_en": "Hydration bioanalyses of the effects of hydrogen-rich water (HRW).",
      "title_de": null,
      "journal": "Wiadomosci lekarskie (Warsaw, Poland : 1960)",
      "authors": "Pesotskaya et al.",
      "author_search": "pesotskaya pesotskaya",
      "doi": "10.36740/wlek/218738",
      "doi_url": "https://doi.org/10.36740/wlek/218738",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/42139605/",
      "url": "https://h2medizin.org/studien/studie-pesotskaya-2026-hydratations-bioanalysen-wasserstoffreichem-hrw/",
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      "human": true,
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    },
    {
      "pmid": "42049414",
      "year": 2026,
      "title": "Adjunktive Therapie mit molekularem Wasserstoff in Kapselform bei Empyem mit komplizierender chronischer inflammatorischer demyelinisierender Polyneuropathie: Ein Fallbericht",
      "title_en": "Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.21873/invivo.14337",
      "doi_url": "https://doi.org/10.21873/invivo.14337",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/42049414/",
      "url": "https://h2medizin.org/studien/studie-li-2026-adjunktive-kapselform-empyem-komplizierender/",
      "methods": [
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        "respiratory",
        "immune-system",
        "oxidative-stress"
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      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "42049119",
      "year": 2026,
      "title": "Wasserstoffgas-Inhalation linderte zerebrale Ischämie-/Reperfusionsschäden durch Regulierung der Mitophagie in SH-SY5Y-Zellen und Mäusen über den PTEN-induzierten Kinase-1/Parkin-Signalweg.",
      "title_en": "Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.",
      "title_de": null,
      "journal": "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.jstrokecerebrovasdis.2026.108645",
      "doi_url": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108645",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/42049119/",
      "url": "https://h2medizin.org/studien/studie-wang-2026-wasserstoffgas-inhalation-linderte-zerebrale/",
      "methods": [
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        "cardiovascular",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "42035551",
      "year": 2026,
      "title": "Molekularer Wasserstoff unterdrückt Darmentzündung und Pyroptose bei Colitis ulcerosa durch Förderung der PKM2-Laktylierung zur Blockierung der NLRP3-Inflammasom-Aktivierung.",
      "title_en": "Molecular hydrogen suppresses gut inflammation and pyroptosis in ulcerative colitis through promoting PKM2 lactylation to block NLRP3 inflammasome activation.",
      "title_de": null,
      "journal": "International immunopharmacology",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.1016/j.intimp.2026.116726",
      "doi_url": "https://doi.org/10.1016/j.intimp.2026.116726",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/42035551/",
      "url": "https://h2medizin.org/studien/studie-yang-2026-unterdrueckt-darmentzuendung-pyroptose-colitis/",
      "methods": [
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        "fundamentals-safety"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41986239",
      "year": 2026,
      "title": "Selbstadaptives Wasserstoff-Nanoabgabesystem im Glaukom-Management: Eine synergistische antioxidative und entzündungshemmende therapeutische Strategie",
      "title_en": "Self-Adaptive Hydrogen Nano-Delivery System in Glaucoma Management: Synergistic Antioxidation and Anti-inflammation Therapeutic Strategy.",
      "title_de": null,
      "journal": "ACS nano",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.1021/acsnano.6c01611",
      "doi_url": "https://doi.org/10.1021/acsnano.6c01611",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41986239/",
      "url": "https://h2medizin.org/studien/studie-zhu-2026-selbstadaptives-nanoabgabesystem-glaukom-management/",
      "methods": [
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      "indications": [
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        "eye",
        "immune-system",
        "oxidative-stress"
      ],
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      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41931901",
      "year": 2026,
      "title": "Optimierung der Linsengröße und der Ionenquellenparameter für gaschromatographie-/massenspektrometriebasierte Metabolomik unter Verwendung von Wasserstoff als Trägergas",
      "title_en": "Optimization of lens size and ion source parameters for gas chromatography/mass spectrometry-based metabolomics using hydrogen as a carrier gas.",
      "title_de": null,
      "journal": "Journal of chromatography. A",
      "authors": "Sato et al.",
      "author_search": "sato sato",
      "doi": "10.1016/j.chroma.2026.466945",
      "doi_url": "https://doi.org/10.1016/j.chroma.2026.466945",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41931901/",
      "url": "https://h2medizin.org/studien/studie-sato-2026-optimierung-linsengroesse-ionenquellenparameter-gaschromatographie/",
      "methods": [
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      "indications": [
        "cancer"
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      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "41923649",
      "year": 2026,
      "title": "Die abgewandte Seite der Carborane: antikanzerogen aktive Monokationen und umgebungsstabile Dikationen",
      "title_en": "The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications.",
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      "journal": "Angewandte Chemie (International ed. in English)",
      "authors": "Němec et al.",
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      "url": "https://h2medizin.org/studien/studie-nemec-2026-abgewandte-seite-carborane-antikanzerogen/",
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      "year": 2026,
      "title": "Wasserstoffangereicherter Hyaluronsäure-Wundverband verbessert das diabetische Fußulkus durch Förderung der Mitophagie",
      "title_en": "Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy.",
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      "journal": "Journal of diabetes",
      "authors": "Xu et al.",
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      "doi": "10.1111/1753-0407.70209",
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      "pmid": "41799190",
      "year": 2026,
      "title": "Molekularer Wasserstoff löst TRPC4-TRPC4AP-abhängige reversible Calcium-Transienten über extrazellulären Einstrom aus",
      "title_en": "Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx.",
      "title_de": null,
      "journal": "Theranostics",
      "authors": "Zhao et al.",
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      "doi": "10.7150/thno.124352",
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      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41799190/",
      "url": "https://h2medizin.org/studien/studie-zhao-2026-loest-trpc4-trpc4ap-abhaengige/",
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      "pmid": "41760342",
      "year": 2026,
      "title": "Adjunktive Therapie mit molekularem Wasserstoff moduliert T-Zell-Marker und reduziert Anti-Ro-Antikörper bei refraktären oralen Ulzera des Morbus Behçet und des Sjögren-Syndroms: Ein Fallbericht",
      "title_en": "Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report.",
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      "journal": "In vivo (Athens, Greece)",
      "authors": "Lin et al.",
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      "doi": "10.21873/invivo.14274",
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      "url": "https://h2medizin.org/studien/studie-lin-2026-adjunktive-moduliert-zell-marker/",
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    {
      "pmid": "41752368",
      "year": 2026,
      "title": "Ru-basierte NSAR als potenzielle antikanzerogene Therapeutika",
      "title_en": "Ru-Based NSAIDs as Potential Anticancer Therapeutics.",
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      "journal": "Molecules (Basel, Switzerland)",
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      "pmid": "41749059",
      "year": 2026,
      "title": "Transkriptombasierte Bewertung der Wirkungen von Wasserstoffgas zur Vorbeugung von UVA-induzierter Photoalterung anhand eines künstlichen Hautmodells",
      "title_en": "Transcriptome-Based Evaluation of Hydrogen Gas Effects for Preventing UVA-Induced Photoaging Using an Artificial Skin Model.",
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      "journal": "Geriatrics & gerontology international",
      "authors": "Kiyoi et al.",
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      "doi": "10.1111/ggi.70401",
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      "url": "https://h2medizin.org/studien/studie-kiyoi-2026-transkriptombasierte-bewertung-wasserstoffgas-zur/",
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    {
      "pmid": "41709731",
      "year": 2026,
      "title": "MXene-konstruierte MgB₂-Nanoprodrugs mit säureresponsiver Wasserstoffentwicklung für kooperative photothermische Krebsablation",
      "title_en": "MXene-Engineered MgB2 Nanoprodrugs with Acid-Responsive Hydrogen Evolution for Cooperative Photothermal Cancer Ablation.",
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      "journal": "ACS applied materials & interfaces",
      "authors": "Li et al.",
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      "doi": "10.1021/acsami.5c25581",
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      "url": "https://h2medizin.org/studien/studie-li-2026-mxene-konstruierte-mgb2-nanoprodrugs/",
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      "pmid": "41702867",
      "year": 2026,
      "title": "Elektrolysiertes Wasserstoffwasser verbessert die Chemosensitivität gegenüber Antikrebsmedikamenten durch starke Unterdrückung der Autophagie",
      "title_en": "Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy.",
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      "journal": "Journal of cellular and molecular medicine",
      "authors": "Yano et al.",
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      "doi": "10.1111/jcmm.71011",
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      "url": "https://h2medizin.org/studien/studie-yano-2026-elektrolysiertes-wasserstoffwasser-verbessert-chemosensitivitaet/",
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      "pmid": "41697782",
      "year": 2026,
      "title": "Sub-Nano-Molybdänoxid-Nanoringe als Sonosensibilisatoren mit verstärkter atomarer Effizienz für hocheffiziente sonodynamische Tumorablation",
      "title_en": "Sub-nano molybdenum oxide nanorings as amplified atomic efficiency sonosensitizers for highly efficient sonodynamic tumor ablation.",
      "title_de": null,
      "journal": "Nanoscale",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1039/d5nr05289k",
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      "url": "https://h2medizin.org/studien/studie-zhang-2026-sub-nano-molybdaenoxid-nanoringe/",
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      "pmid": "41655909",
      "year": 2026,
      "title": "Ein Wasserstoffgenerator verstärkt die immunogene transarterielle Chemoembolisation beim hepatozellulären Karzinom",
      "title_en": "A hydrogen generator enhances immunogenic transarterial chemoembolization in hepatocellular carcinoma.",
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      "authors": "Cao et al.",
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      "doi": "10.1016/j.jconrel.2026.114694",
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      "pmid": "41582106",
      "year": 2026,
      "title": "Wasserstoff-Inhalation ist mit einer vorübergehenden rechtsgerichteten Verschiebung der präfrontalen Oxyhämoglobin-Asymmetrie und autonomer Modulation assoziiert",
      "title_en": "Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.",
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      "pmid": "41580925",
      "year": 2026,
      "title": "Synergistische Calcium-Überladung und Wasserstofffreisetzung verstärken eine robuste Antitumor-Immunität",
      "title_en": "Synergistic Calcium Overload and Hydrogen Release Potentiate Robust Antitumor Immunity.",
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      "journal": "Advanced healthcare materials",
      "authors": "Liang et al.",
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      "doi": "10.1002/adhm.202505332",
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      "pmid": "41533764",
      "year": 2026,
      "title": "Wasserstoff lindert psoriasisartige Hautentzündung durch Hemmung des cGAS-STING-Signalwegs",
      "title_en": "Hydrogen ameliorates psoriasis-like skin inflammation via inhibiting the cGAS-STING pathway.",
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      "authors": "Wu et al.",
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      "doi": "10.1093/cei/uxaf081",
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      "pmid": "41482402",
      "year": 2026,
      "title": "Rhupus-Syndrom mit multiplen Arzneimittelunverträglichkeiten, behandelt mit dosisreduziertem Rituximab und adjunktiver Therapie mit molekularem Wasserstoff: Ein Fallbericht",
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      "journal": "In vivo (Athens, Greece)",
      "authors": "Tsai et al.",
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      "pmid": "41482388",
      "year": 2026,
      "title": "Adjuvante Therapie mit molekularem Wasserstoff bei SLE-assoziierter pulmonalarterieller Hypertonie: Ein Fallbericht über immunmodulatorische Effekte auf regulatorische und Effektor-Lymphozyten",
      "title_en": "Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.",
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      "journal": "In vivo (Athens, Greece)",
      "authors": "Liu et al.",
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      "doi": "10.21873/invivo.14220",
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      "title": "Perlenartige bioinspirierte Beschichtung ermöglicht die Regulierung des Mg-Abbaus für die osteoporotische Knochenheilung",
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      "title_de": null,
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
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      "title": "Therapeutisches Potenzial von Magnesiumdiborid-Nanoblättern bei PAH-assoziierter Rechtsherzinsuffizienz: Integrierte Multi-Omics-Analyse zeigt Ferroptose-Unterdrückung über den LC3/ATG5/NCOA4/FTH1-Signalweg",
      "title_en": "Therapeutic potential of magnesium diboride nanosheets in PAH-associated right heart failure: Integrated multi-omics analysis reveals ferroptosis suppression via LC3/ATG5/NCOA4/FTH1 pathway.",
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      "title": "Synergistisches Strecken-Tempern und Aussalzen ermöglichen ultrastarke, ultrazähe anisotrope leitfähige Hydrogele aus bakterieller Cellulose für bioelektrische Sensoren",
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      "year": 2026,
      "title": "Tumormikroumgebungs-responsive wasserstofferzeugende Zn-dotierte ReZIF-8-Nanoplattform zur verstärkten Tumorunterdrückung",
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      "journal": "Advanced healthcare materials",
      "authors": "Qin et al.",
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      "doi": "10.1002/adhm.202502489",
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      "title": "Mechanismen und Schutzstrategien für Hautverletzungen von Astronauten in Tiefraumumgebungen",
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      "journal": "Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences",
      "authors": "Xie et al.",
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    {
      "pmid": "41373725",
      "year": 2025,
      "title": "Erkundung des Potenzials von molekularem Wasserstoff in verschiedenen Herzinsuffizienz-Modellen: Eine Übersichtsarbeit",
      "title_en": "Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review.",
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      "authors": "Kornieieva et al.",
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    {
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      "title": "Innovationen bei Peritonealdialyse-Flüssigkeit: biokompatible Formulierungen und erweiterte therapeutische Anwendungen",
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    {
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      "title": "Molekulare Mechanismen im Zusammenhang mit den Wirkungen des Wasserstoffmoleküls bei Lebererkrankungen: eine Übersicht der aktuellen Evidenz",
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    {
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      "title": "Verabreichung von molekularem Wasserstoff zur präzisen Immunmodulation: Mechanismen, Nachweismethoden und Anwendungen",
      "title_en": "Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications.",
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      "title": "Molekularer Wasserstoff als neuartiger Regulator der zellulären Pyroptose: mechanistische Einblicke und therapeutische Implikationen",
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      "title": "Therapie mit molekularem Wasserstoff: Eine „demokratische” aufkommende Strategie gegen Alterung und altersbedingte Erkrankungen",
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    {
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      "title": "Antioxidative Therapien als aufkommende adjunktive Behandlungen bei rheumatoider Arthritis: Oxidativer Stress als Zielstruktur zur Verbesserung der Behandlungsergebnisse",
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      "title": "Molekularer Wasserstoff: Mechanismus gegen oxidativen Stress und Anwendung bei Parodontitis: Eine Übersichtsarbeit",
      "title_en": "Molecular hydrogen: Mechanism against oxidative stress and application in periodontitis: A review.",
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      "title": "Alterung, vaskuläre Dysfunktion und die Blut-Hirn-Schranke: Aufdeckung der Pathophysiologie des Schlaganfalls bei älteren Erwachsenen",
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      "title": "Die Rolle der Neuroinflammation bei L-DOPA-induzierter Dyskinesie: Aufschlüsselung der Rollen von NF-κB und TNF-α für neuartige pharmakologische therapeutische Ansätze",
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    {
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      "title": "Erkundung des Potenzials der H₂-Therapie zur Reduzierung chirurgischer Komplikationen: Eine Übersichtsarbeit über entzündungshemmende, antioxidative und antifibrotische Mechanismen",
      "title_en": "Exploring the Potential of H2 Therapy in Reducing Surgical Complications: A Review on Anti-inflammatory, Antioxidant, and Anti-fibrotic Mechanisms.",
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    {
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      "title": "Orale Verabreichung von wasserstoffreichem Wasser: Biomedizinische Aktivitäten, mögliche Mechanismen und klinische Anwendungen",
      "title_en": "Oral Administration of Hydrogen-rich Water: Biomedical Activities, Potential Mechanisms, and Clinical Applications.",
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      "title": "Anwendungstrends wasserstofferzeugender Nanomaterialien zur Behandlung ROS-assoziierter Erkrankungen",
      "title_en": "Application trends of hydrogen-generating nanomaterials for the treatment of ROS-related diseases.",
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    {
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      "title": "Wasserstoff als innovatives Nootropikum bei Gesundheit und Krankheit",
      "title_en": "Hydrogen as an innovative nootropic in health and disease.",
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      "title": "Die Inhalation von molekularem Wasserstoff moduliert den Ruhe-Stoffwechsel bei gesunden Frauen: Ergebnisse einer randomisierten, doppelblinden, placebokontrollierten Crossover-Studie",
      "title_en": "Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study",
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      "title_en": "Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial",
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      "title": "Die Effekte des sechswöchigen Trinkens von wasserstoffreichem Wasser auf belastungsbezogene Biomarker bei sportungewohnten Männern und Frauen über 50 Jahren nach einem Krafttrainingsprogramm: eine randomisierte, kontrollierte Pilotstudie",
      "title_en": "The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial",
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      "authors": "Kuzmanovic et al.",
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      "title": "Die Einnahme von wasserstoffreichem Kaltwasser vor dem Sport verbessert die Ausdauerleistung und die Laktatreaktion bei Hitze",
      "title_en": "Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat",
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      "journal": "Medicina (Kaunas)",
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      "title": "Die Effekte des achtwöchigen Konsums von wasserstoffreichem Wasser auf Appetit, Körperzusammensetzung, Schlafqualität und zirkulierendes Glucagon-like Peptide-1 bei adipösen Männern und Frauen (HYDRAPPET): eine randomisierte kontrollierte Studie",
      "title_en": "The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial",
      "title_de": null,
      "journal": "Medicina (Kaunas)",
      "authors": "Todorovic et al.",
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      "doi": "10.3390/medicina61071299",
      "doi_url": "https://doi.org/10.3390/medicina61071299",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40731927/",
      "url": "https://h2medizin.org/studien/studie-todorovic-2025-8-wochen-appetit-koerperzusammensetzung-schlaf-glp-1-adipoes/",
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      "human": true,
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    {
      "pmid": "40922182",
      "year": 2025,
      "title": "Die Supplementierung mit wasserstoffreichem Wasser dämpft oxidativen Stress und Entzündung bei Patienten mit chronischer Höhenkrankheit: eine doppelblinde, randomisierte, placebokontrollierte Studie",
      "title_en": "Hydrogen-rich water supplementation attenuates oxidative stress and inflammation in chronic high-altitude disease patients: A double-blind randomized placebo-controlled study",
      "title_de": null,
      "journal": "Food Research International",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1016/j.foodres.2025.117118",
      "doi_url": "https://doi.org/10.1016/j.foodres.2025.117118",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40922182/",
      "url": "https://h2medizin.org/studien/studie-zhang-2025-hoehenkrankheit-oxidativer-stress-entzuendung/",
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    {
      "pmid": "41384523",
      "year": 2025,
      "title": "Wirksamkeit nichtmedikamentöser Technologien zur Steigerung der Stressresistenz bei Personen mit extremem Arbeitsprofil und Anfälligkeit für berufliches Burnout",
      "title_en": "[Effectiveness of using non-drug technologies to increase stress resistance in persons with extreme work profile and susceptible for professional burnout].",
      "title_de": null,
      "journal": "Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury",
      "authors": "Korchazhkina et al.",
      "author_search": "korchazhkina korchazhkina",
      "doi": "10.17116/kurort202510205291",
      "doi_url": "https://doi.org/10.17116/kurort202510205291",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41384523/",
      "url": "https://h2medizin.org/studien/studie-korchazhkina-2025-des-einsatzes-nichtmedikamentoeser-technologien/",
      "methods": [
        "unspecified"
      ],
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      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "40327618",
      "year": 2025,
      "title": "Effizienz und Sicherheit des kombinierten Einsatzes medizinischer Gase – thermisches Heliox, Stickstoffmonoxid und molekularer Wasserstoff – bei Patienten mit COPD-Exazerbation, respiratorischer Insuffizienz und pulmonalarterieller Hypertonie in der Post-COVID-Phase",
      "title_en": "[Efficiency and safety of the integrated use of medical gases thermal heliox, nitric oxide and molecular hydrogen in patients with exacerbation of chronic obstructive pulmonary disease complicated by hypoxemic, hypercapnic respiratory failure and secondary pulmonary arterial hypertension in the post-COVID period].",
      "title_de": null,
      "journal": "Terapevticheskii arkhiv",
      "authors": "Shogenova",
      "author_search": "shogenova shogenova",
      "doi": "10.26442/00403660.2025.03.203131",
      "doi_url": "https://doi.org/10.26442/00403660.2025.03.203131",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40327618/",
      "url": "https://h2medizin.org/studien/studie-shogenova-2025-effizienz-sicherheit-des-kombinierten/",
      "methods": [
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    {
      "pmid": "41384514",
      "year": 2025,
      "title": "Biochemische Stressmarker bei medizinischem Personal mit berufsbedingtem Burnout-Syndrom und ihre Dynamik unter Anwendung physiotherapeutischer Faktoren",
      "title_en": "[Biochemical markers of stress in medical workers with occupational burnout syndrome and their dynamics in the application of physiotherapeutic factors].",
      "title_de": null,
      "journal": "Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury",
      "authors": "Kotenko et al.",
      "author_search": "kotenko kotenko",
      "doi": "10.17116/kurort202510205217",
      "doi_url": "https://doi.org/10.17116/kurort202510205217",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41384514/",
      "url": "https://h2medizin.org/studien/studie-kotenko-2025-biochemische-stressmarker-medizinischem-personal/",
      "methods": [
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      ],
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        "sports-exercise",
        "oxidative-stress"
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      "evidence_level": 2,
      "human": true,
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    },
    {
      "pmid": "41376217",
      "year": 2025,
      "title": "Vierdimensionale datenunabhängige Akquisitions-Proteomik und -Metabolomik enthüllen Mechanismen von wasserstoffreichem Wasser am Zusanli-Punkt (ST36) gegen dreifach-negativen Brustkrebs bei Mäusen",
      "title_en": "Four-dimensional data independent acquisition proteomics and metabolomics reveal mechanisms of hydrogen-rich water at Zusanli (ST36) point against triple-negative breast cancer in mice.",
      "title_de": null,
      "journal": "Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan",
      "authors": "Jingxuan et al.",
      "author_search": "jingxuan jingxuan",
      "doi": "10.19852/j.cnki.jtcm.20250929.002",
      "doi_url": "https://doi.org/10.19852/j.cnki.jtcm.20250929.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41376217/",
      "url": "https://h2medizin.org/studien/studie-jingxuan-2025-vierdimensionale-datenunabhaengige-akquisitions-proteomik/",
      "methods": [
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        "drinking-hrw"
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        "joints-rheumatology"
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      "human": false,
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    },
    {
      "pmid": "41330217",
      "year": 2025,
      "title": "Das Rieske-Eisen-Schwefel-Protein ist ein primäres Ziel von molekularem Wasserstoff",
      "title_en": "The Rieske iron-sulfur protein is a primary target of molecular hydrogen.",
      "title_de": null,
      "journal": "Redox biology",
      "authors": "Negishi et al.",
      "author_search": "negishi negishi",
      "doi": "10.1016/j.redox.2025.103952",
      "doi_url": "https://doi.org/10.1016/j.redox.2025.103952",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41330217/",
      "url": "https://h2medizin.org/studien/studie-negishi-2025-rieske-eisen-schwefel-protein/",
      "methods": [
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      "human": false,
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    },
    {
      "pmid": "41204320",
      "year": 2025,
      "title": "Hydrogen-FAST: Studienprotokoll für inhaliertes Wasserstoffgas als adjunktive Therapie bei refraktärem Herzstillstand (ECPR)",
      "title_en": "Hydrogen's Feasibility and Safety as a Therapy in Extracorporeal Cardiopulmonary Resuscitation (Hydrogen-FAST): study protocol for a trial of inhaled hydrogen gas as an adjunctive therapy in refractory cardiac arrest.",
      "title_de": null,
      "journal": "Trials",
      "authors": "Habet et al.",
      "author_search": "habet habet",
      "doi": "10.1186/s13063-025-09217-7",
      "doi_url": "https://doi.org/10.1186/s13063-025-09217-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41204320/",
      "url": "https://h2medizin.org/studien/studie-habet-2025-machbarkeit-sicherheit-extrakorporaler-kardiopulmonaler/",
      "methods": [
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        "cardiovascular",
        "respiratory",
        "fundamentals-safety"
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      "human": true,
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    {
      "pmid": "41176039",
      "year": 2025,
      "title": "Wasserstoffverstärkte photothermische Therapie für redox-regulierte Tumorapoptose und Immun-Reprogrammierung",
      "title_en": "Hydrogen enhanced photothermal therapy for redox-regulated tumor apoptosis and immune reprogramming.",
      "title_de": null,
      "journal": "Acta biomaterialia",
      "authors": "Chu et al.",
      "author_search": "chu chu",
      "doi": "10.1016/j.actbio.2025.10.059",
      "doi_url": "https://doi.org/10.1016/j.actbio.2025.10.059",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41176039/",
      "url": "https://h2medizin.org/studien/studie-chu-2025-wasserstoffverstaerkte-photothermische-redox-regulierte/",
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    {
      "pmid": "41167690",
      "year": 2025,
      "title": "Ein Fallbericht über adjuvante Therapie mit molekularem Wasserstoff bei refraktärer rheumatoider Arthritis mit atlantoaxialer Subluxation",
      "title_en": "A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Ren et al.",
      "author_search": "ren ren",
      "doi": "10.21873/invivo.14166",
      "doi_url": "https://doi.org/10.21873/invivo.14166",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41167690/",
      "url": "https://h2medizin.org/studien/studie-ren-2025-fallbericht-adjuvante-refraktaerer-rheumatoider/",
      "methods": [
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        "skin-aging",
        "joints-rheumatology",
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        "oxidative-stress"
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      "evidence_level": 2,
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    {
      "pmid": "41167678",
      "year": 2025,
      "title": "Dynamische Immunmodulation durch Wasserstoff-Kapseltherapie bei SLE-assoziierter pulmonalarterieller Hypertonie: Ein Fallbericht",
      "title_en": "Dynamic Immunomodulation by Hydrogen Capsule Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.21873/invivo.14165",
      "doi_url": "https://doi.org/10.21873/invivo.14165",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41167678/",
      "url": "https://h2medizin.org/studien/studie-liu-2025-dynamische-immunmodulation-kapseltherapie-sle/",
      "methods": [
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        "respiratory",
        "immune-system",
        "oxidative-stress"
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      "evidence_level": 2,
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    {
      "pmid": "41083007",
      "year": 2025,
      "title": "Transdermale Wasserstofftherapie bei Psoriasis unter Verwendung von hohlraumeingebetteten doppelkonischen Mikronadeln",
      "title_en": "Transdermal hydrogen therapy for psoriasis using cavity-embedded double-conical microneedles.",
      "title_de": null,
      "journal": "Journal of controlled release : official journal of the Controlled Release Society",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.1016/j.jconrel.2025.114313",
      "doi_url": "https://doi.org/10.1016/j.jconrel.2025.114313",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41083007/",
      "url": "https://h2medizin.org/studien/studie-zhu-2025-transdermale-wasserstofftherapie-psoriasis-unter/",
      "methods": [
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        "oxidative-stress"
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    {
      "pmid": "41076526",
      "year": 2025,
      "title": "Spontan wasserstofffreisetzendes Nanoenzym lindert Osteoarthritis durch Reduktion von oxidativem Stress und Umkehrung der mitochondrialen Dysfunktion",
      "title_en": "Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal.",
      "title_de": null,
      "journal": "Journal of nanobiotechnology",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1186/s12951-025-03716-0",
      "doi_url": "https://doi.org/10.1186/s12951-025-03716-0",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41076526/",
      "url": "https://h2medizin.org/studien/studie-wang-2025-spontan-wasserstofffreisetzendes-nanoenzym-lindert/",
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      "human": false,
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    {
      "pmid": "41063273",
      "year": 2025,
      "title": "Biomechanische Analyse biologisch abbaubarer Stifte aus Magnesium, Zink und Polylactid zur Fixierung von Radiusköpfchenfrakturen",
      "title_en": "Biomechanical analysis of biodegradable magnesium, zinc, and polylactide pins for fixation of radial head fractures.",
      "title_de": null,
      "journal": "Journal of orthopaedic surgery and research",
      "authors": "Maier et al.",
      "author_search": "maier maier",
      "doi": "10.1186/s13018-025-06346-2",
      "doi_url": "https://doi.org/10.1186/s13018-025-06346-2",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41063273/",
      "url": "https://h2medizin.org/studien/studie-maier-2025-biomechanische-analyse-biologisch-abbaubarer/",
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      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "41043278",
      "year": 2025,
      "title": "Wasserstoffreiches Gas verstärkt das mitochondriale Membranpotenzial und die Erholung der Atmungsfunktion in Caco-2-Zellen nach Ischämie-Reperfusionsschaden",
      "title_en": "Hydrogen-rich gas enhances mitochondrial membrane potential and respiratory function recovery in Caco-2 cells post-ischemia-reperfusion injury.",
      "title_de": null,
      "journal": "Biochemical and biophysical research communications",
      "authors": "Seya et al.",
      "author_search": "seya seya",
      "doi": "10.1016/j.bbrc.2025.152753",
      "doi_url": "https://doi.org/10.1016/j.bbrc.2025.152753",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41043278/",
      "url": "https://h2medizin.org/studien/studie-seya-2025-verstaerkt-mitochondriale-membranpotenzial-erholung/",
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      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "41013628",
      "year": 2025,
      "title": "Forschung zur hemmenden Wirkung von Wasserstoffgas auf Eierstockkrebs und mögliche Mechanismen",
      "title_en": "Research on the inhibitory effect of hydrogen gas on ovarian cancer and potential mechanisms.",
      "title_de": null,
      "journal": "European journal of medical research",
      "authors": "Yin et al.",
      "author_search": "yin yin",
      "doi": "10.1186/s40001-025-03111-3",
      "doi_url": "https://doi.org/10.1186/s40001-025-03111-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/41013628/",
      "url": "https://h2medizin.org/studien/studie-yin-2025-forschung-zur-hemmenden-wasserstoffgas/",
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      "evidence_level": 1,
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      "h2category": "preclinical"
    },
    {
      "pmid": "40976279",
      "year": 2025,
      "title": "Hierarchische ROS-eliminierende Plattform durchbricht den Teufelskreis aus Stammzellseneszenz, Angiogenese-Stillstand und Immundysregulation bei diabetischen Wunden.",
      "title_en": "Hierarchical ROS-scavenging platform breaks vicious cycle of stem cell senescence, angiogenesis arrest, and immune dysregulation in diabetic wounds.",
      "title_de": null,
      "journal": "Journal of controlled release : official journal of the Controlled Release Society",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.jconrel.2025.114247",
      "doi_url": "https://doi.org/10.1016/j.jconrel.2025.114247",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40976279/",
      "url": "https://h2medizin.org/studien/studie-wang-2025-hierarchische-ros-eliminierende-plattform/",
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        "cardiovascular",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
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      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "40931918",
      "year": 2025,
      "title": "Nanobiokatalysator-gesteuerte raumzeitliche Wasserstoffabgabe induziert dormanz-potenzierte katalytische Tumortherapie.",
      "title_en": "Nanobiocatalyst-Driven Spatiotemporal Hydrogen Delivery Induces Dormancy Potentiated Catalytic Tumor Therapy.",
      "title_de": null,
      "journal": "ACS nano",
      "authors": "Cao et al.",
      "author_search": "cao cao",
      "doi": "10.1021/acsnano.5c10754",
      "doi_url": "https://doi.org/10.1021/acsnano.5c10754",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40931918/",
      "url": "https://h2medizin.org/studien/studie-cao-2025-nanobiokatalysator-gesteuerte-raumzeitliche-wasserstoffabgabe/",
      "methods": [
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      "h2category": "preclinical"
    },
    {
      "pmid": "40885754",
      "year": 2025,
      "title": "Pyroptose-responsive Mikrosphären modulieren die entzündliche Mikroumgebung zur Verzögerung der Osteoporose bei weiblichen Mäusen.",
      "title_en": "Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.",
      "title_de": null,
      "journal": "Nature communications",
      "authors": "Lu et al.",
      "author_search": "lu lu",
      "doi": "10.1038/s41467-025-63456-5",
      "doi_url": "https://doi.org/10.1038/s41467-025-63456-5",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40885754/",
      "url": "https://h2medizin.org/studien/studie-lu-2025-pyroptose-responsive-mikrosphaeren-modulieren/",
      "methods": [
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        "immune-system",
        "oxidative-stress"
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    },
    {
      "pmid": "40877145",
      "year": 2025,
      "title": "Immunmodulatorische Effekte der Therapie mit molekularem Wasserstoff bei systemischem Lupus erythematodes mit Perikarditis und Pleuritis: Ein Fallbericht",
      "title_en": "Immunomodulatory Effects of Molecular Hydrogen Therapy in Systemic Lupus Erythematosus With Pericarditis and Pleuritis: A Case Report.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Tu et al.",
      "author_search": "tu tu",
      "doi": "10.21873/invivo.14103",
      "doi_url": "https://doi.org/10.21873/invivo.14103",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40877145/",
      "url": "https://h2medizin.org/studien/studie-tu-2025-immunmodulatorische-effekte-systemischem-lupus/",
      "methods": [
        "drinking-hrw"
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      "indications": [
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        "immune-system",
        "oxidative-stress",
        "fundamentals-safety"
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      "evidence_level": 2,
      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "40874435",
      "year": 2025,
      "title": "Wasserstoff dämpft die Seneszenz von aus Fettgewebe gewonnenen Stammzellen und verstärkt deren myogene Differenzierung durch Modulation des PRDX6/SIRT1/PGC-1α-Signalwegs.",
      "title_en": "Hydrogen attenuates the senescence of adipose-derived stem cells and enhances their myogenic differentiation via modulation of the PRDX6/SIRT1/PGC-1α signaling pathway.",
      "title_de": null,
      "journal": "Human & experimental toxicology",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40874435/",
      "url": "https://h2medizin.org/studien/studie-zhang-2025-daempft-seneszenz-aus-fettgewebe/",
      "methods": [
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        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "40864154",
      "year": 2025,
      "title": "Lokale Verabreichung von molekularem Wasserstoff durch fluorierte zeolithische Imidazol-Gerüst-Nanoblätter verstärkt die Krebs-Immuntherapie.",
      "title_en": "Local Delivery of Molecular Hydrogen by Fluorinated Zeolitic Imidazole Framework Nanosheets Boosts Cancer Immunotherapy.",
      "title_de": null,
      "journal": "ACS applied materials & interfaces",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1021/acsami.5c15739",
      "doi_url": "https://doi.org/10.1021/acsami.5c15739",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40864154/",
      "url": "https://h2medizin.org/studien/studie-liu-2025-lokale-verabreichung-fluorierte-zeolithische/",
      "methods": [
        "unspecified"
      ],
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        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "40850177",
      "year": 2025,
      "title": "Integration von QSAR-Modellierung, ADMET-Screening, molekularem Docking und Molekulardynamik-Simulationen zur Identifizierung potenzieller MCF-7-Inhibitoren.",
      "title_en": "Integrating QSAR modeling, ADMET screening, molecular docking, and molecular dynamics simulations to identify potential MCF-7 inhibitors.",
      "title_de": null,
      "journal": "Computers in biology and medicine",
      "authors": "Valizadeh et al.",
      "author_search": "valizadeh valizadeh",
      "doi": "10.1016/j.compbiomed.2025.110972",
      "doi_url": "https://doi.org/10.1016/j.compbiomed.2025.110972",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40850177/",
      "url": "https://h2medizin.org/studien/studie-valizadeh-2025-integration-qsar-modellierung-admet/",
      "methods": [
        "unspecified"
      ],
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      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
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    },
    {
      "pmid": "40845957",
      "year": 2025,
      "title": "Wasserstoff förderte die mitochondriale Autophagie und linderte die CIH-induzierte Seneszenz vaskulärer Endothelzellen durch Regulierung von oxidativem Stress.",
      "title_en": "Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress.",
      "title_de": null,
      "journal": "European journal of pharmacology",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1016/j.ejphar.2025.178078",
      "doi_url": "https://doi.org/10.1016/j.ejphar.2025.178078",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40845957/",
      "url": "https://h2medizin.org/studien/studie-li-2025-foerderte-mitochondriale-autophagie-linderte/",
      "methods": [
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    },
    {
      "pmid": "40833316",
      "year": 2025,
      "title": "Nanobläschen-Wasserstoffwasser im Wet-Wrap-Verband verbessert den Schweregrad bei pädiatrischen Patienten mit atopischer Dermatitis",
      "title_en": "Nano-Bubble Hydrogen Water in Wet-Wrap Dressing Improves the Severity of Pediatric Patients With Atopic Dermatitis.",
      "title_de": null,
      "journal": "Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners",
      "authors": "Wong et al.",
      "author_search": "wong wong",
      "doi": "10.1016/j.pedhc.2025.07.005",
      "doi_url": "https://doi.org/10.1016/j.pedhc.2025.07.005",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40833316/",
      "url": "https://h2medizin.org/studien/studie-wong-2025-nanoblaeschen-wasserstoffwasser-wet-wrap/",
      "methods": [
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        "allergy",
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      "evidence_level": 2,
      "human": true,
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    },
    {
      "pmid": "40733848",
      "year": 2025,
      "title": "3D-Druck kombiniert mit pH-induzierten 4D-gedruckten Gelen aus Eisen(III)-oxidierter Stärke zur kontrollierten Eisenabgabe und verbesserten Eisensupplementierung.",
      "title_en": "3D printing combined with pH-induced 4D printed iron(III)-oxidized starch gels for controlled iron delivery and enhanced iron supplementation.",
      "title_de": null,
      "journal": "Carbohydrate polymers",
      "authors": "Qiu et al.",
      "author_search": "qiu qiu",
      "doi": "10.1016/j.carbpol.2025.123933",
      "doi_url": "https://doi.org/10.1016/j.carbpol.2025.123933",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40733848/",
      "url": "https://h2medizin.org/studien/studie-qiu-2025-druck-kombiniert-induzierten-gedruckten/",
      "methods": [
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        "oxidative-stress",
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      "human": false,
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    },
    {
      "pmid": "40694834",
      "year": 2025,
      "title": "Konsum von wasserstoffreichem Wasser gegen akute und residuale Ermüdung nach simulierten Fußballspielen: Protokoll für eine randomisierte, doppelblinde, placebokontrollierte Parallelstudie",
      "title_en": "Hydrogen-Rich Water Consumption for Acute and Residual Fatigue After Simulated Football Matches: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Parallel Trial.",
      "title_de": null,
      "journal": "JMIR research protocols",
      "authors": "Hruby et al.",
      "author_search": "hruby hruby",
      "doi": "10.2196/69744",
      "doi_url": "https://doi.org/10.2196/69744",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40694834/",
      "url": "https://h2medizin.org/studien/studie-hruby-2025-konsum-wasserstoffreichem-gegen-akute/",
      "methods": [
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        "oxidative-stress"
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      "evidence_level": 2,
      "human": true,
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    },
    {
      "pmid": "40621736",
      "year": 2025,
      "title": "Magnesiumhydrid-induzierte Wasserstofftherapie zur verstärkten sonodynamischen Therapie.",
      "title_en": "Magnesium hydride-induced hydrogen therapy for enhanced sonodynamic therapy.",
      "title_de": null,
      "journal": "Materials horizons",
      "authors": "Huang et al.",
      "author_search": "huang huang",
      "doi": "10.1039/d5mh00585j",
      "doi_url": "https://doi.org/10.1039/d5mh00585j",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40621736/",
      "url": "https://h2medizin.org/studien/studie-huang-2025-magnesiumhydrid-induzierte-wasserstofftherapie-zur/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "40590161",
      "year": 2025,
      "title": "Vorhersage des therapeutischen Ansprechens auf molekularen Wasserstoff bei Autoimmunerkrankungen mittels Immunphänotypisierung",
      "title_en": "Predicting Therapeutic Response to Molecular Hydrogen in Autoimmune Diseases via Immunophenotyping.",
      "title_de": null,
      "journal": "APMIS : acta pathologica, microbiologica, et immunologica Scandinavica",
      "authors": "Lui et al.",
      "author_search": "lui lui",
      "doi": "10.1111/apm.70040",
      "doi_url": "https://doi.org/10.1111/apm.70040",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40590161/",
      "url": "https://h2medizin.org/studien/studie-lui-2025-vorhersage-des-therapeutischen-ansprechens/",
      "methods": [
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        "respiratory",
        "joints-rheumatology",
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        "oxidative-stress"
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      "evidence_level": 2,
      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "40579028",
      "year": 2025,
      "title": "Therapie mit molekularem Wasserstoff bei rheumatoider Arthritis: Ein Fallbericht über die Besserung der Methotrexat-induzierten Myelosuppression und Immunmodulation",
      "title_en": "Molecular Hydrogen Therapy in Rheumatoid Arthritis: A Case Report on the Amelioration of Methotrexate-induced Myelosuppression and Immune Modulation.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Tu et al.",
      "author_search": "tu tu",
      "doi": "10.21873/invivo.14014",
      "doi_url": "https://doi.org/10.21873/invivo.14014",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40579028/",
      "url": "https://h2medizin.org/studien/studie-tu-2025-rheumatoider-arthritis-fallbericht-besserung/",
      "methods": [
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        "kidney-dialysis",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
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    },
    {
      "pmid": "40579023",
      "year": 2025,
      "title": "Molekularer Wasserstoff als adjuvante Therapie bei komorbidem Sjögren-Syndrom, SLE und ILD: Ein Fallbericht über Immunmodulation und Reduktion der Ermüdung",
      "title_en": "Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sjögren's Syndrome, SLE, and ILD: A Case Report on Immune Modulation and Fatigue Reduction.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Tsai et al.",
      "author_search": "tsai tsai",
      "doi": "10.21873/invivo.14018",
      "doi_url": "https://doi.org/10.21873/invivo.14018",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40579023/",
      "url": "https://h2medizin.org/studien/studie-tsai-2025-adjuvante-komorbidem-sjoegren-syndrom/",
      "methods": [
        "unspecified"
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      "indications": [
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        "respiratory",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
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      "evidence_level": 2,
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    {
      "pmid": "40295001",
      "year": 2025,
      "title": "Therapie mit molekularem Wasserstoff in Kapselform bei primär biliärer Cholangitis mit erhöhtem IgG4: Ein Fallbericht über die Normalisierung von Immunmarkern",
      "title_en": "Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.21873/invivo.13968",
      "doi_url": "https://doi.org/10.21873/invivo.13968",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40295001/",
      "url": "https://h2medizin.org/studien/studie-lin-2025-kapselform-primaer-biliaerer-cholangitis/",
      "methods": [
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      "indications": [
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        "skin-aging",
        "immune-system",
        "oxidative-stress"
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      "evidence_level": 2,
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    },
    {
      "pmid": "40259480",
      "year": 2025,
      "title": "RNA-Seq enthüllt den Mechanismus der synergistischen Wasserstoff-Chemotherapie auf Basis aktiver Magnesium-Mikromotoren zur Hemmung des Glioblastom-Rezidivs durch Modulation der Tumormikroumgebung.",
      "title_en": "RNA-Seq Reveals the Mechanism of Synergistic Hydrogen-Chemotherapy Based on Active Magnesium Micromotors for Inhibiting Glioblastoma Recurrence by Modulating Tumor Microenvironment.",
      "title_de": null,
      "journal": "Small (Weinheim an der Bergstrasse, Germany)",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1002/smll.202408809",
      "doi_url": "https://doi.org/10.1002/smll.202408809",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40259480/",
      "url": "https://h2medizin.org/studien/studie-zhang-2025-rna-seq-enthuellt-den/",
      "methods": [
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        "immune-system",
        "oxidative-stress"
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      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "40251018",
      "year": 2025,
      "title": "Diätetische Zugabe von Magnesiumhydrid-Nanopartikeln: ein Durchbruch bei der Bekämpfung der durch fettreiche Ernährung induzierten chronischen Nierenerkrankung.",
      "title_en": "Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.",
      "title_de": null,
      "journal": "Medical gas research",
      "authors": "Lu et al.",
      "author_search": "lu lu",
      "doi": "10.4103/mgr.medgasres-d-24-00090",
      "doi_url": "https://doi.org/10.4103/mgr.medgasres-d-24-00090",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40251018/",
      "url": "https://h2medizin.org/studien/studie-lu-2025-diaetetische-zugabe-magnesiumhydrid-nanopartikeln/",
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        "oxidative-stress"
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      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "40238879",
      "year": 2025,
      "title": "Wasserstoff-induzierte Störung der Atemwegsschleimbarriere verstärkt die vernebelte RNA-Abgabe zur Umkehrung der Lungenfibrose.",
      "title_en": "Hydrogen-induced disruption of the airway mucus barrier enhances nebulized RNA delivery to reverse pulmonary fibrosis.",
      "title_de": null,
      "journal": "Science advances",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1126/sciadv.adt2752",
      "doi_url": "https://doi.org/10.1126/sciadv.adt2752",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40238879/",
      "url": "https://h2medizin.org/studien/studie-liu-2025-induzierte-stoerung-atemwegsschleimbarriere-verstaerkt/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "40189120",
      "year": 2025,
      "title": "Ein teilweise abbaubarer Verbundwerkstoff aus metallischem Ti-Zr-Cu-Pd-Sn-Glas und Fe-Mg-Legierung für orthopädische Anwendungen.",
      "title_en": "A partially degradable composite consisting of Ti-Zr-Cu-Pd-Sn metallic glass and Fe-Mg alloy for orthopedic applications.",
      "title_de": null,
      "journal": "Acta biomaterialia",
      "authors": "Du et al.",
      "author_search": "du du",
      "doi": "10.1016/j.actbio.2025.04.011",
      "doi_url": "https://doi.org/10.1016/j.actbio.2025.04.011",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40189120/",
      "url": "https://h2medizin.org/studien/studie-du-2025-teilweise-abbaubarer-verbundwerkstoff-aus/",
      "methods": [
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      "human": false,
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    {
      "pmid": "40077785",
      "year": 2025,
      "title": "Wasserstoff- und Methannachweis in der Atemluft als Reaktion auf zwei verschiedene Ballaststoffarten und dessen Zusammenhang mit der postprandialen Glukosekonzentration bei adipösen Patienten mit Typ-2-Diabetes und normoglykämischen Probanden",
      "title_en": "Hydrogen and Methane Detection in Breath in Response to Two Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Concentration in Obese Patients with Type 2 Diabetes and Normoglycemic Subjects.",
      "title_de": null,
      "journal": "Nutrients",
      "authors": "Misnikova et al.",
      "author_search": "misnikova misnikova",
      "doi": "10.3390/nu17050917",
      "doi_url": "https://doi.org/10.3390/nu17050917",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40077785/",
      "url": "https://h2medizin.org/studien/studie-misnikova-2025-methannachweis-atemluft-reaktion-zwei/",
      "methods": [],
      "indications": [
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        "metabolic"
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      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "40066473",
      "year": 2025,
      "title": "Galvanische bipolare Mikronadel-Pflaster zur Umkehrung von Photoalterungs-Falten.",
      "title_en": "Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles.",
      "title_de": null,
      "journal": "Advanced materials (Deerfield Beach, Fla.)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.1002/adma.202500552",
      "doi_url": "https://doi.org/10.1002/adma.202500552",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40066473/",
      "url": "https://h2medizin.org/studien/studie-lin-2025-galvanische-bipolare-mikronadel-pflaster/",
      "methods": [
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      "indications": [
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        "immune-system",
        "oxidative-stress"
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      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "40010997",
      "year": 2025,
      "title": "Therapie mit molekularem Wasserstoff verstärkt Immunmarker in Treg-, Plasma-, Tr1-Zellen und die KLRG1-Expression auf Tc-Zellen: Ein Fall von akutem Subduralhämatom mit Mittellinienverlagerung und Unkusherniation nach dekompressiver Kraniektomie",
      "title_en": "Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Hsu et al.",
      "author_search": "hsu hsu",
      "doi": "10.21873/invivo.13923",
      "doi_url": "https://doi.org/10.21873/invivo.13923",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40010997/",
      "url": "https://h2medizin.org/studien/studie-hsu-2025-verstaerkt-immunmarker-treg-plasma/",
      "methods": [
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      "indications": [
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        "neurology",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "40010970",
      "year": 2025,
      "title": "Therapie mit molekularem Wasserstoff bei SLE-PAH: Fallbericht über die Modulation von Immunmarkern",
      "title_en": "Molecular Hydrogen Therapy for SLE-PAH: Case Report on Immune Marker Modulation.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Tu et al.",
      "author_search": "tu tu",
      "doi": "10.21873/invivo.13926",
      "doi_url": "https://doi.org/10.21873/invivo.13926",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40010970/",
      "url": "https://h2medizin.org/studien/studie-tu-2025-sle-pah-fallbericht-modulation/",
      "methods": [
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      "indications": [
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        "respiratory",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "40010949",
      "year": 2025,
      "title": "Molekularer Wasserstoff als adjuvante Therapie bei schwerer Lupus-Serositis mit Herzinsuffizienz: Ein Fallbericht über Immunmodulation und Reduktion der Ermüdung",
      "title_en": "Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.21873/invivo.13924",
      "doi_url": "https://doi.org/10.21873/invivo.13924",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/40010949/",
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      "year": 2025,
      "title": "Leistung unmodifizierter mechanischer Beatmungsgeräte mit 2%-Wasserstoffgasgemischen.",
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      "title": "Hämodialyse mit molekularem Wasserstoff (H₂)-angereicherter Dialyselösung könnte die dialysebedingte Ermüdung durch Einfluss auf den Energiestoffwechsel verbessern",
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      "title": "Ternärer Schottky-Übergang zur sonokatalytischen Wasserspaltung in der gas-immuntherapie-vermittelten Krebsbehandlung.",
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      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
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      "title": "Ein H₂/Fluorouracil-freisetzendes Suppositorium mit anhaltender Wirkung für die hocheffiziente und niedertoxische Hydrogeno-Chemotherapie von Dickdarmkrebs.",
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      "title": "Wasserstoffreiche Kochsalzlösung in Kombination mit Vakuumversiegelungsdrainage fördert die Wundheilung durch Veränderung des Biotin-Stoffwechsels",
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      "doi": "10.1111/jcmm.70292",
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      "pmid": "39791170",
      "year": 2025,
      "title": "Schützende Wirkungen der Wasserstoffbehandlung gegen durch hohe Glukose induzierten oxidativen Stress und Apoptose über die Hemmung des AGEs/RAGE/NF-κB-Signalwegs in Hautzellen.",
      "title_en": "Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells.",
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      "title": "Mangan-Galvanikzellen greifen in den Tumorstoffwechsel ein, um die cGAS-STING-Aktivierung für eine bidirektionale synergistische Wasserstoff-Immuntherapie zu verstärken.",
      "title_en": "Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.",
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      "journal": "Advanced materials (Deerfield Beach, Fla.)",
      "authors": "Yang et al.",
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      "pmid": "39740897",
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      "title": "Molekularer Wasserstoff als potenzielle adjunktive Therapie zur Verbesserung der Nierenfunktion und Reduktion der Ermüdung bei einem älteren Patienten mit chronischen Komorbiditäten: Ein Fallbericht",
      "title_en": "Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report.",
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      "title": "Präzise Bewertung der Anti-NMDA-Rezeptor-Enzephalitis: Ein Fallbericht über die Integration von klinischem Verlauf, Immunphänotypisierung und umfassender Symptomatologie bei einem pädiatrischen Patienten mit adjunktiver Wasserstofftherapie",
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      "year": 2025,
      "title": "Vielseitige immunmodulatorische Nanokomplexe zielen auf neutrophile ROS-Entzündung bei akuter Lungenschädigung ab.",
      "title_en": "Multifaceted Immunomodulatory Nanocomplexes Target Neutrophilic-ROS Inflammation in Acute Lung Injury.",
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      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Su et al.",
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      "pmid": "39726077",
      "year": 2025,
      "title": "Hydrolyse von 2D-Nanoblättern kehrt rheumatoide Arthritis durch Entzündungshemmung und Osteogenese um.",
      "title_en": "Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.",
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      "journal": "Advanced materials (Deerfield Beach, Fla.)",
      "authors": "Ji et al.",
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      "doi": "10.1002/adma.202415543",
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      "year": 2025,
      "title": "Wasserstofferzeugender Magnesiumlegierungs-Seed-Strang sensibilisiert solide Tumoren für die Iod-125-Brachytherapie.",
      "title_en": "Hydrogen-Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine-125 Brachytherapy.",
      "title_de": null,
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Hu et al.",
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      "url": "https://h2medizin.org/studien/studie-hu-2025-wasserstofferzeugender-magnesiumlegierungs-seed-strang/",
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      "title": "Lebende Therapeutika für die synergistische photothermische Wasserstoff-Krebsbehandlung durch photosynthetische Bakterien.",
      "title_en": "Living Therapeutics for Synergistic Hydrogen-Photothermal Cancer Treatment by Photosynthetic Bacteria.",
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      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Zhang et al.",
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      "title": "Entwicklung probiotischer Biowasserstoff-Mikrofabriken zur Auslösung von reduktivem Stress zur Verstärkung der Tumorvulnerabilität.",
      "title_en": "Engineering probiotic biohydrogen micro-factories to initiate reductive stress for boosting tumor vulnerability.",
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      "journal": "Biomaterials",
      "authors": "Jiang et al.",
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      "url": "https://h2medizin.org/studien/studie-jiang-2025-entwicklung-probiotischer-biowasserstoff-mikrofabriken/",
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    {
      "pmid": "39190941",
      "year": 2025,
      "title": "Mitochondrialer ‚Geburt-Tod'-Koordinator: Ein intelligenter Wasserstoff-Nanogenerator zur Verstärkung der Bandscheibenregeneration",
      "title_en": "Mitochondrial 'Birth-Death' coordinator: An intelligent hydrogen nanogenerator to enhance intervertebral disc regeneration.",
      "title_de": null,
      "journal": "Biomaterials",
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      "doi": "10.1016/j.biomaterials.2024.122764",
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    {
      "pmid": "38634423",
      "year": 2025,
      "title": "Wirkung von wasserstoffreicher Kochsalzlösung auf Melanopsin nach akutem blaulichtinduziertem Netzhautschaden bei Ratten",
      "title_en": "Effect of hydrogen-rich saline on melanopsin after acute blue light-induced retinal damage in rats",
      "title_de": null,
      "journal": "Photochemistry and Photobiology",
      "authors": "Wang et al.",
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      "doi": "10.1111/php.13952",
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      "url": "https://h2medizin.org/studien/studie-wang-2025-wasserstoffreiche-kochsalzloesung-melanopsin-blaulicht-netzhaut/",
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      "year": 2025,
      "title": "Wasserstoff aktiviert den ACOD1-Itaconat-Signalweg zur Linderung steroidassoziierter Osteonekrose",
      "title_en": "Hydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis",
      "title_de": null,
      "journal": "Biomaterials",
      "authors": "An et al.",
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      "doi": "10.1016/j.biomaterials.2025.123428",
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      "url": "https://h2medizin.org/studien/studie-an-2025-acod1-itaconat-steroid-osteonekrose/",
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      "title": "Molekularer Wasserstoff mildert die durch Cisplatin ausgelöste Nierentoxizität durch Modulation des β-Hydroxybutyrat-Stoffwechsels",
      "title_en": "Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism",
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      "authors": "Tian et al.",
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      "url": "https://h2medizin.org/studien/studie-tian-2025-cisplatin-nierentoxizitaet-beta-hydroxybutyrat/",
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    {
      "pmid": "38256045",
      "year": 2024,
      "title": "Wasserstoffwasser: extra gesund oder Schwindel? — Eine systematische Übersicht",
      "title_en": "Hydrogen Water: Extra Healthy or a Hoax?-A Systematic Review",
      "title_de": null,
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      "authors": "Dhillon et al.",
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    {
      "pmid": "39808170",
      "year": 2024,
      "title": "Neue Möglichkeiten der Prävention und Behandlung kardiovaskulärer Pathologien: Das Potenzial von molekularem Wasserstoff bei der Reduzierung von oxidativem Stress",
      "title_en": "New possibilities of the prevention and treatment of cardiovascular pathologies. the potential of molecular hydrogen in the reduction of oxidative stress and its consequences.",
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      "journal": "Physiological research",
      "authors": "Slezák et al.",
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      "doi": "10.33549/physiolres.935491",
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    {
      "pmid": "39487838",
      "year": 2024,
      "title": "Perspektivische gezielte Diagnose und Therapie der mitochondrialen Bioenergetik bei verschiedenen Diagnosen",
      "title_en": "Perspective targeted diagnosis and therapy of mitochondrial bioenergetics across different diagnoses.",
      "title_de": null,
      "journal": "Bratislavske lekarske listy",
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      "year": 2024,
      "title": "Die Landschaft der auf intelligenten Biomaterialien basierenden Wasserstofftherapie",
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      "title": "Die schützende Rolle von molekularem Wasserstoff bei Ischämie-/Reperfusionsschäden",
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      "title": "Idiopathischer plötzlicher sensorineuraler Hörverlust: Eine Übersichtsarbeit mit Fokus auf den Beitrag vaskulärer Pathologien",
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      "title": "Potenzielle Rolle der Therapie mit molekularem Wasserstoff bei oxidativem Stress und Redox-Signalübertragung bei chronischer Nierenerkrankung",
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      "title": "Untersuchung von Ansätzen zur Beurteilung der Pulpavitalität: Ein Scoping Review nichttraditioneller Methoden",
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      "title": "Die Rolle von Wasserstoff bei der Prävention und Behandlung der koronaren atherosklerotischen Herzkrankheit",
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      "title": "Katalytische Innovationen: Verbesserung von Abwasserbehandlungs- und Wasserstofferzeugungstechnologien.",
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      "title": "Die Wirkung des Konsums von wasserstoffreichem Wasser auf prämenstruelle Symptome und Lebensqualität: eine randomisierte kontrollierte Studie",
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      "title": "Wasserstoffreiches Gas verbessert die Sprint-Intervall-Leistung: Metabolomische Einblicke in die zugrunde liegenden Mechanismen",
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      "title": "H2-Inhalationstherapie bei Patienten mit moderatem COVID-19 (H2COVID): eine prospektive Phase-I-Studie mit ansteigender Dosis",
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      "title": "Einsatz oraler molekularer Wasserstoff-Präparate zur Bekämpfung von Mikroinflammation beim Menschen: eine Pilot-Beobachtungsstudie",
      "title_en": "Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study.",
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    {
      "pmid": "39477420",
      "year": 2024,
      "title": "Molekulare Wasserstofftherapie bei aneurysmatischer SAB mit RA und neu diagnostiziertem SLE, kompliziert durch akuten ischämischen Infarkt: Ein Fallbericht über verbesserte Immunmarker einschließlich Tr1-Zellen, Breg-Zellen und TIM3-Expression auf Tc-Zellen.",
      "title_en": "Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.21873/invivo.13799",
      "doi_url": "https://doi.org/10.21873/invivo.13799",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39477420/",
      "url": "https://h2medizin.org/studien/studie-chen-2024-molekulare-wasserstofftherapie-aneurysmatischer-sab/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "skin-aging",
        "joints-rheumatology",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39477378",
      "year": 2024,
      "title": "Molekulare Wasserstofftherapie beim Sjögren-Syndrom mit pulmonaler arterieller Hypertonie und Rechtsherzinsuffizienz: Ein Fallbericht über verbesserte Immunmarker einschließlich Treg, B-Zellen und Plasmazellen.",
      "title_en": "Molecular Hydrogen Therapy in Sjögren's Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.21873/invivo.13797",
      "doi_url": "https://doi.org/10.21873/invivo.13797",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39477378/",
      "url": "https://h2medizin.org/studien/studie-lin-2024-molekulare-wasserstofftherapie-beim-sjoegren/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cardiovascular",
        "respiratory",
        "skin-aging",
        "immune-system"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39400361",
      "year": 2024,
      "title": "Modulation der elektronischen Struktur von MnNi₂S₃-Nanoelektroden zur Aktivierung der Pyroptose für die elektrokatalytische Wasserstoff-Immuntherapie.",
      "title_en": "Modulating the Electronic Structure of MnNi2S3 Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen-Immunotherapy.",
      "title_de": null,
      "journal": "Advanced materials (Deerfield Beach, Fla.)",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1002/adma.202412925",
      "doi_url": "https://doi.org/10.1002/adma.202412925",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39400361/",
      "url": "https://h2medizin.org/studien/studie-li-2024-modulation-elektronischen-struktur-mnni2s3/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "liver",
        "cancer",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39271809",
      "year": 2024,
      "title": "Die Wirkung von Wasserstoffgas auf die Reaktion auf oxidativen Stress im Fettgewebe.",
      "title_en": "The effect of hydrogen gas on the oxidative stress response in adipose tissue.",
      "title_de": null,
      "journal": "Scientific reports",
      "authors": "Tumurbaatar et al.",
      "author_search": "tumurbaatar tumurbaatar",
      "doi": "10.1038/s41598-024-72626-2",
      "doi_url": "https://doi.org/10.1038/s41598-024-72626-2",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39271809/",
      "url": "https://h2medizin.org/studien/studie-tumurbaatar-2024-wasserstoffgas-reaktion-oxidativen-stress/",
      "methods": [
        "inhalation"
      ],
      "indications": [
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        "cardiovascular",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39216558",
      "year": 2024,
      "title": "Wasserstoff reguliert die Pyroptose über den NLRP3-GSDMD-Signalweg zur Verbesserung der durch Endotrachealtubus-Cuff-Kompression induzierten oxidativen Stressschädigung der Atemwegsschleimhaut.",
      "title_en": "Hydrogen regulated pyroptosis through NLRP3-GSDMD pathway to improve airway mucosal oxidative stress injury induced by endotracheal tube cuff compression.",
      "title_de": null,
      "journal": "Free radical biology & medicine",
      "authors": "Mu et al.",
      "author_search": "mu mu",
      "doi": "10.1016/j.freeradbiomed.2024.08.035",
      "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2024.08.035",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39216558/",
      "url": "https://h2medizin.org/studien/studie-mu-2024-reguliert-pyroptose-den-nlrp3/",
      "methods": [
        "inhalation",
        "saline-iv"
      ],
      "indications": [
        "respiratory",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39173802",
      "year": 2024,
      "title": "Vielschichtige Untersuchung von Acylthioharnstoff-Verbindungen: In-vitro-Zytotoxizität, DFT-Berechnungen, molekulares Docking und Dynamiksimulationsstudien.",
      "title_en": "Multifaceted exploration of acylthiourea compounds: In vitro cytotoxicity, DFT calculations, molecular docking and dynamics simulation studies.",
      "title_de": null,
      "journal": "International journal of biological macromolecules",
      "authors": "Haribabu et al.",
      "author_search": "haribabu haribabu",
      "doi": "10.1016/j.ijbiomac.2024.134870",
      "doi_url": "https://doi.org/10.1016/j.ijbiomac.2024.134870",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39173802/",
      "url": "https://h2medizin.org/studien/studie-haribabu-2024-vielschichtige-untersuchung-acylthioharnstoff-verbindungen/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39147072",
      "year": 2024,
      "title": "Wasserstoffreiches Wasser lindert die Atemwegsentzündung bei Asthma durch Modulation des Tryptophan-Stoffwechsels und Aktivierung des Aryl-Hydrocarbon-Rezeptors über die Regulation der Darmmikrobiota.",
      "title_en": "Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation.",
      "title_de": null,
      "journal": "Free radical biology & medicine",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1016/j.freeradbiomed.2024.08.009",
      "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2024.08.009",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39147072/",
      "url": "https://h2medizin.org/studien/studie-li-2024-lindert-atemwegsentzuendung-asthma-modulation/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "respiratory",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "39116782",
      "year": 2024,
      "title": "Eine neuartige Intervention mit molekularem Wasserstoff bei der Dysbalance des Darmmikrobioms bei Opioidabhängigkeit: Experimentelle und Humanstudien.",
      "title_en": "A novel intervention of molecular hydrogen on the unbalance of the gut microbiome in opioid addiction: Experimental and human studies.",
      "title_de": null,
      "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
      "authors": "Xie et al.",
      "author_search": "xie xie",
      "doi": "10.1016/j.biopha.2024.117273",
      "doi_url": "https://doi.org/10.1016/j.biopha.2024.117273",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39116782/",
      "url": "https://h2medizin.org/studien/studie-xie-2024-neuartige-intervention-dysbalance-des/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "metabolic",
        "neurology"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "39073335",
      "year": 2024,
      "title": "Hirntherapie mit „intelligenter Medizin“ verwirklichen: Mechanismus und Fallbericht zur Inhalation von molekularem Wasserstoff bei Parkinson-Krankheit.",
      "title_en": "Realizing brain therapy with \"smart medicine\": mechanism and case report of molecular hydrogen inhalation for Parkinson's disease.",
      "title_de": null,
      "journal": "Medical gas research",
      "authors": "Ichikawa et al.",
      "author_search": "ichikawa ichikawa",
      "doi": "10.4103/2045-9912.385949",
      "doi_url": "https://doi.org/10.4103/2045-9912.385949",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/39073335/",
      "url": "https://h2medizin.org/studien/studie-ichikawa-2024-hirntherapie-intelligenter-medizin-verwirklichen/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38945250",
      "year": 2024,
      "title": "d-Aspartat, eine für die menschliche Gesundheit wichtige Aminosäure, unterstützt die anaerobe Atmung bei mehreren Campylobacter-Arten.",
      "title_en": "d-aspartate, an amino-acid important for human health, supports anaerobic respiration in several Campylobacter species.",
      "title_de": null,
      "journal": "Research in microbiology",
      "authors": "Benoit et al.",
      "author_search": "benoit benoit",
      "doi": "10.1016/j.resmic.2024.104219",
      "doi_url": "https://doi.org/10.1016/j.resmic.2024.104219",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38945250/",
      "url": "https://h2medizin.org/studien/studie-benoit-2024-aspartat-menschliche-gesundheit-wichtige/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "sports-exercise",
        "neurology"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38934271",
      "year": 2024,
      "title": "Poly(ionische Flüssigkeit)-geflocktes Chlorella mit bakteriziden und antioxidativen Hydrogel als biologische Wasserstofftherapie für diabetische Wundauflagen.",
      "title_en": "Poly(ionic liquid)-Flocculated Chlorella Loading Bactericidal and Antioxidant Hydrogel as a Biological Hydrogen Therapy for Diabetic Wound Dressing.",
      "title_de": null,
      "journal": "ACS applied materials & interfaces",
      "authors": "Xu et al.",
      "author_search": "xu xu",
      "doi": "10.1021/acsami.4c07104",
      "doi_url": "https://doi.org/10.1021/acsami.4c07104",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38934271/",
      "url": "https://h2medizin.org/studien/studie-xu-2024-poly-ionische-fluessigkeit-geflocktes/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38895823",
      "year": 2024,
      "title": "Mit Wasserstoff behandelte CoCrMo-Legierung: Ein neuartiger Ansatz zur Verbesserung der Biokompatibilität und Abschwächung von Entzündungen bei orthopädischen Implantaten.",
      "title_en": "Hydrogen-treated CoCrMo alloy: a novel approach to enhance biocompatibility and mitigate inflammation in orthopedic implants.",
      "title_de": null,
      "journal": "Journal of materials chemistry. B",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.1039/d4tb00725e",
      "doi_url": "https://doi.org/10.1039/d4tb00725e",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38895823/",
      "url": "https://h2medizin.org/studien/studie-lin-2024-behandelte-cocrmo-legierung-neuartiger/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38863026",
      "year": 2024,
      "title": "Frühe Inhalation eines Wasserstoff-Sauerstoff-Gasgemischs bei Patienten mit aneurysmatischer Subarachnoidalblutung (HOMA): Studienprotokoll für eine randomisierte kontrollierte Studie.",
      "title_en": "Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial.",
      "title_de": null,
      "journal": "Trials",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.1186/s13063-024-08231-5",
      "doi_url": "https://doi.org/10.1186/s13063-024-08231-5",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38863026/",
      "url": "https://h2medizin.org/studien/studie-lin-2024-fruehe-inhalation-sauerstoff-gasgemischs/",
      "methods": [
        "inhalation",
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "skin-aging",
        "fundamentals-safety"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38855154",
      "year": 2024,
      "title": "Wasserstoffreiches Wasser lindert Verstopfung durch Abschwächung des oxidativen Stresses über den Sirtuin1/Nuclear-Factor-Erythroid-2-related-Factor-2/Häm-Oxygenase-1-Signalweg.",
      "title_en": "Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.",
      "title_de": null,
      "journal": "World journal of gastroenterology",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.3748/wjg.v30.i20.2709",
      "doi_url": "https://doi.org/10.3748/wjg.v30.i20.2709",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38855154/",
      "url": "https://h2medizin.org/studien/studie-chen-2024-lindert-verstopfung-abschwaechung-des/",
      "methods": [
        "saline-iv",
        "drinking-hrw"
      ],
      "indications": [
        "neurology",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38795705",
      "year": 2024,
      "title": "Darmbakterien wandeln Glucocorticoide in Gegenwart von Wasserstoffgas in Gestagene um.",
      "title_en": "Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.",
      "title_de": null,
      "journal": "Cell",
      "authors": "McCurry et al.",
      "author_search": "mccurry mc curry",
      "doi": "10.1016/j.cell.2024.05.005",
      "doi_url": "https://doi.org/10.1016/j.cell.2024.05.005",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38795705/",
      "url": "https://h2medizin.org/studien/studie-mccurry-2024-darmbakterien-wandeln-glucocorticoide-gegenwart/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "neurology",
        "pregnancy"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38757665",
      "year": 2024,
      "title": "Die Wasserstofftherapie kehrt die Phänotypen krebsassoziierter Fibroblasten um und remodelliert die Stroma-Mikroumgebung, um eine systemische Antitumor-Immunität zu stimulieren.",
      "title_en": "Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.",
      "title_de": null,
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Meng et al.",
      "author_search": "meng meng",
      "doi": "10.1002/advs.202401269",
      "doi_url": "https://doi.org/10.1002/advs.202401269",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38757665/",
      "url": "https://h2medizin.org/studien/studie-meng-2024-wasserstofftherapie-kehrt-phaenotypen-krebsassoziierter/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38688598",
      "year": 2024,
      "title": "Molekularer Wasserstoff als vielversprechende Therapie könnte mit erhöhten ruhenden Treg-Zellen oder verminderten Fas+-T-Zell-Subpopulationen bei einem IgG4-PF-ILD-Patienten zusammenhängen: Ein Fallbericht.",
      "title_en": "Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report.",
      "title_de": null,
      "journal": "In vivo (Athens, Greece)",
      "authors": "Lui et al.",
      "author_search": "lui lui",
      "doi": "10.21873/invivo.13600",
      "doi_url": "https://doi.org/10.21873/invivo.13600",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38688598/",
      "url": "https://h2medizin.org/studien/studie-lui-2024-vielversprechende-koennte-erhoehten-ruhenden/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "respiratory",
        "skin-aging",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": true,
      "h2category": "therapy"
    },
    {
      "pmid": "38679666",
      "year": 2024,
      "title": "Die kombinierte Anwendung von wasserstoffreichem Wasser und enzymatisch verdautem essbarem Vogelnest verbessert die durch PMA/LPS beeinträchtigte Wundheilung in humanen entzündlichen Zahnfleischgewebe-Äquivalenten.",
      "title_en": "Combined use of hydrogen-rich water and enzyme-digested edible bird's nest improves PMA/LPS-impaired wound healing in human inflammatory gingival tissue equivalents.",
      "title_de": null,
      "journal": "Human cell",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1007/s13577-024-01065-y",
      "doi_url": "https://doi.org/10.1007/s13577-024-01065-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38679666/",
      "url": "https://h2medizin.org/studien/studie-wang-2024-kombinierte-anwendung-wasserstoffreichem-enzymatisch/",
      "methods": [
        "drinking-hrw"
      ],
      "indications": [
        "skin-aging",
        "immune-system",
        "oral-health",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38666450",
      "year": 2024,
      "title": "Endogenes Melanin und wasserstoffbasierte spezifisch aktivierte theranostische Nanoagenzien: Ein neuartiges Multi-Behandlungsparadigma für rheumatoide Arthritis",
      "title_en": "Endogenous Melanin and Hydrogen-Based Specific Activated Theranostics Nanoagents: A Novel Multi-Treatment Paradigm for Rheumatoid Arthritis.",
      "title_de": null,
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1002/advs.202401046",
      "doi_url": "https://doi.org/10.1002/advs.202401046",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38666450/",
      "url": "https://h2medizin.org/studien/studie-chen-2024-endogenes-melanin-wasserstoffbasierte-spezifisch/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "skin-aging",
        "joints-rheumatology",
        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "38642971",
      "year": 2024,
      "title": "Das synergistische Potenzial von Wasserstoffinhalation und hyperbarer Sauerstofftherapie",
      "title_en": "The synergistic potential of hydrogen inhalation and hyperbaric oxygen therapy.",
      "title_de": null,
      "journal": "Journal of vascular surgery",
      "authors": "James et al.",
      "author_search": "james james",
      "doi": "10.1016/j.jvs.2023.11.067",
      "doi_url": "https://doi.org/10.1016/j.jvs.2023.11.067",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/38642971/",
      "url": "https://h2medizin.org/studien/studie-james-2024-synergistische-potenzial-wasserstoffinhalation-hyperbarer/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "38637698",
      "year": 2024,
      "title": "Wasserstoffinhalationstherapie bei Entzündungen und Augenerkrankungen: Eine Übersichtsarbeit der Literatur",
      "title_en": "Hydrogen inhalation therapy for inflammation and eye diseases: a review of the literature.",
      "title_de": null,
      "journal": "Eye (London, England)",
      "authors": "Takefuji",
      "author_search": "takefuji takefuji",
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      "title": "Die Entkopplung der gegenseitigen Förderung von Entzündung und oxidativem Stress mildert den kognitiven Abbau und depressionsähnliches Verhalten bei rmTBI-Mäusen durch Förderung der Myelinerneuerung und des Neuronenüberlebens",
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      "title": "Der Nutzen von Wasserstoffgas als adjuvante Therapie bei chronisch obstruktiver Lungenerkrankung.",
      "title_en": "The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease.",
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      "title": "Ladungsneutralisierung und β-Eliminierungs-Spaltungsmechanismus der L-Rhamnose-α-1,4-D-Glucuronat-Lyase der Familie 42, aufgeklärt mittels Neutronenkristallographie",
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      "title": "Erfolgreiche Behandlung von Ulzera und Hautläsionen beim Morbus Behçet mit Wasserstoffwasser.",
      "title_en": "Successful treatment of Behçet's disease ulcers and skin lesions with hydrogen water.",
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      "title": "Erfolgreiche Behandlung der myalgischen Enzephalomyelitis/des chronischen Erschöpfungssyndroms mit Wasserstoffgas: Vier Fallberichte.",
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      "title_en": "High-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics",
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      "year": 2024,
      "title": "Natürliches Wasserstoffgas und maßgeschneiderte Mikroalgen verhindern akuten Lungenschaden bei Sepsis",
      "title_en": "Natural hydrogen gas and engineered microalgae prevent acute lung injury in sepsis",
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      "pmid": "36708550",
      "year": 2023,
      "title": "Ein systematischer Review der molekularen Wasserstofftherapie in der Krebsbehandlung",
      "title_en": "A Systematic Review of Molecular Hydrogen Therapy in Cancer Management.",
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      "title": "Molekularer Wasserstoff: Von molekularen Effekten bis zum Stammzell-Management und zur Geweberegeneration",
      "title_en": "Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration",
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      "title": "Molekularer Wasserstoff: Aufkommende Behandlung für das Schlaganfall-Management",
      "title_en": "Molecular Hydrogen: Emerging Treatment for Stroke Management",
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    {
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      "year": 2023,
      "title": "Molekulare Wasserstofftherapie – Eine Übersichtsarbeit zu klinischen Studien und Ergebnissen",
      "title_en": "Molecular Hydrogen Therapy-A Review on Clinical Studies and Outcomes.",
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      "journal": "Molecules (Basel, Switzerland)",
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      "title": "Die Rolle der Wasserstofftherapie im Management der Alzheimer-Krankheit: Einblicke in Mechanismen, Verabreichungswege und zukünftige Herausforderungen",
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      "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
      "authors": "He et al.",
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      "year": 2023,
      "title": "Die Wasserstofftherapie als potenzielle therapeutische Intervention bei Herzerkrankungen: Von der bisherigen Evidenz zur zukünftigen Anwendung",
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      "authors": "Saengsin et al.",
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      "title": "Neuartige therapeutische Ansätze auf Basis der pathologischen Rolle der Darmdysbiose für den Zusammenhang zwischen nichtalkoholischer Fettlebererkrankung und Insulinresistenz",
      "title_en": "Novel therapeutic approaches based on the pathological role of gut dysbiosis on the link between nonalcoholic fatty liver disease and insulin resistance.",
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    {
      "pmid": "36571374",
      "year": 2023,
      "title": "Die übersehenen Vorteile wasserstoffproduzierender Bakterien",
      "title_en": "The overlooked benefits of hydrogen-producing bacteria.",
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      "title": "Molekularer Wasserstoff: Ein aufkommendes therapeutisches medizinisches Gas für Hirnerkrankungen",
      "title_en": "Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders.",
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      "title": "Molekularer Wasserstoff verbessert den Funktionszustand roter Blutkörperchen in der frühen postoperativen Phase: eine randomisierte klinische Studie",
      "title_en": "Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study",
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      "authors": "Deryugina et al.",
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      "year": 2023,
      "title": "Wasserstoffgas-Behandlung verbessert postoperatives Delir und kognitive Dysfunktion bei älteren nicht-kardialen Patienten",
      "title_en": "Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients",
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      "authors": "Lin et al.",
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      "year": 2023,
      "title": "Effekt der akuten Aufnahme von wasserstoffreichem Wasser auf den Augeninnendruck bei gesunden Probanden",
      "title_en": "EFFECT OF ACUTE HYDROGEN-RICH WATER INTAKE ON INTRAOCULAR PRESSURE IN HEALTHY SUBJECTS",
      "title_de": null,
      "journal": "Ceska a slovenska oftalmologie",
      "authors": "Najmanová et al.",
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      "pmid": "38156844",
      "year": 2023,
      "title": "Der Hemmmechanismus des duktalen Pankreasadenokarzinoms über LXR-Rezeptoren: Ein vielschichtiger Ansatz unter Integration von molekularem Docking, Moleküldynamik und Post-MD-Intermolekular-Kontaktanalyse",
      "title_en": "The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis.",
      "title_de": null,
      "journal": "Asian Pacific journal of cancer prevention : APJCP",
      "authors": "Agar et al.",
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    {
      "pmid": "37797471",
      "year": 2023,
      "title": "Die Wirkung von wasserstoffreichem Wasser auf das letrozolinduzierte polyzystische Ovarialsyndrom bei Ratten",
      "title_en": "The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats.",
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      "doi": "10.1016/j.rbmo.2023.103332",
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      "year": 2023,
      "title": "Wasserstoffreiches Wasser erhöht die fäkalen Propionsäurespiegel bei übergewichtigen Erwachsenen.",
      "title_en": "Hydrogen-rich water upregulates fecal propionic acid levels in overweight adults.",
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      "authors": "Korovljev et al.",
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      "year": 2023,
      "title": "Veränderungen im negativen Logarithmus des endexspiratorischen Wasserstoffpartialdrucks weisen auf die Variation des Elektrodenpotenzials bei gesunden japanischen Probanden hin.",
      "title_en": "Changes in the negative logarithm of end-tidal hydrogen partial pressure indicate the variation of electrode potential in healthy Japanese subjects.",
      "title_de": null,
      "journal": "Scientific reports",
      "authors": "Kiyama et al.",
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      "doi": "10.1038/s41598-023-42651-8",
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      "url": "https://h2medizin.org/studien/studie-kiyama-2023-veraenderungen-negativen-logarithmus-des/",
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      "pmid": "37587791",
      "year": 2023,
      "title": "Ultraschallgetriebene piezoelektrokatalytische Immunaktivierung tiefer Tumoren",
      "title_en": "Ultrasound-Driven Piezoelectrocatalytic Immunoactivation of Deep Tumor.",
      "title_de": null,
      "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
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      "doi": "10.1002/advs.202303016",
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      "year": 2023,
      "title": "Abschwächung pulmonaler Schäden bei gealterten, lipopolysaccharidinduzierten Entzündungsmäusen durch kontinuierliche Inhalation von 2 % Wasserstoffgas: Eine potenzielle therapeutische Strategie für geriatrische Entzündung und Überleben",
      "title_en": "Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival.",
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      "pmid": "37569850",
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      "title": "Die Wirkung der adjuvanten Therapie mit molekularem Wasserstoff auf die endogenen Coenzym-Q10-Spiegel und die mitochondriale Bioenergetik der Thrombozyten bei Patienten mit nichtalkoholischer Fettlebererkrankung.",
      "title_en": "The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease.",
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      "title": "Wasserstoffreiche Kochsalzlösung reguliert die Aktivierung des NLRP3-Inflammasoms in einem Rattenmodell der sepsisassoziierten Enzephalopathie",
      "title_en": "Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model.",
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    {
      "pmid": "37397014",
      "year": 2023,
      "title": "Die Behandlung mit wasserstoffreichem Wasser zielt auf RT1-Db1 und RT1-Bb ab, um vorzeitiges Ovarialversagen bei Ratten zu lindern",
      "title_en": "Hydrogen-rich water treatment targets RT1-Db1 and RT1-Bb to alleviate premature ovarian failure in rats.",
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      "journal": "PeerJ",
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      "url": "https://h2medizin.org/studien/studie-meng-2023-wasserstoffreichem-zielt-rt1-db1/",
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    {
      "pmid": "37322527",
      "year": 2023,
      "title": "Durch Fermentation im menschlichen Darm erzeugter H₂ beeinflusst den Stoffwechsel und die kompetitive Fitness von Darmbutyratproduzenten.",
      "title_en": "H2 generated by fermentation in the human gut microbiome influences metabolism and competitive fitness of gut butyrate producers.",
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      "authors": "Campbell et al.",
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      "url": "https://h2medizin.org/studien/studie-campbell-2023-fermentation-menschlichen-darm-erzeugter/",
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      "pmid": "37196556",
      "year": 2023,
      "title": "Wasserstoffgas lindert akute alkoholische Leberschäden über entzündungshemmende und antioxidative Wirkungen sowie die Regulation der Darmmikrobiota",
      "title_en": "Hydrogen gas ameliorates acute alcoholic liver injury via anti-inflammatory and antioxidant effects and regulation of intestinal microbiota.",
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      "doi": "10.1016/j.intimp.2023.110252",
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      "url": "https://h2medizin.org/studien/studie-liu-2023-wasserstoffgas-lindert-akute-alkoholische/",
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    {
      "pmid": "37077121",
      "year": 2023,
      "title": "Trend der Forschung zur medizinischen Anwendung von molekularem Wasserstoff: Eine bibliometrische Analyse",
      "title_en": "Trend of research on the medical use of molecular hydrogen: a bibliometric analysis.",
      "title_de": null,
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      "authors": "Li et al.",
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    {
      "pmid": "36912868",
      "year": 2023,
      "title": "Mit anorganischen Nanoschichten abgeschirmte Probiotika: Ein selbstanpassendes orales Verabreichungssystem zur Behandlung von Darmerkrankungen",
      "title_en": "Inorganic Nanosheet-Shielded Probiotics: A Self-Adaptable Oral Delivery System for Intestinal Disease Treatment.",
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      "journal": "Nano letters",
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    {
      "pmid": "36807963",
      "year": 2023,
      "title": "Intermittierende umweltbedingte Exposition gegenüber Wasserstoff verhindert Hautphotoalterung durch Reduktion von oxidativem Stress",
      "title_en": "Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress.",
      "title_de": null,
      "journal": "Geriatrics & gerontology international",
      "authors": "Kiyoi et al.",
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      "pmid": "36778204",
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      "title": "pH-responsive Abgabe von H₂ durch Ammoniak-Boran-beladenes hohles Polydopamin zur Therapie der Bandscheibendegeneration",
      "title_en": "pH-Responsive Delivery of H2 through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy.",
      "title_de": null,
      "journal": "Oxidative medicine and cellular longevity",
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      "pmid": "36768345",
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      "title": "Biologische Aktivität neuartiger Organozinnverbindungen mit einer Schiff-Base, die ein antioxidatives Fragment enthält",
      "title_en": "Biological Activity of Novel Organotin Compounds with a Schiff Base Containing an Antioxidant Fragment.",
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      "journal": "International journal of molecular sciences",
      "authors": "Antonenko et al.",
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    {
      "pmid": "36596238",
      "year": 2023,
      "title": "PdO-Nanopartikel-eingebettete Kohlenstoffnanoröhren-Garne für tragbare Wasserstoffgas-Sensorplattformen mit schnellen und empfindlichen Reaktionen",
      "title_en": "PdO-Nanoparticle-Embedded Carbon Nanotube Yarns for Wearable Hydrogen Gas Sensing Platforms with Fast and Sensitive Responses.",
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      "authors": "Son et al.",
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      "doi": "10.1021/acssensors.2c01743",
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      "pmid": "36571379",
      "year": 2023,
      "title": "H₂-induzierte vorübergehende Hochregulierung von Phospholipiden bei gleichzeitiger Unterdrückung des Energiestoffwechsels",
      "title_en": "H2-induced transient upregulation of phospholipids with suppression of energy metabolism.",
      "title_de": null,
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      "authors": "Iketani et al.",
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      "pmid": "36546774",
      "year": 2023,
      "title": "Zweidimensionale Mg₂Si-Nanoschichten ermöglichen eine anhaltende Wasserstofferzeugung zur verbesserten Reparatur und Regeneration tief verbrannter Haut",
      "title_en": "Two-Dimensional Mg2 Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin.",
      "title_de": null,
      "journal": "Advanced healthcare materials",
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      "year": 2023,
      "title": "Wasserstoffproduzierender Photokatalysator in Sonnenschutzmitteln für Sportler zur Prävention und Heilung von Muskel-Nerven-Haut-Verletzungen",
      "title_en": "Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries.",
      "title_de": null,
      "journal": "Current topics in medicinal chemistry",
      "authors": "Sahoo",
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      "year": 2023,
      "title": "Auswirkungen einer Intervention mit molekularem Wasserstoff auf das Darmmikrobiom bei Methamphetaminkonsumenten mit psychischer Störung.",
      "title_en": "Effects of molecular hydrogen intervention on the gut microbiome in methamphetamine abusers with mental disorder.",
      "title_de": null,
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      "pmid": "36460289",
      "year": 2023,
      "title": "Langzeit-In-vivo-Beobachtungen zeigen Biokompatibilität und Leistung von ZX00-Magnesiumschrauben, deren Oberfläche durch plasmaelektrolytische Oxidation modifiziert wurde, bei Göttinger Miniaturschweinen",
      "title_en": "Long-term in vivo observations show biocompatibility and performance of ZX00 magnesium screws surface-modified by plasma-electrolytic oxidation in Göttingen miniature pigs.",
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      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "36330842",
      "year": 2023,
      "title": "Wasserstoff unterdrückt oxidativen Stress durch Hemmung des p38-MAPK-Signalwegs bei Präeklampsie",
      "title_en": "Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia.",
      "title_de": null,
      "journal": "Advances in clinical and experimental medicine : official organ Wroclaw Medical University",
      "authors": "Guo et al.",
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      "doi": "10.17219/acem/154623",
      "doi_url": "https://doi.org/10.17219/acem/154623",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36330842/",
      "url": "https://h2medizin.org/studien/studie-guo-2023-unterdrueckt-oxidativen-stress-hemmung/",
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        "pregnancy",
        "oxidative-stress"
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      "human": false,
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    },
    {
      "pmid": "36307299",
      "year": 2023,
      "title": "Eine potenzielle klinische Anwendung von wasserstoffreicher Kochsalzlösung in der postoperativen Versorgung",
      "title_en": "A potential clinical application of hydrogen-rich saline in postoperative care.",
      "title_de": null,
      "journal": "Journal of pediatric surgery",
      "authors": "Wong et al.",
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      "doi": "10.1016/j.jpedsurg.2022.09.041",
      "doi_url": "https://doi.org/10.1016/j.jpedsurg.2022.09.041",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36307299/",
      "url": "https://h2medizin.org/studien/studie-wong-2023-potenzielle-klinische-anwendung-wasserstoffreicher/",
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      "human": false,
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      "h2category": "review"
    },
    {
      "pmid": "36165523",
      "year": 2023,
      "title": "Molekularer Wasserstoff fördert die myogene Differenzierung von aus Fettgewebe stammenden Stammzellen über die Regulation der Mitochondrien",
      "title_en": "Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation via Regulation of Mitochondria.",
      "title_de": null,
      "journal": "Current stem cell research & therapy",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.2174/1574888x17666220926115240",
      "doi_url": "https://doi.org/10.2174/1574888x17666220926115240",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36165523/",
      "url": "https://h2medizin.org/studien/studie-yang-2023-foerdert-myogene-differenzierung-aus/",
      "methods": [
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        "skin-aging",
        "immune-system",
        "oxidative-stress"
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      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "35962590",
      "year": 2023,
      "title": "Die Inhalation von Wasserstoffgas schwächt akute Impulslärm-Traumata ab: Eine präklinische In-vivo-Studie",
      "title_en": "Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study.",
      "title_de": null,
      "journal": "The Annals of otology, rhinology, and laryngology",
      "authors": "Videhult Pierre et al.",
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      "doi": "10.1177/00034894221118764",
      "doi_url": "https://doi.org/10.1177/00034894221118764",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35962590/",
      "url": "https://h2medizin.org/studien/studie-videhultpierre-2023-inhalation-wasserstoffgas-schwaecht-akute/",
      "methods": [
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    },
    {
      "pmid": "36499079",
      "year": 2022,
      "title": "Elektrolytisch reduziertes Wasser, Review I: Molekularer Wasserstoff ist der alleinige Wirkstoff für die therapeutischen Effekte",
      "title_en": "Electrolyzed-Reduced Water: Review I. Molecular Hydrogen Is the Exclusive Agent Responsible for the Therapeutic Effects",
      "title_de": null,
      "journal": "International Journal of Molecular Sciences",
      "authors": "LeBaron et al.",
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      "doi": "10.3390/ijms232314750",
      "doi_url": "https://doi.org/10.3390/ijms232314750",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36499079/",
      "url": "https://h2medizin.org/studien/studie-lebaron-2022-elektrolytisch-reduziertes-wasser-alleiniger-wirkstoff/",
      "methods": [
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      "indications": [
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      "evidence_level": 4,
      "human": false,
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    },
    {
      "pmid": "35920994",
      "year": 2022,
      "title": "Auswirkungen von Nutrazeutika und Nahrungsergänzungsmitteln auf mitochondriale Veränderungen beim gesunden Altern: Eine systematische Übersichtsarbeit randomisierter kontrollierter Studien",
      "title_en": "Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials.",
      "title_de": null,
      "journal": "Aging clinical and experimental research",
      "authors": "Lippi et al.",
      "author_search": "lippi lippi",
      "doi": "10.1007/s40520-022-02203-y",
      "doi_url": "https://doi.org/10.1007/s40520-022-02203-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35920994/",
      "url": "https://h2medizin.org/studien/studie-lippi-2022-auswirkungen-nutrazeutika-nahrungsergaenzungsmitteln-mitochondriale/",
      "methods": [
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        "oxidative-stress"
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    },
    {
      "pmid": "35489460",
      "year": 2022,
      "title": "Elektrokoagulations- und Elektrooxidationstechnologien zur Entfernung von Pestiziden aus Wasser oder Abwasser: Eine Übersichtsarbeit",
      "title_en": "Electrocoagulation and electrooxidation technologies for pesticide removal from water or wastewater: A review.",
      "title_de": null,
      "journal": "Chemosphere",
      "authors": "Biswas et al.",
      "author_search": "biswas biswas",
      "doi": "10.1016/j.chemosphere.2022.134709",
      "doi_url": "https://doi.org/10.1016/j.chemosphere.2022.134709",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35489460/",
      "url": "https://h2medizin.org/studien/studie-biswas-2022-elektrokoagulations-elektrooxidationstechnologien-zur-entfernung/",
      "methods": [
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        "respiratory"
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      "human": false,
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    },
    {
      "pmid": "35340218",
      "year": 2022,
      "title": "Die Rolle von molekularem Wasserstoff beim Altern und alternsbedingten Erkrankungen",
      "title_en": "Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases.",
      "title_de": null,
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Fu et al.",
      "author_search": "fu fu",
      "doi": "10.1155/2022/2249749",
      "doi_url": "https://doi.org/10.1155/2022/2249749",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35340218/",
      "url": "https://h2medizin.org/studien/studie-fu-2022-rolle-beim-altern-alternsbedingten/",
      "methods": [
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    },
    {
      "pmid": "35240982",
      "year": 2022,
      "title": "Molekularer Wasserstoff ist ein potenzielles Schutzmittel im Management der akuten Lungenschädigung",
      "title_en": "Molecular hydrogen is a potential protective agent in the management of acute lung injury.",
      "title_de": null,
      "journal": "Molecular medicine (Cambridge, Mass.)",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1186/s10020-022-00455-y",
      "doi_url": "https://doi.org/10.1186/s10020-022-00455-y",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35240982/",
      "url": "https://h2medizin.org/studien/studie-zhang-2022-ist-potenzielles-schutzmittel-management/",
      "methods": [
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      "human": false,
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    },
    {
      "pmid": "33555824",
      "year": 2022,
      "title": "Der Konsum von wasserstoffreichem Wasser wirkt sich positiv auf Muskelleistung und Laktatantwort aus und lindert den verzögert auftretenden Muskelkater nach Krafttraining",
      "title_en": "Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training",
      "title_de": null,
      "journal": "Journal of Strength and Conditioning Research",
      "authors": "Botek et al.",
      "author_search": "botek botek",
      "doi": "10.1519/jsc.0000000000003979",
      "doi_url": "https://doi.org/10.1519/jsc.0000000000003979",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33555824/",
      "url": "https://h2medizin.org/studien/studie-botek-2022-muskelleistung-verzoegerter-muskelkater-krafttraining/",
      "methods": [
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      "evidence_level": 3,
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    },
    {
      "pmid": "35206179",
      "year": 2022,
      "title": "Molekularer Wasserstoff beeinflusst die körperliche und respiratorische Funktion bei akuten Post-COVID-19-Patienten positiv: eine neue Perspektive in der Rehabilitation",
      "title_en": "Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation",
      "title_de": null,
      "journal": "International Journal of Environmental Research and Public Health",
      "authors": "Botek et al.",
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      "doi": "10.3390/ijerph19041992",
      "doi_url": "https://doi.org/10.3390/ijerph19041992",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35206179/",
      "url": "https://h2medizin.org/studien/studie-botek-2022-post-covid-19-respiratorische-rehabilitation/",
      "methods": [
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        "oxidative-stress",
        "sports-exercise"
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    },
    {
      "pmid": "35276867",
      "year": 2022,
      "title": "Molekularer Wasserstoff mildert den Leistungsabfall bei wiederholten Sprints bei Profi-Fußballern",
      "title_en": "Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players",
      "title_de": null,
      "journal": "Nutrients",
      "authors": "Botek et al.",
      "author_search": "botek botek",
      "doi": "10.3390/nu14030508",
      "doi_url": "https://doi.org/10.3390/nu14030508",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35276867/",
      "url": "https://h2medizin.org/studien/studie-botek-2022-wiederholte-sprints-fussballer/",
      "methods": [
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        "oxidative-stress"
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      "evidence_level": 3,
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    {
      "pmid": "35734974",
      "year": 2022,
      "title": "Eine randomisierte, placebokontrollierte klinische Studie zur Wasserstoff/Sauerstoff-Inhalation bei nicht-alkoholischer Fettlebererkrankung",
      "title_en": "A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease",
      "title_de": null,
      "journal": "Journal of Cellular and Molecular Medicine",
      "authors": "Tao et al.",
      "author_search": "tao tao",
      "doi": "10.1111/jcmm.17456",
      "doi_url": "https://doi.org/10.1111/jcmm.17456",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35734974/",
      "url": "https://h2medizin.org/studien/studie-tao-2022-sauerstoff-inhalation-nicht-alkoholische-fettleber/",
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    {
      "pmid": "36538554",
      "year": 2022,
      "title": "Akute Einnahme von wasserstoffreichem Wasser vor der Belastung verbessert die Laufleistung bei maximaler aerober Geschwindigkeit bei trainierten Leichtathletik-Läufern nicht: eine randomisierte, doppelblinde, placebokontrollierte Crossover-Studie",
      "title_en": "Acute pre-exercise hydrogen rich water intake does not improve running performance at maximal aerobic speed in trained track and field runners: A randomized, double-blind, placebo-controlled crossover study",
      "title_de": null,
      "journal": "PLoS ONE",
      "authors": "Valenta et al.",
      "author_search": "valenta valenta",
      "doi": "10.1371/journal.pone.0279307",
      "doi_url": "https://doi.org/10.1371/journal.pone.0279307",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36538554/",
      "url": "https://h2medizin.org/studien/studie-valenta-2022-vor-belastung-maximale-aerobe-geschwindigkeit-laeufer/",
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    },
    {
      "pmid": "36235628",
      "year": 2022,
      "title": "Die akuten Effekte einer Einzeldosis molekularer Wasserstoff-Supplemente auf die Reaktionen ergogener Anpassungen während hochintensiver intermittierender Belastung beim Menschen",
      "title_en": "The Acute Effects of a Single Dose of Molecular Hydrogen Supplements on Responses to Ergogenic Adjustments during High-Intensity Intermittent Exercise in Humans",
      "title_de": null,
      "journal": "Nutrients",
      "authors": "Alharbi et al.",
      "author_search": "alharbi alharbi",
      "doi": "10.3390/nu14193974",
      "doi_url": "https://doi.org/10.3390/nu14193974",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36235628/",
      "url": "https://h2medizin.org/studien/studie-alharbi-2022-einzeldosis-ergogen-intermittierende-belastung/",
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    },
    {
      "pmid": "36432562",
      "year": 2022,
      "title": "Effekte der intestinalen bakteriellen Wasserstoffgas-Produktion auf die Muskelerholung nach intensiver Belastung bei erwachsenen Männern: eine Pilotstudie",
      "title_en": "Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study",
      "title_de": null,
      "journal": "Nutrients",
      "authors": "Eda et al.",
      "author_search": "eda eda",
      "doi": "10.3390/nu14224875",
      "doi_url": "https://doi.org/10.3390/nu14224875",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36432562/",
      "url": "https://h2medizin.org/studien/studie-eda-2022-intestinale-bakterielle-gasproduktion-muskelerholung/",
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      "h2category": "byproduct"
    },
    {
      "pmid": "36743938",
      "year": 2022,
      "title": "Wirksamkeit und Sicherheit der Wasserstoff-Inhalation als Zusatzbehandlung bei chinesischen Typ-2-Diabetes-Patienten: eine retrospektive, beobachtende, zweiarmige Real-Life-Studie",
      "title_en": "Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study.",
      "title_de": null,
      "journal": "Frontiers in Endocrinology",
      "authors": "Zhao et al.",
      "author_search": "zhao zhao",
      "doi": "10.3389/fendo.2022.1114221",
      "doi_url": "https://doi.org/10.3389/fendo.2022.1114221",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36743938/",
      "url": "https://h2medizin.org/studien/studie-zhao-2022-inhalation-typ-2-diabetes-zusatzbehandlung/",
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      "evidence_level": 2,
      "human": true,
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    {
      "pmid": "36334558",
      "year": 2022,
      "title": "Kurzzeitvorhersage von Rote-Tide-Ereignissen mittels GRU-Netzwerkmodell auf Basis von Multi-Merkmal-Faktoren — Fallstudie im Seegebiet Xiamen",
      "title_en": "Research on red tide short-time prediction using GRU network model based on multi-feature Factors--A case in Xiamen sea area.",
      "title_de": null,
      "journal": "Marine environmental research",
      "authors": "Xiao et al.",
      "author_search": "xiao xiao",
      "doi": "10.1016/j.marenvres.2022.105727",
      "doi_url": "https://doi.org/10.1016/j.marenvres.2022.105727",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36334558/",
      "url": "https://h2medizin.org/studien/studie-xiao-2022-forschung-zur-kurzzeitvorhersage-rote/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "36239123",
      "year": 2022,
      "title": "Bioinspirierter, ultrazäher, hochempfindlicher und quellungsresistenter leitfähiger Hydrogel-Dehnungssensor für Bewegungserkennung und Informationsübertragung",
      "title_en": "A bio-inspired, ultra-tough, high-sensitivity, and anti-swelling conductive hydrogel strain sensor for motion detection and information transmission.",
      "title_de": null,
      "journal": "Materials horizons",
      "authors": "Di et al.",
      "author_search": "di di",
      "doi": "10.1039/d2mh00456a",
      "doi_url": "https://doi.org/10.1039/d2mh00456a",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36239123/",
      "url": "https://h2medizin.org/studien/studie-di-2022-bioinspirierter-ultrazaeher-hochempfindlicher-quellungsresistenter/",
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      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "36210415",
      "year": 2022,
      "title": "Dynamik metabolischer und oxidativer Parameter von Erythrozyten während der Behandlung der chronischen Herzinsuffizienz mit molekularem Wasserstoff.",
      "title_en": "Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.",
      "title_de": null,
      "journal": "Bulletin of experimental biology and medicine",
      "authors": "Deryugina et al.",
      "author_search": "deryugina deryugina",
      "doi": "10.1007/s10517-022-05595-z",
      "doi_url": "https://doi.org/10.1007/s10517-022-05595-z",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36210415/",
      "url": "https://h2medizin.org/studien/studie-deryugina-2022-dynamik-metabolischer-oxidativer-parameter/",
      "methods": [
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      "evidence_level": 2,
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    },
    {
      "pmid": "36190308",
      "year": 2022,
      "title": "Verwendung eines Hochdurchsatz-Ganzzell-Hydrogenase-Assays zur Identifizierung potenzieller niedermolekularer Inhibitoren der [NiFe]-Hydrogenase",
      "title_en": "Using a high-throughput, whole-cell hydrogenase assay to identify potential small molecule inhibitors of [NiFe]-hydrogenase.",
      "title_de": null,
      "journal": "Metallomics : integrated biometal science",
      "authors": "Sebastiampillai et al.",
      "author_search": "sebastiampillai sebastiampillai",
      "doi": "10.1093/mtomcs/mfac073",
      "doi_url": "https://doi.org/10.1093/mtomcs/mfac073",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36190308/",
      "url": "https://h2medizin.org/studien/studie-sebastiampillai-2022-verwendung-hochdurchsatz-ganzzell-hydrogenase/",
      "methods": [
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      "indications": [
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      "evidence_level": 1,
      "human": false,
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    },
    {
      "pmid": "36167814",
      "year": 2022,
      "title": "Photokatalytische Glukosedepletion und Wasserstofferzeugung zur diabetischen Wundheilung",
      "title_en": "Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing.",
      "title_de": null,
      "journal": "Nature communications",
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      "year": 2022,
      "title": "Dehydrochlorierung von PCDDs an SWCN-getragenen Ni₁₀- und Ni₁₃-Clustern: Eine DFT-Studie",
      "title_en": "Dehydrochlorination of PCDDs on SWCN-Supported Ni10 and Ni13 Clusters, a DFT Study.",
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      "journal": "Molecules (Basel, Switzerland)",
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      "year": 2022,
      "title": "Wasserstofferzeugung aus Harnstoff im menschlichen Urin unter Verwendung getrennter Systeme",
      "title_en": "Hydrogen production from urea in human urine using segregated systems.",
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      "journal": "Water research",
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      "year": 2022,
      "title": "Bericht über die Wasserstofftherapie und ihre klinischen Anwendungen: Sicherheit und Wirksamkeit",
      "title_en": "Narrative on Hydrogen Therapy and its Clinical Applications: Safety and Efficacy.",
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      "journal": "Current pharmaceutical design",
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    {
      "pmid": "35843727",
      "year": 2022,
      "title": "Eine potenzielle klinische Anwendung von wasserstoffreicher Kochsalzlösung bei Patienten mit Schädel-Hirn-Trauma.",
      "title_en": "A potential clinical application of hydrogen-rich saline in patients with traumatic brain injury.",
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      "journal": "Journal of pediatric surgery",
      "authors": "Benjamin et al.",
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      "year": 2022,
      "title": "Mikrobielle Wasserstoff-„Manufaktur” für verbesserte Gastherapie und selbstaktivierte Immuntherapie durch reduziertes Immune Escape",
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      "journal": "Journal of nanobiotechnology",
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    {
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      "year": 2022,
      "title": "Wasserstoff hilft, die durch Staphylococcus aureus induzierte Mastitis bei Mäusen zu lindern",
      "title_en": "Hydrogen helps to ameliorate Staphylococcus aureus-induced mastitis in mice.",
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      "year": 2022,
      "title": "Wasserstoffreiches Wasser als diätetischer Aktivator von braunem Fettgewebe und UCP1?",
      "title_en": "Hydrogen-Rich Water as a Dietary Activator of Brown Adipose Tissue and UCP1?",
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      "year": 2022,
      "title": "Radiographische Merkmale der Resorption von magnesiumbasierten bioresorbierbaren Schrauben bei pädiatrischen Frakturen",
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      "year": 2022,
      "title": "Entwicklung eines Modellsystems für das Verhalten der Gashohlraumbildung bei der Implantation von Magnesiumlegierungen",
      "title_en": "Development of a Model System for Gas Cavity Formation Behavior of Magnesium Alloy Implantation.",
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      "journal": "ACS biomaterials science & engineering",
      "authors": "Yamamoto et al.",
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      "title": "Kurzfristiger Konsum von wasserstoffreichem Wasser verbessert die Kraftleistung und die Herzfrequenzerholung bei Drachenboot-Athleten",
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      "year": 2022,
      "title": "Metabolische Synergie zwischen den menschlichen Symbionten Bacteroides und Methanobrevibacter",
      "title_en": "Metabolic Synergy between Human Symbionts Bacteroides and Methanobrevibacter.",
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    {
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      "year": 2022,
      "title": "Magnesium-Galvanikzellen erzeugen Wasserstoff und modulieren die Tumormikroumgebung, um das Krebswachstum zu hemmen",
      "title_en": "Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth.",
      "title_de": null,
      "journal": "Nature communications",
      "authors": "Yang et al.",
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      "year": 2022,
      "title": "Die lokale Behandlung mit wasserstoffreicher Kochsalzlösung fördert die Wundheilung in vivo durch Hemmung des oxidativen Stresses über den Nrf-2/HO-1-Signalweg",
      "title_en": "Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative Stress via Nrf-2/HO-1 Pathway.",
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      "year": 2022,
      "title": "Die langfristige und tägliche Anwendung von molekularem Wasserstoff induziert eine Reprogrammierung des Leberstoffwechsels bei Ratten durch Modulation der NADP/NADPH-Redox-Signalwege",
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      "title": "Wasserstoffreiches Wasser kann die Bildung biogener Amine in Butter reduzieren",
      "title_en": "Hydrogen-rich water can reduce the formation of biogenic amines in butter.",
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      "pmid": "35187885",
      "year": 2022,
      "title": "Molekularer Wasserstoff ist ein vielversprechendes Therapeutikum für Lungenerkrankungen",
      "title_en": "Molecular hydrogen is a promising therapeutic agent for pulmonary disease.",
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      "journal": "Journal of Zhejiang University. Science. B",
      "authors": "Fu et al.",
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      "doi": "10.1631/jzus.b2100420",
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    {
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      "title": "Quantifizierung von gelöstem H₂ und kontinuierliche Überwachung von wasserstoffreichem Wasser für Hämodialyseanwendungen: Eine experimentelle Studie",
      "title_en": "Quantification of dissolved H2 and continuous monitoring of hydrogen-rich water for haemodialysis applications: An experimental study.",
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      "journal": "The International journal of artificial organs",
      "authors": "Mouzakis et al.",
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    {
      "pmid": "35025709",
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      "title": "Die mikrobielle Wasserstoffökonomie lindert Kolitis durch Reprogrammierung des Kolonozytenstoffwechsels und Stärkung der Darmbarriere",
      "title_en": "Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier.",
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      "journal": "Gut microbes",
      "authors": "Ge et al.",
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      "doi": "10.1080/19490976.2021.2013764",
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      "url": "https://h2medizin.org/studien/studie-ge-2022-mikrobielle-wasserstoffoekonomie-lindert-kolitis/",
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      "title": "Geschlechtsspezifische Unterschiede in den neuroprotektiven Wirkungen von Wasserstoffgas gegen durch intrazerebrale Blutung induzierte Depression",
      "title_en": "Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression.",
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      "journal": "Neurochemistry international",
      "authors": "An et al.",
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      "doi": "10.1016/j.neuint.2022.105276",
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      "title": "In-vivo-Mikroelektroden-Überwachung der Echtzeit-Wasserstoffkonzentration in verschiedenen Geweben von Ratten nach Inhalation von Wasserstoffgas",
      "title_en": "In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas.",
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      "journal": "Medical gas research",
      "authors": "Liu et al.",
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      "year": 2022,
      "title": "Wasserstoffreiches Bad mit nanogroßen Bläschen verbessert die antioxidative Kapazität und die Entzündungswerte im menschlichen Serum",
      "title_en": "Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum.",
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      "journal": "Medical gas research",
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      "url": "https://h2medizin.org/studien/studie-tanaka-2022-bad-nanogrossen-blaeschen-verbessert/",
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      "title": "Metallorganische-Gerüstverbindungs-basierte Wasserstofffreisetzungsplattform für eine multieffektive zielgerichtete Helicobacter-pylori-Therapie und intestinale-Flora-schützende Fähigkeiten",
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      "journal": "Advanced materials (Deerfield Beach, Fla.)",
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    {
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      "title": "Regulation des Chlorothalonil-Abbaus durch molekularen Wasserstoff",
      "title_en": "Regulation of chlorothalonil degradation by molecular hydrogen.",
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      "year": 2022,
      "title": "Molekularer Wasserstoff unterdrückt die durch Porphyromonas-gingivalis-Lipopolysaccharid induzierte Erhöhung der Interleukin-1-alpha- und Interleukin-6-Sekretion in menschlichen Zahnfleischzellen.",
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      "url": "https://h2medizin.org/studien/studie-saitoh-2022-unterdrueckt-porphyromonas-gingivalis-lipopolysaccharid/",
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      "year": 2022,
      "title": "Wasserstoffreiches Wasser reduzierte oxidativen Stress und renale Fibrose bei Ratten mit einseitiger Ureterobstruktion.",
      "title_en": "Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral obstruction.",
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      "year": 2022,
      "title": "Molekularer Wasserstoff hat durch die Verbesserung der Mitochondrienfunktion und immunmodulatorische Effekte auf T-Zellen einen positiven Einfluss auf den Schwangerschaftserhalt",
      "title_en": "Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells",
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      "title": "Perspektive des molekularen Wasserstoffs in der Behandlung der Sepsis",
      "title_en": "Perspective of Molecular Hydrogen in the Treatment of Sepsis",
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      "journal": "Current Pharmaceutical Design",
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    {
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      "year": 2021,
      "title": "Neuroprotektive und präventive Effekte des molekularen Wasserstoffs",
      "title_en": "Neuroprotective and Preventative Effects of Molecular Hydrogen",
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    {
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      "year": 2021,
      "title": "Sphingomyelin der Zelloberfläche: Schlüsselrolle bei Krebsentstehung, -progression und Immunevasion.",
      "title_en": "Cell surface sphingomyelin: key role in cancer initiation, progression, and immune evasion.",
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    {
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      "title": "Bekämpfung von oxidativem Stress und Entzündung bei COVID-19 durch molekulare Wasserstofftherapie: Mechanismen und Perspektiven.",
      "title_en": "Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives.",
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      "title": "Strukturelle Polymorphie von Amyloid β, assoziierte Toxizität und therapeutische Strategien.",
      "title_en": "Amyloid β structural polymorphism, associated toxicity and therapeutic strategies.",
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      "authors": "Oren et al.",
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    {
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      "title": "Darmmikrobiota von Sportlern.",
      "title_en": "[Intestinal microbiote of athletes].",
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      "journal": "Voprosy pitaniia",
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    {
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      "year": 2021,
      "title": "Molekularer Wasserstoff als neuartiges Antitumormittel: Mögliche zugrunde liegende Mechanismen der Genexpression.",
      "title_en": "Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression.",
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      "title": "Molekularer Wasserstoff als neuartiges Schutzmittel gegen präsymptomatische Erkrankungen.",
      "title_en": "Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases.",
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      "title": "Wie das Gehirn die Toxizität von Fettsäuren bekämpft.",
      "title_en": "How the brain fights fatty acids' toxicity.",
      "title_de": null,
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    {
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      "title": "Molekularer Wasserstoff als potenziell klinisch anwendbares Radioprotektivum.",
      "title_en": "Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.",
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    {
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      "title": "Schützende Wirkungen von molekularem Wasserstoff auf Lungenschäden bei Lungentransplantation.",
      "title_en": "Protective effects of molecular hydrogen on lung injury from lung transplantation.",
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      "authors": "Quan et al.",
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    {
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      "title": "Mögliche therapeutische Anwendungen von Wasserstoff bei chronisch-entzündlichen Erkrankungen: Mögliche hemmende Rolle bei mitochondrialem Stress.",
      "title_en": "Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress.",
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    {
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      "title": "Inhalierte Gase als neuartige neuroprotektive Therapien in der Phase nach Herzstillstand.",
      "title_en": "Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period.",
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    {
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      "title": "Wasserstoffbehandlung: eine neuartige Option bei Lebererkrankungen.",
      "title_en": "Hydrogen treatment: a novel option in liver diseases.",
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      "title": "Chemische und biochemische Aspekte von molekularem Wasserstoff bei der Behandlung des Kawasaki-Syndroms und von COVID-19.",
      "title_en": "Chemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID-19.",
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      "authors": "Chen et al.",
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      "title": "Wasserstoffgas: Ein neuartiger Typ von Antioxidans bei der Modulation der Homöostase der Geschlechtsorgane.",
      "title_en": "Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.",
      "title_de": null,
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      "authors": "Zhang et al.",
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      "doi": "10.1155/2021/8844346",
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      "title": "Wasserstoffgas-Therapie: Von präklinischen Studien zu klinischen Studien.",
      "title_en": "Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.",
      "title_de": null,
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    {
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      "year": 2021,
      "title": "Wasserstoff – allgemein anwendbar von der Medizin bis zur Landwirtschaft: Von molekularen Mechanismen bis zur Praxis.",
      "title_en": "Hydrogen Commonly Applicable from Medicine to Agriculture: From Molecular Mechanisms to the Field.",
      "title_de": null,
      "journal": "Current pharmaceutical design",
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      "url": "https://h2medizin.org/studien/studie-li-2021-allgemein-anwendbar-medizin-bis/",
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    {
      "pmid": "33185158",
      "year": 2021,
      "title": "Wasserstoffinduzierte Neuroprotektion bei neonataler hypoxisch-ischämischer Enzephalopathie.",
      "title_en": "Hydrogen-induced Neuroprotection in Neonatal Hypoxic-ischemic Encephalopathy.",
      "title_de": null,
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    {
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      "year": 2021,
      "title": "Aktuelle Fortschritte in der Forschung zu molekularem Wasserstoff zur Reduktion von belastungsinduziertem oxidativem Stress und Entzündung.",
      "title_en": "Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation.",
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    {
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      "year": 2021,
      "title": "Ein Überblick über Ovarialkarzinom: Beteiligte molekulare Prozesse und Entwicklung zielgerichteter Chemotherapeutika.",
      "title_en": "An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics.",
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    {
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      "year": 2021,
      "title": "Aktuelle Fortschritte in Studien zu molekularem Wasserstoff bei der Behandlung der Pankreatitis.",
      "title_en": "Recent advances in studies of molecular hydrogen in the treatment of pancreatitis.",
      "title_de": null,
      "journal": "Life sciences",
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    {
      "pmid": "33078374",
      "year": 2021,
      "title": "Neuroprotektive Wirkungen von molekularem Wasserstoff: Eine kritische Übersichtsarbeit.",
      "title_en": "Neuroprotective Effects of Molecular Hydrogen: A Critical Review.",
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      "journal": "Neuroscience bulletin",
      "authors": "Chen et al.",
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      "doi": "10.1007/s12264-020-00597-1",
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    {
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      "year": 2021,
      "title": "Die Rolle von molekularem Wasserstoff bei Hauterkrankungen und seine Auswirkung auf die Schönheit.",
      "title_en": "Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty.",
      "title_de": null,
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      "authors": "Bajgai et al.",
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    {
      "pmid": "32767925",
      "year": 2021,
      "title": "Direkte Zielstrukturen und nachgeschaltete Signalwege, über die molekularer Wasserstoff vielfältige Funktionen ausübt: Mit Fokus auf Eingriffe in Radikalreaktionen",
      "title_en": "Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions.",
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      "journal": "Current pharmaceutical design",
      "authors": "Ohta",
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    {
      "pmid": "32505123",
      "year": 2021,
      "title": "Wasserstoff und therapeutische Gase bei neonataler hypoxisch-ischämischer Enzephalopathie: potenzielle neuroprotektive Zusatztherapien in der translationalen Forschung",
      "title_en": "Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.",
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      "authors": "Htun et al.",
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      "url": "https://h2medizin.org/studien/studie-htun-2021-therapeutische-gase-neonataler-hypoxisch/",
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    {
      "pmid": "33356580",
      "year": 2021,
      "title": "Hydrotherapie mit wasserstoffreichem Wasser im Vergleich zum RICE-Protokoll nach akuter Knöchelverstauchung bei Profisportlern: eine randomisierte Nicht-Unterlegenheits-Pilotstudie",
      "title_en": "Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial",
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      "url": "https://h2medizin.org/studien/studie-javorac-2021-knoechelverstauchung-rice-protokoll-profisportler/",
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    {
      "pmid": "33573133",
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      "title": "Anwendung von molekularem Wasserstoff als Antioxidans bei den Reaktionen von Atmung und ergogenen Anpassungen während stufenweiser Belastung beim Menschen",
      "title_en": "Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Incremental Exercise in Humans",
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    {
      "pmid": "34319514",
      "year": 2021,
      "title": "Randomisierte doppelblinde placebokontrollierte Studie zur Wasserstoff-Inhalation bei der Parkinson-Krankheit: eine Pilotstudie",
      "title_en": "Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a pilot study",
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      "authors": "Yoritaka et al.",
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      "year": 2021,
      "title": "Intravenöse Wasserstofftherapie mit intrazisternaler Magnesiumsulfat-Infusion bei schwerer aneurysmatischer Subarachnoidalblutung",
      "title_en": "Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage.",
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      "pmid": "33454037",
      "year": 2021,
      "title": "Wärmespeichernde Effekte eines Bades mit wasserstoffreichem Wasser, mittels Thermografie beim Menschen untersucht",
      "title_en": "Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans",
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    {
      "pmid": "33530211",
      "year": 2021,
      "title": "Auswirkungen der kombinierten Anwendung von Wasserstoffwasser und Photobiomodulation auf die Parkinson-Krankheit: Eine Pilotstudie",
      "title_en": "Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study",
      "title_de": null,
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      "authors": "Hong et al.",
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      "doi": "10.1097/md.0000000000024191",
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    {
      "pmid": "33742060",
      "year": 2021,
      "title": "Randomisierte Crossover-Studie zur klinischen Wirksamkeit an Mensch und Maus zur Förderung der Tränensekretion und zum Schutz der Tränendrüse durch molekularen Wasserstoff",
      "title_en": "Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen",
      "title_de": null,
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      "authors": "Kubota et al.",
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      "year": 2021,
      "title": "Schützende Wirkungen der Wasserstoffgas-Inhalation auf strahleninduzierte Knochenmarkschäden bei Krebspatienten: eine retrospektive Beobachtungsstudie",
      "title_en": "Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study",
      "title_de": null,
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    {
      "pmid": "34601077",
      "year": 2021,
      "title": "Die Wirkungen einer 6-monatigen Einnahme von wasserstoffreichem Wasser auf molekulare und phänotypische Biomarker des Alterns bei älteren Erwachsenen ab 70 Jahren: Eine randomisierte kontrollierte Pilotstudie",
      "title_en": "The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial",
      "title_de": null,
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    {
      "pmid": "35046230",
      "year": 2021,
      "title": "Zusammenhang der Wasserstoffkonzentration in der Atemluft mit oraler Nahrungsaufnahme und Harnwegserkrankungen",
      "title_en": "[ASSOCIATION OF BREATH HYDROGEN CONCENTRATION WITH ORAL INTAKE AND URINARY DISEASES].",
      "title_de": null,
      "journal": "Nihon Hinyokika Gakkai zasshi. The japanese journal of urology",
      "authors": "Sugaya et al.",
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    {
      "pmid": "34830187",
      "year": 2021,
      "title": "Ammoniumformiat-Pd/C als neues Reduktionssystem für 1,2,4-Oxadiazole: Synthese von Guanidin-Derivaten und reduktive Umlagerung zu Chinazolin-4-onen mit potenzieller antidiabetischer Aktivität",
      "title_en": "Ammonium Formate-Pd/C as a New Reducing System for 1,2,4-Oxadiazoles. Synthesis of Guanidine Derivatives and Reductive Rearrangement to Quinazolin-4-Ones with Potential Anti-Diabetic Activity.",
      "title_de": null,
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      "authors": "Marzullo et al.",
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      "doi": "10.3390/ijms222212301",
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      "url": "https://h2medizin.org/studien/studie-marzullo-2021-ammoniumformiat-neues-reduktionssystem-oxadiazole/",
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    {
      "pmid": "34781966",
      "year": 2021,
      "title": "Wasserstoffgas in Kombination mit extrakorporaler kardiopulmonaler Reanimation verbessert das Überleben nach längerem Herzstillstand bei Ratten",
      "title_en": "Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats.",
      "title_de": null,
      "journal": "Journal of translational medicine",
      "authors": "Yin et al.",
      "author_search": "yin yin",
      "doi": "10.1186/s12967-021-03129-1",
      "doi_url": "https://doi.org/10.1186/s12967-021-03129-1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/34781966/",
      "url": "https://h2medizin.org/studien/studie-yin-2021-wasserstoffgas-kombination-extrakorporaler-kardiopulmonaler/",
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    {
      "pmid": "34674744",
      "year": 2021,
      "title": "Wirkung der Inhalation von Wasserstoffgas auf die Lebensqualität von Patienten nach Hepatektomie: Protokoll für eine randomisierte kontrollierte Studie",
      "title_en": "Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized controlled trial.",
      "title_de": null,
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    {
      "pmid": "34645100",
      "year": 2021,
      "title": "Ein H₂-angereichertes, Stickstoffmonoxid-produzierendes funktionelles Getränk als neuroprotektives Mittel bei Schädel-Hirn-Traumata und Gehirnerschütterungen",
      "title_en": "An H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussions.",
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      "authors": "LeBaron et al.",
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    {
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      "year": 2021,
      "title": "Erwiderung auf „Diskussion: Das Trinken von Wasserstoffwasser steigert die Ausdauer und lindert psychometrische Erschöpfung: eine randomisierte, doppelblinde, placebokontrollierte Studie”",
      "title_en": "Reply to \"Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study\".",
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    {
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      "year": 2021,
      "title": "Diskussion: Das Trinken von Wasserstoffwasser steigert die Ausdauer und lindert psychometrische Erschöpfung: eine randomisierte, doppelblinde, placebokontrollierte Studie",
      "title_en": "Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study.",
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      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "Falster et al.",
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      "doi": "10.1139/cjpp-2021-0031",
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    {
      "pmid": "34524338",
      "year": 2021,
      "title": "In-situ-Wasserstoff-Nanogenerator für bimodal bildgebungsgeführte synergistische photothermische/Wasserstoff-Therapien",
      "title_en": "In situ hydrogen nanogenerator for bimodal imaging guided synergistic photothermal/hydrogen therapies.",
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    {
      "pmid": "34513069",
      "year": 2021,
      "title": "Anwendung von molekularem Wasserstoff in der Herzchirurgie unter Einsatz der Herz-Lungen-Maschine",
      "title_en": "Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass.",
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    {
      "pmid": "34426524",
      "year": 2021,
      "title": "H₂ in antarktischer Firnluft: Atmosphärische Rekonstruktionen und Implikationen für anthropogene Emissionen",
      "title_en": "H2 in Antarctic firn air: Atmospheric reconstructions and implications for anthropogenic emissions.",
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      "journal": "Proceedings of the National Academy of Sciences of the United States of America",
      "authors": "Patterson et al.",
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    {
      "pmid": "34328487",
      "year": 2021,
      "title": "Ein PdMo-Bimetallen mit präziser Wellenlängenanpassung und Katalyse für synergistische photothermische Ablation und Wasserstofftherapie von Krebs in unterschiedlichen Tiefen",
      "title_en": "A PdMo bimetallene with precise wavelength adjustment and catalysis for synergistic photothermal ablation and hydrogen therapy of cancer at different depths.",
      "title_de": null,
      "journal": "Journal of materials chemistry. B",
      "authors": "Bai et al.",
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      "doi": "10.1039/d1tb01284c",
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    {
      "pmid": "34251693",
      "year": 2021,
      "title": "Die Sicherheit der Elektrooxidation zur Harnstoffentfernung in einer tragbaren künstlichen Niere wird durch die Bildung von Glukose-Abbauprodukten beeinträchtigt",
      "title_en": "Safety of electrooxidation for urea removal in a wearable artificial kidney is compromised by formation of glucose degradation products.",
      "title_de": null,
      "journal": "Artificial organs",
      "authors": "van Gelder et al.",
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    {
      "pmid": "34120062",
      "year": 2021,
      "title": "Mikrobielle Nahrung aus Licht, Kohlendioxid und Wasserstoffgas: Kinetisches, stöchiometrisches und ernährungsphysiologisches Potenzial dreier Purpurbakterien",
      "title_en": "Microbial food from light, carbon dioxide and hydrogen gas: Kinetic, stoichiometric and nutritional potential of three purple bacteria.",
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      "year": 2021,
      "title": "Die Umgestaltung des bakteriellen Stoffwechsels von molekularem Wasserstoff trägt zum Auswachsen kommensaler E. coli während einer Darmentzündung bei",
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      "journal": "eLife",
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      "title": "Mechanismus der Wasserstoff-vermittelten Unterdrückung von Gebärmutterhalskrebs, aufgedeckt durch Hochdurchsatz-RNA-Sequenzierung",
      "title_en": "Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing.",
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      "authors": "Chu et al.",
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      "title": "Wirkungen von Wasserstoff als adjuvante Behandlung bei instabiler Angina pectoris",
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      "title": "Molekularer Wasserstoff lindert Asthma durch Hemmung der IL-33/ILC2-Achse",
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      "year": 2021,
      "title": "Untersuchungen zu Dianhydro-D-glucitol, adsorbiert an der Oberfläche von AuNPs: In-silico- und In-vitro-Ansatz auf Basis von Antikrebsaktivitätsstudien gegen A549-Lungenkrebszelllinien",
      "title_en": "Investigations of Dianhydro-D-glucitol adsorbed on AuNPs surface: In silico and in vitro approach based on anticancer activity studies against A549 lung cancer cell lines.",
      "title_de": null,
      "journal": "Journal of molecular recognition : JMR",
      "authors": "V et al.",
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      "year": 2021,
      "title": "Wasserstoff mindert endotoxininduzierte Lungenschäden durch Aktivierung von Thioredoxin 1 und Senkung der Expression von Gewebefaktor",
      "title_en": "Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression.",
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      "year": 2021,
      "title": "Hochfluss-Wasserstoffinhalation könnte die Immunfunktion von Teilnehmern mittleren Alters unterdrücken: eine eigenkontrollierte Studie",
      "title_en": "High-flow hydrogen inhalation might suppresses the immune function of middle-aged participants: a self-controlled study.",
      "title_de": null,
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      "authors": "Chen et al.",
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      "year": 2021,
      "title": "Wasserstoffgas-Therapie schwächt die Signalübertragung des Entzündungswegs bei septischen Mäusen ab",
      "title_en": "Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice.",
      "title_de": null,
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      "authors": "Matsuura et al.",
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      "doi": "10.1016/j.jss.2021.01.022",
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    {
      "pmid": "33485760",
      "year": 2021,
      "title": "Wasserstoff als potenzielles Therapeutikum bei Adipositas: Das Gehirn als Zielstruktur",
      "title_en": "Hydrogen as a Potential Therapeutic in Obesity: Targeting the Brain.",
      "title_de": null,
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      "authors": "Ostojic",
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      "year": 2021,
      "title": "Auf dem Weg zur Anpassung der Abbaurate magnesiumbasierter Biomaterialien für verschiedene medizinische Anwendungen: Bewertung von Korrosion, Zytokompatibilität und immunologischen Effekten",
      "title_en": "Toward Tailoring the Degradation Rate of Magnesium-Based Biomaterials for Various Medical Applications: Assessing Corrosion, Cytocompatibility and Immunological Effects.",
      "title_de": null,
      "journal": "International journal of molecular sciences",
      "authors": "Hartjen et al.",
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      "doi": "10.3390/ijms22020971",
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      "year": 2021,
      "title": "Die Prävalenz der intestinalen Dysbiose bei Patienten, die zur Antireflux-Chirurgie überwiesen wurden",
      "title_en": "The prevalence of intestinal dysbiosis in patients referred for antireflux surgery.",
      "title_de": null,
      "journal": "Surgical endoscopy",
      "authors": "Haworth et al.",
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      "year": 2021,
      "title": "Dechloromonas und nahe Verwandte dominieren während der hydrogenotrophen Denitrifikation in stimulierten Mikrokosmen mit oxischem Aquifermaterial",
      "title_en": "Dechloromonas and close relatives prevail during hydrogenotrophic denitrification in stimulated microcosms with oxic aquifer material.",
      "title_de": null,
      "journal": "FEMS microbiology ecology",
      "authors": "Duffner et al.",
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      "doi": "10.1093/femsec/fiab004",
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      "url": "https://h2medizin.org/studien/studie-duffner-2021-dechloromonas-nahe-verwandte-dominieren/",
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    {
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      "year": 2021,
      "title": "Karzinostatische Wirkungen von Alkanoylascorbat plus Platin-Nanokolloid und Stabilisierung des esterolytisch entstandenen Ascorbats durch Wasserstoff",
      "title_en": "Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen.",
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    {
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      "year": 2021,
      "title": "Molekularer Wasserstoff (H₂) als potenzielle Behandlung bei akuter und chronischer Erschöpfung",
      "title_en": "Molecular hydrogen (H2 ) as a potential treatment for acute and chronic fatigue.",
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    {
      "pmid": "33246703",
      "year": 2021,
      "title": "Kobaltmodifiziertes 2D-poröses organisches Polymer zur hocheffizienten elektrokatalytischen Entfernung von toxischem Harnstoff und Nitrophenol",
      "title_en": "Cobalt-modified 2D porous organic polymer for highly efficient electrocatalytic removal of toxic urea and nitrophenol.",
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    {
      "pmid": "33231266",
      "year": 2021,
      "title": "Wasserstoffreiches Wasser mindert die durch Tritiumexposition induzierte Radiotoxizität in vitro und in vivo",
      "title_en": "Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo.",
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    {
      "pmid": "33151329",
      "year": 2021,
      "title": "Wasserstofftherapie als wirksame und neuartige adjuvante Behandlung gegen COVID-19",
      "title_en": "Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19.",
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      "year": 2021,
      "title": "Antwort auf: Wasserstofftherapie als wirksame und neuartige adjuvante Behandlung gegen COVID-19",
      "title_en": "Response to: Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19.",
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    {
      "pmid": "32962610",
      "year": 2021,
      "title": "Wasserstoffgas als exotisches leistungssteigerndes Mittel: Herausforderungen und Chancen",
      "title_en": "Hydrogen Gas as an Exotic Performance-Enhancing Agent: Challenges and Opportunities.",
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    {
      "pmid": "32954996",
      "year": 2021,
      "title": "Oxidativer Stress und Wirkmechanismen von molekularem Wasserstoff in der Medizin",
      "title_en": "Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine.",
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    {
      "pmid": "32940172",
      "year": 2021,
      "title": "Anwendung von molekularem Wasserstoff beim Schlaganfall: Von der Forschung zur klinischen Praxis",
      "title_en": "Molecular Hydrogen Application in Stroke: Bench to Bedside.",
      "title_de": null,
      "journal": "Current pharmaceutical design",
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    {
      "pmid": "32632247",
      "year": 2021,
      "title": "Belebt das Trinken von wasserstoffgasreichem Wasser den Hypometabolismus des Gehirns bei Neurodegeneration durch Hochregulation von SCFAs?",
      "title_en": "Does drinking water rich in hydrogen gas revive brain hypometabolism in neurodegeneration by SCFAs upregulation?",
      "title_de": null,
      "journal": "European journal of clinical nutrition",
      "authors": "Ostojic",
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      "doi": "10.1038/s41430-020-0680-x",
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    {
      "pmid": "32763820",
      "year": 2020,
      "title": "Molekularer Wasserstoff: Ein potenzielles Strahlenschutzmittel",
      "title_en": "Molecular hydrogen: A potential radioprotective agent",
      "title_de": null,
      "journal": "Biomedicine & Pharmacotherapy",
      "authors": "Hu et al.",
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      "doi": "10.1016/j.biopha.2020.110589",
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    {
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      "title": "Perspektiven von molekularem Wasserstoff im perioperativen Nervenschutz: von der Grundlagenforschung zur klinischen Anwendung",
      "title_en": "Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application",
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    {
      "pmid": "33004714",
      "year": 2020,
      "title": "Vorschlag einer medizinischen Versorgung der nächsten Generation: „Mega-Wasserstoff-Therapie”",
      "title_en": "Proposal of next-generation medical care \"Mega-hydrogen Therapy\".",
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      "authors": "Ichikawa et al.",
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    {
      "pmid": "32729851",
      "year": 2020,
      "title": "Katalytische reduktive Aminierungen unter Verwendung von molekularem Wasserstoff zur Synthese verschiedener Arten von Aminen",
      "title_en": "Catalytic reductive aminations using molecular hydrogen for synthesis of different kinds of amines.",
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    {
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      "year": 2020,
      "title": "Ein „philosophisches Molekül“: Wasserstoff könnte Seneszenz und hartnäckige Erkrankungen überwinden",
      "title_en": "A \"philosophical molecule,\" hydrogen may overcome senescence and intractable diseases.",
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      "authors": "Hirano et al.",
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    {
      "pmid": "32097610",
      "year": 2020,
      "title": "Die Zukunft der Kryoablation: Ein abskopaler Effekt",
      "title_en": "The future of cryoablation: An abscopal effect.",
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      "journal": "Cryobiology",
      "authors": "Chen et al.",
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    {
      "pmid": "32015786",
      "year": 2020,
      "title": "Anwendung von molekularem Wasserstoff als neuartiges Antioxidans in der Sportwissenschaft",
      "title_en": "Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science.",
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      "authors": "Kawamura et al.",
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    {
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      "year": 2020,
      "title": "Stoffwechsel von molekularem Wasserstoff: ein weit verbreitetes Merkmal pathogener Bakterien und Protisten",
      "title_en": "Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists.",
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      "authors": "Benoit et al.",
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    {
      "pmid": "31675478",
      "year": 2020,
      "title": "Die akute Einnahme von wasserstoffreichem Wasser verbessert die ansteigende Laufleistung auf dem Laufband bei ausdauertrainierten Athleten nicht",
      "title_en": "Acute ingestion of hydrogen-rich water does not improve incremental treadmill running performance in endurance-trained athletes",
      "title_de": null,
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      "authors": "Ooi et al.",
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      "doi": "10.1139/apnm-2019-0553",
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    {
      "pmid": "32470022",
      "year": 2020,
      "title": "Die periphere Endothelfunktion kann durch den täglichen Konsum von Wasser mit über 7 ppm gelöstem Wasserstoff verbessert werden: Eine randomisierte kontrollierte Studie",
      "title_en": "Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial",
      "title_de": null,
      "journal": "PLoS One",
      "authors": "Ishibashi et al.",
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      "doi": "10.1371/journal.pone.0233484",
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    {
      "pmid": "32699287",
      "year": 2020,
      "title": "Wasserstoffreiches Wasser reduziert Entzündungsreaktionen und verhindert die Apoptose peripherer Blutzellen bei gesunden Erwachsenen: eine randomisierte, doppelblinde, kontrollierte Studie",
      "title_en": "Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial",
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      "authors": "Sim et al.",
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      "doi": "10.1038/s41598-020-68930-2",
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    {
      "pmid": "33380581",
      "year": 2020,
      "title": "Auswirkungen der Inhalation eines wasserstoffreichen Gasgemischs über eine Nasenkanüle während der Erholungsphase nach dem Sport auf den nachfolgenden oxidativen Stress, die Muskelschädigung und die sportlichen Leistungen bei Männern",
      "title_en": "Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men",
      "title_de": null,
      "journal": "Medical Gas Research",
      "authors": "Shibayama et al.",
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      "doi": "10.4103/2045-9912.304222",
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      "url": "https://h2medizin.org/studien/studie-shibayama-2020-nasenkanuele-erholung-nach-sport-muskelschaedigung/",
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      "h2category": "therapy"
    },
    {
      "pmid": "33380582",
      "year": 2020,
      "title": "Eine zweiwöchige kontinuierliche Supplementierung mit wasserstoffreichem Wasser erhöht die maximale Sauerstoffaufnahme während eines ansteigenden Radergometer-Belastungstests bei gesunden Menschen: eine randomisierte, einfach-verblindete, placebokontrollierte Studie",
      "title_en": "Two-week continuous supplementation of hydrogen-rich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study",
      "title_de": null,
      "journal": "Medical Gas Research",
      "authors": "Hori et al.",
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      "doi": "10.4103/2045-9912.304223",
      "doi_url": "https://doi.org/10.4103/2045-9912.304223",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33380582/",
      "url": "https://h2medizin.org/studien/studie-hori-2020-maximale-sauerstoffaufnahme-radergometer-test/",
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    {
      "pmid": "32791592",
      "year": 2020,
      "title": "Veränderungen des nasalen Stickstoffmonoxids bei der Behandlung der allergischen Rhinitis mit wasserstoffreicher Nasenspülung",
      "title_en": "[Changes of nasal nitric oxide in the treatment of allergic rhinitis with hydrogen-rich saline lavage of nasal cavity].",
      "title_de": null,
      "journal": "Lin chuang er bi yan hou tou jing wai ke za zhi (Journal of Clinical Otorhinolaryngology Head and Neck Surgery)",
      "authors": "Jin et al.",
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      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32791592/",
      "url": "https://h2medizin.org/studien/studie-jin-2020-allergische-rhinitis-nasenspuelung/",
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    },
    {
      "pmid": "33324415",
      "year": 2020,
      "title": "Wasserstoff bei Patienten mit kortikosteroid-refraktärer/-abhängiger chronischer Graft-versus-Host-Erkrankung: eine einarmige, multizentrische, offene Phase-2-Studie",
      "title_en": "Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial",
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      "journal": "Frontiers in Immunology",
      "authors": "Qian et al.",
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      "doi": "10.3389/fimmu.2020.598359",
      "doi_url": "https://doi.org/10.3389/fimmu.2020.598359",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33324415/",
      "url": "https://h2medizin.org/studien/studie-qian-2020-chronische-graft-versus-host-erkrankung-phase-2/",
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    {
      "pmid": "33380580",
      "year": 2020,
      "title": "Zwei Wochen Wasserstoff-Inhalation können die Alterung des adaptiven und angeborenen Immunsystems bei Patienten mit fortgeschrittenem nicht-kleinzelligem Lungenkrebs deutlich umkehren: eine selbstkontrollierte Studie",
      "title_en": "Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study",
      "title_de": null,
      "journal": "Medical Gas Research",
      "authors": "Chen et al.",
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      "doi": "10.4103/2045-9912.304221",
      "doi_url": "https://doi.org/10.4103/2045-9912.304221",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33380580/",
      "url": "https://h2medizin.org/studien/studie-chen-2020-inhalation-immun-alterung-lungenkrebs/",
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    {
      "pmid": "33419292",
      "year": 2020,
      "title": "Antioxidative Aktivität einer Wasserstoffwasser-Maskenpackung aus gelartiger Emulsion und wasserstofferzeugendem Pulver",
      "title_en": "Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder.",
      "title_de": null,
      "journal": "International journal of molecular sciences",
      "authors": "Kwon et al.",
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      "doi": "10.3390/ijms21249731",
      "doi_url": "https://doi.org/10.3390/ijms21249731",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33419292/",
      "url": "https://h2medizin.org/studien/studie-kwon-2020-antioxidative-aktivitaet-wasserstoffwasser-maskenpackung/",
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      "human": false,
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    },
    {
      "pmid": "33004708",
      "year": 2020,
      "title": "Wirkungen von wasserstoffreichem Wasser, hergestellt durch Wechselstrom-Elektrolyse, auf die antioxidative Aktivität, DNA-oxidative Schäden und diabetesbezogene Marker.",
      "title_en": "Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers.",
      "title_de": null,
      "journal": "Medical gas research",
      "authors": "Asada et al.",
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      "doi": "10.4103/2045-9912.296041",
      "doi_url": "https://doi.org/10.4103/2045-9912.296041",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33004708/",
      "url": "https://h2medizin.org/studien/studie-asada-2020-wasserstoffreichem-hergestellt-wechselstrom-elektrolyse/",
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    },
    {
      "pmid": "33004705",
      "year": 2020,
      "title": "Inhalation von molekularem Wasserstoff erhöht die Aceton-Ausscheidung in der Atemluft bei submaximaler Belastung: eine randomisierte, einfachblinde, placebokontrollierte Studie.",
      "title_en": "Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study.",
      "title_de": null,
      "journal": "Medical gas research",
      "authors": "Hori et al.",
      "author_search": "hori hori",
      "doi": "10.4103/2045-9912.296038",
      "doi_url": "https://doi.org/10.4103/2045-9912.296038",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/33004705/",
      "url": "https://h2medizin.org/studien/studie-hori-2020-inhalation-erhoeht-aceton-ausscheidung/",
      "methods": [
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    },
    {
      "pmid": "32865158",
      "year": 2020,
      "title": "COVID-19 und Inhalation von molekularem Wasserstoff",
      "title_en": "COVID-19 and molecular hydrogen inhalation.",
      "title_de": null,
      "journal": "Therapeutic advances in respiratory disease",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1177/1753466620951051",
      "doi_url": "https://doi.org/10.1177/1753466620951051",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32865158/",
      "url": "https://h2medizin.org/studien/studie-ostojic-2020-covid-inhalation/",
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    },
    {
      "pmid": "32739699",
      "year": 2020,
      "title": "Bioelektrochemische CSB-Entfernung für eine energieeffiziente, maximale und robuste Stickstoffrückgewinnung aus Urin durch membranbelüftete Nitrifikation",
      "title_en": "Bio-electrochemical COD removal for energy-efficient, maximum and robust nitrogen recovery from urine through membrane aerated nitrification.",
      "title_de": null,
      "journal": "Water research",
      "authors": "De Paepe et al.",
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      "doi": "10.1016/j.watres.2020.116223",
      "doi_url": "https://doi.org/10.1016/j.watres.2020.116223",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32739699/",
      "url": "https://h2medizin.org/studien/studie-depaepe-2020-bioelektrochemische-csb-entfernung-energieeffiziente/",
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    },
    {
      "pmid": "32710259",
      "year": 2020,
      "title": "Wasserstoffbegastes Platin-Kolloid unterdrückt menschliche Speiseröhren- oder Zungenkarzinomzellen bei intrazellulärer Platin-Aufnahme und verminderter Sterblichkeit normaler Zellen",
      "title_en": "Hydrogen-bubbled platinum-colloid suppresses human esophagus- or tongue-carcinoma cells with intracellular platinum-uptake and the diminished normal-cell mortality.",
      "title_de": null,
      "journal": "Human cell",
      "authors": "Kato et al.",
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      "doi": "10.1007/s13577-020-00402-1",
      "doi_url": "https://doi.org/10.1007/s13577-020-00402-1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32710259/",
      "url": "https://h2medizin.org/studien/studie-kato-2020-wasserstoffbegastes-platin-kolloid-unterdrueckt/",
      "methods": [
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    },
    {
      "pmid": "32553919",
      "year": 2020,
      "title": "Eine schlanke Magnesium-Zink-Calcium-Legierung ZX00 zur Stabilisierung von Knochenbrüchen in einem großen, wachsenden Tiermodell",
      "title_en": "A lean magnesium-zinc-calcium alloy ZX00 used for bone fracture stabilization in a large growing-animal model.",
      "title_de": null,
      "journal": "Acta biomaterialia",
      "authors": "Holweg et al.",
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      "doi": "10.1016/j.actbio.2020.06.013",
      "doi_url": "https://doi.org/10.1016/j.actbio.2020.06.013",
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      "url": "https://h2medizin.org/studien/studie-holweg-2020-schlanke-magnesium-zink-calcium/",
      "methods": [
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    },
    {
      "pmid": "32541132",
      "year": 2020,
      "title": "Die Wasserstofftherapie kann zur Kontrolle des Tumorfortschritts und zur Linderung unerwünschter Wirkungen von Medikamenten bei Patienten mit fortgeschrittenem nicht-kleinzelligem Lungenkarzinom eingesetzt werden.",
      "title_en": "Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer.",
      "title_de": null,
      "journal": "Medical gas research",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.4103/2045-9912.285560",
      "doi_url": "https://doi.org/10.4103/2045-9912.285560",
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      "url": "https://h2medizin.org/studien/studie-chen-2020-wasserstofftherapie-kann-zur-kontrolle/",
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    },
    {
      "pmid": "32505097",
      "year": 2020,
      "title": "Interaktion verschiedener Zelltypen mit durch plasmaelektrolytische Oxidation modifiziertem Magnesium",
      "title_en": "Interaction of different cell types with magnesium modified by plasma electrolytic oxidation.",
      "title_de": null,
      "journal": "Colloids and surfaces. B, Biointerfaces",
      "authors": "Echeverry-Rendon et al.",
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      "doi": "10.1016/j.colsurfb.2020.111153",
      "doi_url": "https://doi.org/10.1016/j.colsurfb.2020.111153",
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      "url": "https://h2medizin.org/studien/studie-echeverryrendon-2020-interaktion-verschiedener-zelltypen-plasmaelektrolytische/",
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    },
    {
      "pmid": "32479062",
      "year": 2020,
      "title": "Photoaktivierter H₂-Nanogenerator für eine verbesserte Chemotherapie des Blasenkarzinoms",
      "title_en": "Photoactivated H2 Nanogenerator for Enhanced Chemotherapy of Bladder Cancer.",
      "title_de": null,
      "journal": "ACS nano",
      "authors": "Sun et al.",
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      "doi": "10.1021/acsnano.0c01300",
      "doi_url": "https://doi.org/10.1021/acsnano.0c01300",
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      "url": "https://h2medizin.org/studien/studie-sun-2020-photoaktivierter-nanogenerator-verbesserte-chemotherapie/",
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    },
    {
      "pmid": "32407476",
      "year": 2020,
      "title": "Inhalation von Wasserstoffgas (XEN) verbessert die Atemwegsentzündung bei Asthma- und COPD-Patienten.",
      "title_en": "Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.",
      "title_de": null,
      "journal": "QJM : monthly journal of the Association of Physicians",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1093/qjmed/hcaa164",
      "doi_url": "https://doi.org/10.1093/qjmed/hcaa164",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32407476/",
      "url": "https://h2medizin.org/studien/studie-wang-2020-inhalation-wasserstoffgas-xen-verbessert/",
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    {
      "pmid": "32399209",
      "year": 2020,
      "title": "Fallbericht: Akute Hydrotherapie mit übersättigtem wasserstoffreichem Wasser bei einer Knöchelverstauchung eines professionellen Athleten.",
      "title_en": "Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete.",
      "title_de": null,
      "journal": "F1000Research",
      "authors": "Javorac et al.",
      "author_search": "javorac javorac",
      "doi": "10.12688/f1000research.22850.1",
      "doi_url": "https://doi.org/10.12688/f1000research.22850.1",
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      "url": "https://h2medizin.org/studien/studie-javorac-2020-fallbericht-akute-hydrotherapie-uebersaettigtem/",
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    {
      "pmid": "32380825",
      "year": 2020,
      "title": "NIR-getriebene Nanoplattform zur H₂-Produktion durch Wasserspaltung für eine H₂-vermittelte, kaskadenverstärkende synergistische Krebstherapie",
      "title_en": "NIR-Driven Water Splitting H2 Production Nanoplatform for H2-Mediated Cascade-Amplifying Synergetic Cancer Therapy.",
      "title_de": null,
      "journal": "ACS applied materials & interfaces",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1021/acsami.0c03852",
      "doi_url": "https://doi.org/10.1021/acsami.0c03852",
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    },
    {
      "pmid": "32376537",
      "year": 2020,
      "title": "Wasserstoffwasser lindert Paraquat-induzierte Schäden an Lungenfibroblasten in vitro durch Verstärkung der Nrf2-Expression",
      "title_en": "[Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression].",
      "title_de": null,
      "journal": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.12122/j.issn.1673-4254.2020.02.15",
      "doi_url": "https://doi.org/10.12122/j.issn.1673-4254.2020.02.15",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32376537/",
      "url": "https://h2medizin.org/studien/studie-li-2020-wasserstoffwasser-lindert-paraquat-induzierte/",
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    },
    {
      "pmid": "32314789",
      "year": 2020,
      "title": "Wasserstoffgas unterdrückt den Verlauf von Lungenkrebs durch Herunterregulierung von CD47",
      "title_en": "Hydrogen gas represses the progression of lung cancer via down-regulating CD47.",
      "title_de": null,
      "journal": "Bioscience reports",
      "authors": "Meng et al.",
      "author_search": "meng meng",
      "doi": "10.1042/bsr20192761",
      "doi_url": "https://doi.org/10.1042/bsr20192761",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32314789/",
      "url": "https://h2medizin.org/studien/studie-meng-2020-wasserstoffgas-unterdrueckt-den-verlauf/",
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    },
    {
      "pmid": "32302306",
      "year": 2020,
      "title": "Kontinuierliche Wasserstoffinhalation verhindert vaskuläres Remodeling durch Reduktion von oxidativem Stress",
      "title_en": "Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress.",
      "title_de": null,
      "journal": "PloS one",
      "authors": "Kiyoi et al.",
      "author_search": "kiyoi kiyoi",
      "doi": "10.1371/journal.pone.0227582",
      "doi_url": "https://doi.org/10.1371/journal.pone.0227582",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32302306/",
      "url": "https://h2medizin.org/studien/studie-kiyoi-2020-kontinuierliche-wasserstoffinhalation-verhindert-vaskulaeres/",
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    },
    {
      "pmid": "32278311",
      "year": 2020,
      "title": "Wirkung des Aggrecan-Abbaus auf die Nanomechanik von Hyaluronan in der extrafibrillären Matrix des Anulus fibrosus: Eine molekulardynamische Untersuchung.",
      "title_en": "Effect of aggrecan degradation on the nanomechanics of hyaluronan in extra-fibrillar matrix of annulus fibrosus: A molecular dynamics investigation.",
      "title_de": null,
      "journal": "Journal of the mechanical behavior of biomedical materials",
      "authors": "Bhattacharya et al.",
      "author_search": "bhattacharya bhattacharya",
      "doi": "10.1016/j.jmbbm.2020.103752",
      "doi_url": "https://doi.org/10.1016/j.jmbbm.2020.103752",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32278311/",
      "url": "https://h2medizin.org/studien/studie-bhattacharya-2020-des-aggrecan-abbaus-nanomechanik/",
      "methods": [
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    {
      "pmid": "32236175",
      "year": 2020,
      "title": "Wirkung thermischer Behandlungen auf die In-vitro-Stärkeverdaulichkeit von getrockneten Sorghum-Nudeln.",
      "title_en": "Effect of thermal treatments on in vitro starch digestibility of sorghum dried noodles.",
      "title_de": null,
      "journal": "Food & function",
      "authors": "Liu et al.",
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    {
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      "year": 2020,
      "title": "Wasserstoffreiches Wasser unterdrückt die durch 3 aufeinanderfolgende Tage schwerer körperlicher Belastung induzierte Senkung der gesamten antioxidativen Kapazität des Blutes bei körperlich aktiven Männern.",
      "title_en": "Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males.",
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    {
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      "year": 2020,
      "title": "Wasserstoff übt Neuroprotektion durch Aktivierung des miR-21/PI3K/AKT/GSK-3β-Signalwegs in einem In-vitro-Modell des Schädel-Hirn-Traumas aus.",
      "title_en": "Hydrogen exerts neuroprotection by activation of the miR-21/PI3K/AKT/GSK-3β pathway in an in vitro model of traumatic brain injury.",
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      "title": "Molekularer Wasserstoff mildert sepsisinduzierte Neuroinflammation durch Regulation der Mikroglia-Polarisierung über einen mTOR-Autophagie-abhängigen Signalweg.",
      "title_en": "Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.",
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    {
      "pmid": "32019803",
      "year": 2020,
      "title": "Syntrophie durch H₂-Transfer zwischen den Arten Christensenella und Methanobrevibacter liegt ihrem globalen gemeinsamen Vorkommen im menschlichen Darm zugrunde.",
      "title_en": "Syntrophy via Interspecies H2 Transfer between Christensenella and Methanobrevibacter Underlies Their Global Cooccurrence in the Human Gut.",
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    {
      "pmid": "31977289",
      "year": 2020,
      "title": "Kabellose weiche Robotik mit vollständig integrierten drahtlosen Sensor- und Aktuatorsystemen für somatosensorische und respiratorische Funktionen.",
      "title_en": "Untethered Soft Robotics with Fully Integrated Wireless Sensing and Actuating Systems for Somatosensory and Respiratory Functions.",
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      "title": "Molekularer Wasserstoff reguliert die PTEN-AKT-mTOR-Signalübertragung über ROS, um die mit der Peritonealdialyse verbundene peritoneale Fibrose zu lindern.",
      "title_en": "Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal dialysis-related peritoneal fibrosis.",
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      "authors": "Lu et al.",
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      "title": "Wasserstoff hemmt das Wachstum des Endometriumkarzinoms über einen ROS/NLRP3/Caspase-1/GSDMD-vermittelten pyroptotischen Signalweg.",
      "title_en": "Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.",
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      "journal": "BMC cancer",
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    {
      "pmid": "31810604",
      "year": 2020,
      "title": "Molekularer Wasserstoff unterdrückt die Superoxidbildung im mitochondrialen Komplex I und senkt das mitochondriale Membranpotenzial.",
      "title_en": "Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential.",
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      "url": "https://h2medizin.org/studien/studie-ishihara-2020-unterdrueckt-superoxidbildung-mitochondrialen-komplex/",
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    {
      "pmid": "31746358",
      "year": 2020,
      "title": "Schützende Wirkungen von wasserstoffreicher Kochsalzlösung gegen experimentelle diabetische periphere Neuropathie über die Aktivierung mitochondrialer ATP-sensitiver Kaliumkanäle bei Ratten.",
      "title_en": "Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats.",
      "title_de": null,
      "journal": "Molecular medicine reports",
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      "doi": "10.3892/mmr.2019.10795",
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    {
      "pmid": "32029879",
      "year": 2020,
      "title": "Wasserstoff dämpft allergische Entzündung durch Umkehr eines Umschaltens im Energiestoffwechsel",
      "title_en": "Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch",
      "title_de": null,
      "journal": "Scientific Reports",
      "authors": "Niu et al.",
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      "doi": "10.1038/s41598-020-58999-0",
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    {
      "pmid": "31267691",
      "year": 2019,
      "title": "Durch Mikro-/Nanomaterialien verstärkte Wasserstofftherapie",
      "title_en": "Micro/Nanomaterials-Augmented Hydrogen Therapy",
      "title_de": null,
      "journal": "Advanced Healthcare Materials",
      "authors": "Zhou et al.",
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      "doi": "10.1002/adhm.201900463",
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    {
      "pmid": "31871547",
      "year": 2019,
      "title": "Medizinische Anwendung von Wasserstoff bei hämatologischen Erkrankungen.",
      "title_en": "Medical Application of Hydrogen in Hematological Diseases.",
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      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Qian et al.",
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      "doi": "10.1155/2019/3917393",
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    {
      "pmid": "31509764",
      "year": 2019,
      "title": "Myalgische Enzephalomyelitis/chronisches Erschöpfungssyndrom: Von pathophysiologischen Erkenntnissen zu neuartigen therapeutischen Möglichkeiten.",
      "title_en": "Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities.",
      "title_de": null,
      "journal": "Pharmacological research",
      "authors": "Morris et al.",
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    {
      "pmid": "31159153",
      "year": 2019,
      "title": "Ein neuer Ansatz zur Prävention und Behandlung kardiovaskulärer Erkrankungen. Molekularer Wasserstoff reduziert die Auswirkungen von oxidativem Stress signifikant.",
      "title_en": "A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.",
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      "doi": "10.3390/molecules24112076",
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    {
      "pmid": "31100203",
      "year": 2019,
      "title": "Zirkulierender Botenstoff für die durch molekularen Wasserstoff induzierte Neuroprotektion.",
      "title_en": "Circulating messenger for neuroprotection induced by molecular hydrogen.",
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      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "Noda et al.",
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    {
      "pmid": "31057105",
      "year": 2019,
      "title": "Therapeutische Wirksamkeit von molekularem Wasserstoff: Ein neuer mechanistischer Einblick.",
      "title_en": "Therapeutic Efficacy of Molecular Hydrogen: A New Mechanistic Insight.",
      "title_de": null,
      "journal": "Current pharmaceutical design",
      "authors": "Ishibashi",
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      "doi": "10.2174/1381612825666190506123038",
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    {
      "pmid": "30970215",
      "year": 2019,
      "title": "Wasserstoffgas: von der klinischen Medizin zu einem aufkommenden ergogenen Molekül für Sportler.",
      "title_en": "Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes 1.",
      "title_de": null,
      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "LeBaron et al.",
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      "doi": "10.1139/cjpp-2019-0067",
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    {
      "pmid": "30773939",
      "year": 2019,
      "title": "Die präventiven und therapeutischen Wirkungen von molekularem Wasserstoff bei Augenerkrankungen und -verletzungen, an denen oxidativer Stress beteiligt ist.",
      "title_en": "The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved.",
      "title_de": null,
      "journal": "Free radical research",
      "authors": "Cejka et al.",
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      "doi": "10.1080/10715762.2019.1582770",
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    {
      "pmid": "30543459",
      "year": 2019,
      "title": "Molekularer Wasserstoff: Potenzial zur Minderung von durch oxidativen Stress induzierten Strahlenschäden.",
      "title_en": "Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury 1.",
      "title_de": null,
      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "Kura et al.",
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      "doi": "10.1139/cjpp-2018-0604",
      "doi_url": "https://doi.org/10.1139/cjpp-2018-0604",
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      "url": "https://h2medizin.org/studien/studie-kura-2019-potenzial-zur-minderung-oxidativen/",
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    {
      "pmid": "30529801",
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      "title": "Wasserstoff als komplementäre Therapie gegen den ischämischen Schlaganfall: Eine Übersicht über die Evidenz.",
      "title_en": "Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence.",
      "title_de": null,
      "journal": "Journal of the neurological sciences",
      "authors": "Li et al.",
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      "doi": "10.1016/j.jns.2018.11.004",
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      "url": "https://h2medizin.org/studien/studie-li-2019-komplementaere-gegen-den-ischaemischen/",
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    {
      "pmid": "29681183",
      "year": 2019,
      "title": "Neonatale hypoxisch-ischämische Enzephalopathie: aufkommende therapeutische Strategien auf Basis der pathophysiologischen Phasen der Schädigung.",
      "title_en": "Neonatal hypoxic-ischemic encephalopathy: emerging therapeutic strategies based on pathophysiologic phases of the injury.",
      "title_de": null,
      "journal": "The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians",
      "authors": "Wang et al.",
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      "doi": "10.1080/14767058.2018.1468881",
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      "url": "https://h2medizin.org/studien/studie-wang-2019-neonatale-hypoxisch-ischaemische-enzephalopathie/",
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    },
    {
      "pmid": "31251888",
      "year": 2019,
      "title": "Trinken von Wasserstoffwasser steigert die Ausdauer und lindert psychometrische Ermüdung: eine randomisierte, doppelblinde, placebo-kontrollierte Studie",
      "title_en": "Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study",
      "title_de": null,
      "journal": "Canadian Journal of Physiology and Pharmacology",
      "authors": "Mikami et al.",
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      "doi": "10.1139/cjpp-2019-0059",
      "doi_url": "https://doi.org/10.1139/cjpp-2019-0059",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31251888/",
      "url": "https://h2medizin.org/studien/studie-mikami-2019-ausdauer-psychometrische-ermuedung/",
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      "human": true,
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    },
    {
      "pmid": "31574544",
      "year": 2019,
      "title": "Wasserstoffreiches Wasser verbesserte ventilatorische, perzeptuelle und Laktat-Reaktionen auf Belastung",
      "title_en": "Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise",
      "title_de": null,
      "journal": "International Journal of Sports Medicine",
      "authors": "Botek et al.",
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      "doi": "10.1055/a-0991-0268",
      "doi_url": "https://doi.org/10.1055/a-0991-0268",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31574544/",
      "url": "https://h2medizin.org/studien/studie-botek-2019-ventilatorische-laktat-reaktionen-belastung/",
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    },
    {
      "pmid": "30982748",
      "year": 2019,
      "title": "Wasserstoffreiches Wasser reduziert die Fettansammlung in der Leber und verbessert die Leberenzymprofile bei Patienten mit nicht-alkoholischer Fettlebererkrankung: eine randomisierte kontrollierte Pilotstudie.",
      "title_en": "Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.",
      "title_de": null,
      "journal": "Clinics and research in hepatology and gastroenterology",
      "authors": "Korovljev et al.",
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      "doi": "10.1016/j.clinre.2019.03.008",
      "doi_url": "https://doi.org/10.1016/j.clinre.2019.03.008",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30982748/",
      "url": "https://h2medizin.org/studien/studie-korovljev-2019-reduziert-fettansammlung-leber-verbessert/",
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    },
    {
      "pmid": "30542740",
      "year": 2019,
      "title": "Wasserstoffgas stellt erschöpfte CD8+-T-Zellen bei Patienten mit fortgeschrittenem kolorektalem Karzinom wieder her und verbessert so die Prognose.",
      "title_en": "Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis.",
      "title_de": null,
      "journal": "Oncology reports",
      "authors": "Akagi et al.",
      "author_search": "akagi akagi",
      "doi": "10.3892/or.2018.6841",
      "doi_url": "https://doi.org/10.3892/or.2018.6841",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30542740/",
      "url": "https://h2medizin.org/studien/studie-akagi-2019-wasserstoffgas-stellt-erschoepfte-cd8/",
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      ],
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      "human": true,
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    },
    {
      "pmid": "32595937",
      "year": 2019,
      "title": "Fallbericht: Bukkale Verabreichung einer wasserstoffproduzierenden Mischung nach einem leichten Schädel-Hirn-Trauma bei einem professionellen Athleten.",
      "title_en": "Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.",
      "title_de": null,
      "journal": "F1000Research",
      "authors": "Javorac et al.",
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      "doi": "10.12688/f1000research.19739.1",
      "doi_url": "https://doi.org/10.12688/f1000research.19739.1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32595937/",
      "url": "https://h2medizin.org/studien/studie-javorac-2019-fallbericht-bukkale-verabreichung-wasserstoffproduzierenden/",
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        "fundamentals-safety"
      ],
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      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "32255077",
      "year": 2019,
      "title": "Säureempfindliche, H₂-freisetzende Fe-Nanopartikel für eine sichere und wirksame Krebstherapie.",
      "title_en": "Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy.",
      "title_de": null,
      "journal": "Journal of materials chemistry. B",
      "authors": "Kou et al.",
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      "doi": "10.1039/c9tb00338j",
      "doi_url": "https://doi.org/10.1039/c9tb00338j",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/32255077/",
      "url": "https://h2medizin.org/studien/studie-kou-2019-saeureempfindliche-freisetzende-nanopartikel-sichere/",
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      "human": false,
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    },
    {
      "pmid": "31768722",
      "year": 2019,
      "title": "Wirkung von wasserstoffreichem Wasser auf den Nrf2/ARE-Signalweg bei Ratten mit myokardialem Ischämie-Reperfusionsschaden.",
      "title_en": "Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.",
      "title_de": null,
      "journal": "Journal of bioenergetics and biomembranes",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1007/s10863-019-09814-7",
      "doi_url": "https://doi.org/10.1007/s10863-019-09814-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31768722/",
      "url": "https://h2medizin.org/studien/studie-li-2019-wasserstoffreichem-den-nrf2-signalweg/",
      "methods": [
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      ],
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      "human": false,
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    },
    {
      "pmid": "31738389",
      "year": 2019,
      "title": "Molekularer Wasserstoff: aktueller Kenntnisstand zum Mechanismus bei der Linderung von Schäden durch freie Radikale und von Erkrankungen.",
      "title_en": "Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases.",
      "title_de": null,
      "journal": "Acta biochimica et biophysica Sinica",
      "authors": "Tao et al.",
      "author_search": "tao tao",
      "doi": "10.1093/abbs/gmz121",
      "doi_url": "https://doi.org/10.1093/abbs/gmz121",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31738389/",
      "url": "https://h2medizin.org/studien/studie-tao-2019-aktueller-kenntnisstand-zum-mechanismus/",
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        "oxidative-stress"
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      "evidence_level": 4,
      "human": false,
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      "h2category": "review"
    },
    {
      "pmid": "31737671",
      "year": 2019,
      "title": "Die Inhalation von Wasserstoff verbessert frühe EEG-Charakteristika nach der Reanimation in einem Modell des asphyktischen Herzstillstands bei Ratten.",
      "title_en": "Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac Arrest Rat Model.",
      "title_de": null,
      "journal": "BioMed research international",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1155/2019/6410159",
      "doi_url": "https://doi.org/10.1155/2019/6410159",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31737671/",
      "url": "https://h2medizin.org/studien/studie-chen-2019-inhalation-verbessert-fruehe-eeg/",
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    },
    {
      "pmid": "31622584",
      "year": 2019,
      "title": "Staphylococcus-aureus-Evasionsproteine EapH1 und EapH2: Untersuchung eines alternativen Bindungsmotivs für die humane neutrophile Elastase auf Residuenebene",
      "title_en": "Staphylococcus aureus evasion proteins EapH1 and EapH2: Residue-level investigation of an alternative binding motif for human neutrophil elastase.",
      "title_de": null,
      "journal": "Archives of biochemistry and biophysics",
      "authors": "Herdendorf et al.",
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      "doi": "10.1016/j.abb.2019.108140",
      "doi_url": "https://doi.org/10.1016/j.abb.2019.108140",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31622584/",
      "url": "https://h2medizin.org/studien/studie-herdendorf-2019-staphylococcus-aureus-evasionsproteine-eaph1/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
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    },
    {
      "pmid": "31600256",
      "year": 2019,
      "title": "Positive Wirkung von elektrolysiertem reduziertem Wasser auf die Darmpermeabilität, die fäkale Mikrobiota und die Leber in einem Tiermodell der Parkinson-Krankheit",
      "title_en": "Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson's disease.",
      "title_de": null,
      "journal": "PloS one",
      "authors": "Bordoni et al.",
      "author_search": "bordoni bordoni",
      "doi": "10.1371/journal.pone.0223238",
      "doi_url": "https://doi.org/10.1371/journal.pone.0223238",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31600256/",
      "url": "https://h2medizin.org/studien/studie-bordoni-2019-positive-elektrolysiertem-reduziertem-darmpermeabilitaet/",
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    },
    {
      "pmid": "31574947",
      "year": 2019,
      "title": "In-vivo-Simulation der Magnesium-Abbaubarkeit mithilfe eines neuen strömungsdynamischen Prüfstandsansatzes",
      "title_en": "In Vivo Simulation of Magnesium Degradability Using a New Fluid Dynamic Bench Testing Approach.",
      "title_de": null,
      "journal": "International journal of molecular sciences",
      "authors": "Jung et al.",
      "author_search": "jung jung",
      "doi": "10.3390/ijms20194859",
      "doi_url": "https://doi.org/10.3390/ijms20194859",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31574947/",
      "url": "https://h2medizin.org/studien/studie-jung-2019-vivo-simulation-magnesium-abbaubarkeit/",
      "methods": [
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    },
    {
      "pmid": "31574107",
      "year": 2019,
      "title": "Eine Organkonservierungslösung mit gelöstem Wasserstoffgas aus einem wasserstoffabsorbierenden Legierungsbehälter verbessert die Funktion transplantierter ischämischer Nieren bei Miniaturschweinen",
      "title_en": "Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs.",
      "title_de": null,
      "journal": "PloS one",
      "authors": "Kobayashi et al.",
      "author_search": "kobayashi kobayashi",
      "doi": "10.1371/journal.pone.0222863",
      "doi_url": "https://doi.org/10.1371/journal.pone.0222863",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31574107/",
      "url": "https://h2medizin.org/studien/studie-kobayashi-2019-organkonservierungsloesung-geloestem-wasserstoffgas-aus/",
      "methods": [
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    },
    {
      "pmid": "31552873",
      "year": 2019,
      "title": "„Real-World-Erhebung“ zur wasserstoffgesteuerten Krebsbehandlung: ein Folgebericht über 82 Patienten mit fortgeschrittenem Krebs.",
      "title_en": "\"Real world survey\" of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients.",
      "title_de": null,
      "journal": "Medical gas research",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.4103/2045-9912.266985",
      "doi_url": "https://doi.org/10.4103/2045-9912.266985",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31552873/",
      "url": "https://h2medizin.org/studien/studie-chen-2019-real-world-erhebung-zur/",
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      "evidence_level": 2,
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    },
    {
      "pmid": "31499254",
      "year": 2019,
      "title": "Wasserstoffgas verbessert die photothermische Therapie von Tumoren und hemmt das Wiederauftreten ruhender Ferntumoren",
      "title_en": "Hydrogen gas improves photothermal therapy of tumor and restrains the relapse of distant dormant tumor.",
      "title_de": null,
      "journal": "Biomaterials",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1016/j.biomaterials.2019.119472",
      "doi_url": "https://doi.org/10.1016/j.biomaterials.2019.119472",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31499254/",
      "url": "https://h2medizin.org/studien/studie-zhang-2019-wasserstoffgas-verbessert-photothermische-tumoren/",
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    },
    {
      "pmid": "31479580",
      "year": 2019,
      "title": "Lebensdauer von Parawasserstoff in wässrigen Lösungen und menschlichem Blut",
      "title_en": "Lifetime of Parahydrogen in Aqueous Solutions and Human Blood.",
      "title_de": null,
      "journal": "Chemphyschem : a European journal of chemical physics and physical chemistry",
      "authors": "Schmidt et al.",
      "author_search": "schmidt schmidt",
      "doi": "10.1002/cphc.201900670",
      "doi_url": "https://doi.org/10.1002/cphc.201900670",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31479580/",
      "url": "https://h2medizin.org/studien/studie-schmidt-2019-lebensdauer-parawasserstoff-waessrigen-loesungen/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
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    },
    {
      "pmid": "31352109",
      "year": 2019,
      "title": "Wirkung physikalischer Reize von verändertem Extraktmedium aus biologisch abbaubaren Magnesiumimplantaten auf menschliche Gingivafibroblasten",
      "title_en": "Effect of physical cues of altered extract media from biodegradable magnesium implants on human gingival fibroblasts.",
      "title_de": null,
      "journal": "Acta biomaterialia",
      "authors": "Amberg et al.",
      "author_search": "amberg amberg",
      "doi": "10.1016/j.actbio.2019.07.022",
      "doi_url": "https://doi.org/10.1016/j.actbio.2019.07.022",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31352109/",
      "url": "https://h2medizin.org/studien/studie-amberg-2019-physikalischer-reize-veraendertem-extraktmedium/",
      "methods": [
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      "human": false,
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    },
    {
      "pmid": "31329427",
      "year": 2019,
      "title": "Wasserstoffgas: Von der Entzündungsbehandlung zur Krebstherapie",
      "title_en": "Hydrogen Gas from Inflammation Treatment to Cancer Therapy.",
      "title_de": null,
      "journal": "ACS nano",
      "authors": "Wu et al.",
      "author_search": "wu wu",
      "doi": "10.1021/acsnano.9b05124",
      "doi_url": "https://doi.org/10.1021/acsnano.9b05124",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31329427/",
      "url": "https://h2medizin.org/studien/studie-wu-2019-wasserstoffgas-entzuendungsbehandlung-zur-krebstherapie/",
      "methods": [
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      "human": false,
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      "h2category": "review"
    },
    {
      "pmid": "31323168",
      "year": 2019,
      "title": "Mit bedingt pathogenen Stämmen infizierte Hautgeschwüre, behandelt mit lokaler Wasserstoffwasser-Auflage bei zwei Patienten mit Pemphigus vulgaris: Fallberichte mit zweimonatiger Nachbeobachtung.",
      "title_en": "Skin ulcers infected with conditional pathogenic strains treated with local hydrogen water packing in two pemphigus vulgaris patients: Case reports with follow-up for 2 months.",
      "title_de": null,
      "journal": "Dermatologic therapy",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.1111/dth.13027",
      "doi_url": "https://doi.org/10.1111/dth.13027",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31323168/",
      "url": "https://h2medizin.org/studien/studie-yang-2019-bedingt-pathogenen-staemmen-infizierte/",
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    {
      "pmid": "31295412",
      "year": 2019,
      "title": "Molekularer Wasserstoff unterdrückt den durch freie Radikale induzierten Zelltod durch Minderung der Fettsäure-Peroxidation und der mitochondrialen Dysfunktion",
      "title_en": "Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction.",
      "title_de": null,
      "journal": "Canadian journal of physiology and pharmacology",
      "authors": "Iuchi et al.",
      "author_search": "iuchi iuchi",
      "doi": "10.1139/cjpp-2018-0741",
      "doi_url": "https://doi.org/10.1139/cjpp-2018-0741",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31295412/",
      "url": "https://h2medizin.org/studien/studie-iuchi-2019-unterdrueckt-den-freie-radikale/",
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      "human": false,
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    },
    {
      "pmid": "31249254",
      "year": 2019,
      "title": "Wirkungen eines Bades in wasserstoffreichem Wasser auf das viszerale Fett und Hautflecken, mit kochbeständigen Wasserstoffbläschen.",
      "title_en": "Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles.",
      "title_de": null,
      "journal": "Medical gas research",
      "authors": "Asada et al.",
      "author_search": "asada asada",
      "doi": "10.4103/2045-9912.260647",
      "doi_url": "https://doi.org/10.4103/2045-9912.260647",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31249254/",
      "url": "https://h2medizin.org/studien/studie-asada-2019-bades-wasserstoffreichem-viszerale-fett/",
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    },
    {
      "pmid": "31162794",
      "year": 2019,
      "title": "Energiekonservierung im Darmmikroben Methanomassiliicoccus luminyensis beruht auf membrangebundener Ferredoxin-Oxidation gekoppelt an Heterodisulfid-Reduktion",
      "title_en": "Energy conservation in the gut microbe Methanomassiliicoccus luminyensis is based on membrane-bound ferredoxin oxidation coupled to heterodisulfide reduction.",
      "title_de": null,
      "journal": "The FEBS journal",
      "authors": "Kröninger et al.",
      "author_search": "kröninger kröninger",
      "doi": "10.1111/febs.14948",
      "doi_url": "https://doi.org/10.1111/febs.14948",
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      "url": "https://h2medizin.org/studien/studie-kroeninger-2019-energiekonservierung-darmmikroben-methanomassiliicoccus-luminyensis/",
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    {
      "pmid": "31151236",
      "year": 2019,
      "title": "Unterschiedliche molekulare Wechselwirkung zwischen Kollagen und α- bzw. β-Chitin in mechanisch verbessertem elektrogesponnenem Komposit",
      "title_en": "Different Molecular Interaction between Collagen and α- or β-Chitin in Mechanically Improved Electrospun Composite.",
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    {
      "pmid": "31113492",
      "year": 2019,
      "title": "Molekularer Wasserstoff unterdrückt das Glioblastom-Wachstum durch Induktion der Differenzierung gliomstammzellähnlicher Zellen",
      "title_en": "Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation.",
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      "journal": "Stem cell research & therapy",
      "authors": "Liu et al.",
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      "doi": "10.1186/s13287-019-1241-x",
      "doi_url": "https://doi.org/10.1186/s13287-019-1241-x",
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      "url": "https://h2medizin.org/studien/studie-liu-2019-unterdrueckt-glioblastom-wachstum-induktion/",
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    {
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      "year": 2019,
      "title": "Wasserstoffgas schützt vor ovariektomie-induzierter Osteoporose durch Hemmung der NF-κB-Aktivierung.",
      "title_en": "Hydrogen gas protects against ovariectomy-induced osteoporosis by inhibiting NF-κB activation.",
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      "authors": "Wu et al.",
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      "url": "https://h2medizin.org/studien/studie-wu-2019-wasserstoffgas-schuetzt-vor-ovariektomie/",
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    {
      "pmid": "31013316",
      "year": 2019,
      "title": "Wirkungen von wasserstoffreichem Wasser in einem Rattenmodell der polyzystischen Nierenerkrankung.",
      "title_en": "Effects of hydrogen-rich water in a rat model of polycystic kidney disease.",
      "title_de": null,
      "journal": "PloS one",
      "authors": "Yamasaki et al.",
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      "doi": "10.1371/journal.pone.0215766",
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    {
      "pmid": "30968583",
      "year": 2019,
      "title": "Säureempfindliches H₂-freisetzendes 2D-MgB₂-Nanoblatt für therapeutische Synergie und Abschwächung von Nebenwirkungen der Magenkrebs-Chemotherapie.",
      "title_en": "Acid-Responsive H2 -Releasing 2D MgB2 Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy.",
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      "journal": "Advanced healthcare materials",
      "authors": "Fan et al.",
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    {
      "pmid": "30877875",
      "year": 2019,
      "title": "Wasserstoffgas-Inhalation mildert die sepsis-induzierte Leberschädigung in FUNDC1-abhängiger Weise.",
      "title_en": "Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner.",
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      "journal": "International immunopharmacology",
      "authors": "Yan et al.",
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    {
      "pmid": "30858437",
      "year": 2019,
      "title": "Wasserstoff-Beatmung kombiniert mit milder Hypothermie verbessert kurzfristige neurologische Ergebnisse in einem 5-Tage-Ferkelmodell der neonatalen Hypoxie-Ischämie.",
      "title_en": "Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.",
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      "journal": "Scientific reports",
      "authors": "Htun et al.",
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    {
      "pmid": "30853611",
      "year": 2019,
      "title": "In-vitro- und In-vivo-Studien zu Mg-30Sc-Legierungen mit unterschiedlicher Phasenstruktur für die mögliche Anwendung im Knochen.",
      "title_en": "In vitro and in vivo studies of Mg-30Sc alloys with different phase structure for potential usage within bone.",
      "title_de": null,
      "journal": "Acta biomaterialia",
      "authors": "Liu et al.",
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      "pmid": "30825755",
      "year": 2019,
      "title": "Hyperoxygenierte wasserstoffreiche Lösung unterdrückt die durch hämorrhagischen Schock induzierte Lungenschädigung bei Ratten.",
      "title_en": "Hyperoxygenated Hydrogen-Rich Solution Suppresses Lung Injury Induced by Hemorrhagic Shock in Rats.",
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      "journal": "The Journal of surgical research",
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    {
      "pmid": "30693753",
      "year": 2019,
      "title": "Mechanische Festigkeit, Bioabbaubarkeit sowie In-vitro- und In-vivo-Biokompatibilität von Zn-Biomaterialien.",
      "title_en": "Mechanical Strength, Biodegradation, and in Vitro and in Vivo Biocompatibility of Zn Biomaterials.",
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      "journal": "ACS applied materials & interfaces",
      "authors": "Zhu et al.",
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      "title": "Wasserstoffgas reduziert die HMGB1-Freisetzung im Lungengewebe septischer Mäuse über einen Nrf2/HO-1-abhängigen Signalweg.",
      "title_en": "Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.",
      "title_de": null,
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      "year": 2019,
      "title": "Wasserstoffgas reduziert die durch chronische intermittierende Hypoxie induzierte Hypertonie durch Hemmung der sympathischen Nervenaktivität und Steigerung vasodilatatorischer Reaktionen über die Antioxidation.",
      "title_en": "Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation.",
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    {
      "pmid": "30367274",
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      "title": "Jüngste Fortschritte bei der Elektrooxidation von Harnstoff für die Direkt-Harnstoff-Brennstoffzelle und die Harnstoff-Elektrolyse.",
      "title_en": "Recent Advances in the Electro-Oxidation of Urea for Direct Urea Fuel Cell and Urea Electrolysis.",
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      "journal": "Topics in current chemistry (Cham)",
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    {
      "pmid": "30107657",
      "year": 2018,
      "title": "Forschungsfortschritt zu wasserstoffreicher Kochsalzlösung bei Augenerkrankungen.",
      "title_en": "[Research progress of hydrogen-rich saline for eye diseases].",
      "title_de": null,
      "journal": "[Zhonghua yan ke za zhi] Chinese journal of ophthalmology",
      "authors": "Chen et al.",
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      "doi": "10.3760/cma.j.issn.0412-4081.2018.08.015",
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    {
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      "title": "Wasserstofftherapie bei kardiovaskulären und metabolischen Erkrankungen: vom Labor zum Krankenbett",
      "title_en": "Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside.",
      "title_de": null,
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      "authors": "Zhang et al.",
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    {
      "pmid": "29759891",
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      "title": "Die mutmaßliche Rolle von oxidativem Stress und Entzündung in der Pathophysiologie von Schlafstörungen bei neuropsychiatrischen Erkrankungen",
      "title_en": "The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis.",
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    {
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      "title": "Metabolismus von Wasserstoffgasen und Gallensäuren im Darmmikrobiom",
      "title_en": "Metabolism of hydrogen gases and bile acids in the gut microbiome.",
      "title_de": null,
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    {
      "pmid": "30207619",
      "year": 2018,
      "title": "Randomisierte, doppelblinde, multizentrische Studie zu Wasserstoffwasser bei Morbus Parkinson",
      "title_en": "Randomized, double-blind, multicenter trial of hydrogen water for Parkinson's disease.",
      "title_de": null,
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      "authors": "Yoritaka et al.",
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      "pmid": "29798076",
      "year": 2018,
      "title": "Klinische Studie zu wasserstoffreicher Kochsalzlösung in der Behandlung von mittelschwerer bis schwerer allergischer Rhinitis",
      "title_en": "[Clinical study of hydrogen-rich saline in the treatment of moderate to severe allergic rhinitis].",
      "title_de": null,
      "journal": "Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery",
      "authors": "Jin et al.",
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      "doi": "10.13201/j.issn.1001-1781.2018.07.004",
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      "url": "https://h2medizin.org/studien/studie-jin-2018-klinische-wasserstoffreicher-kochsalzloesung-mittelschwerer/",
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    {
      "pmid": "29110615",
      "year": 2018,
      "title": "Wirkungen von molekularem Wasserstoff bei leichter kognitiver Beeinträchtigung, untersucht anhand eines Tiermodells und einer randomisierten klinischen Studie",
      "title_en": "Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment.",
      "title_de": null,
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      "authors": "Nishimaki et al.",
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      "doi": "10.2174/1567205014666171106145017",
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      "url": "https://h2medizin.org/studien/studie-nishimaki-2018-leichter-kognitiver-beeintraechtigung-untersucht/",
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    {
      "pmid": "28560519",
      "year": 2018,
      "title": "Molekularer Wasserstoff beeinflusst Körperzusammensetzung, Stoffwechselprofile und mitochondriale Funktion bei übergewichtigen Frauen mittleren Alters",
      "title_en": "Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women.",
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      "journal": "Irish journal of medical science",
      "authors": "Korovljev et al.",
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      "doi": "10.1007/s11845-017-1638-4",
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      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28560519/",
      "url": "https://h2medizin.org/studien/studie-korovljev-2018-beeinflusst-koerperzusammensetzung-stoffwechselprofile-mitochondriale/",
      "methods": [
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      "human": true,
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    },
    {
      "pmid": "30586410",
      "year": 2018,
      "title": "Quantifizierung der Wasserstoffproduktion durch Darmbakterien, die bei Morbus Parkinson spezifisch dysreguliert sind",
      "title_en": "Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease.",
      "title_de": null,
      "journal": "PloS one",
      "authors": "Suzuki et al.",
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      "doi": "10.1371/journal.pone.0208313",
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      "url": "https://h2medizin.org/studien/studie-suzuki-2018-quantifizierung-wasserstoffproduktion-darmbakterien-morbus/",
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    {
      "pmid": "30568387",
      "year": 2018,
      "title": "Wirkungen von alkalisch-elektrolysiertem und wasserstoffreichem Wasser in einem Mausmodell der nichtalkoholischen Fettlebererkrankung mit fettreicher Ernährung",
      "title_en": "Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model.",
      "title_de": null,
      "journal": "World journal of gastroenterology",
      "authors": "Jackson et al.",
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      "doi": "10.3748/wjg.v24.i45.5095",
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      "url": "https://h2medizin.org/studien/studie-jackson-2018-alkalisch-elektrolysiertem-wasserstoffreichem-einem/",
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    {
      "pmid": "30419521",
      "year": 2018,
      "title": "Effiziente Unterscheidung natürlicher Stereoisomere von Cichoriensäure, einem HIV-1-Integrase-Inhibitor",
      "title_en": "Efficient discrimination of natural stereoisomers of chicoric acid, an HIV-1 integrase inhibitor.",
      "title_de": null,
      "journal": "Journal of photochemistry and photobiology. B, Biology",
      "authors": "Nobela et al.",
      "author_search": "nobela nobela",
      "doi": "10.1016/j.jphotobiol.2018.10.025",
      "doi_url": "https://doi.org/10.1016/j.jphotobiol.2018.10.025",
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      "url": "https://h2medizin.org/studien/studie-nobela-2018-effiziente-unterscheidung-natuerlicher-stereoisomere/",
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    },
    {
      "pmid": "30396494",
      "year": 2018,
      "title": "Molekularer Wasserstoff könnte die Testosteronproduktion bei männlicher Infertilität durch Modulation von Hormonsignalen und Redox-Gleichgewicht steigern",
      "title_en": "Molecular hydrogen may enhance the production of testosterone hormone in male infertility through hormone signal modulation and redox balance.",
      "title_de": null,
      "journal": "Medical hypotheses",
      "authors": "Begum et al.",
      "author_search": "begum begum",
      "doi": "10.1016/j.mehy.2018.09.001",
      "doi_url": "https://doi.org/10.1016/j.mehy.2018.09.001",
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      "human": false,
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    {
      "pmid": "30382050",
      "year": 2018,
      "title": "Immunologische Wirkung von Wasserstoffgas: Wasserstoffgas verbessert die klinischen Ergebnisse von Krebspatienten",
      "title_en": "[Immunological Effect of Hydrogen Gas-Hydrogen Gas Improves Clinical Outcomes of Cancer Patients].",
      "title_de": null,
      "journal": "Gan to kagaku ryoho. Cancer & chemotherapy",
      "authors": "Akagi",
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      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30382050/",
      "url": "https://h2medizin.org/studien/studie-akagi-2018-immunologische-wasserstoffgas-wasserstoffgas-verbessert/",
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      "human": true,
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    {
      "pmid": "30380511",
      "year": 2018,
      "title": "Schützende Wirkungen von Wasserstoffgas gegen sepsis-induzierte akute Lungenschädigung über die Regulation der mitochondrialen Funktion und Dynamik",
      "title_en": "Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics.",
      "title_de": null,
      "journal": "International immunopharmacology",
      "authors": "Dong et al.",
      "author_search": "dong dong",
      "doi": "10.1016/j.intimp.2018.10.012",
      "doi_url": "https://doi.org/10.1016/j.intimp.2018.10.012",
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      "url": "https://h2medizin.org/studien/studie-dong-2018-schuetzende-wasserstoffgas-gegen-sepsis/",
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    },
    {
      "pmid": "30349057",
      "year": 2018,
      "title": "Co-Kulturen menschlicher Darmmikroben haben ein größeres Potenzial als Monokulturen für die Verwertung von Lebensmittelabfällen zu Grundchemikalien",
      "title_en": "Human gut microbe co-cultures have greater potential than monocultures for food waste remediation to commodity chemicals.",
      "title_de": null,
      "journal": "Scientific reports",
      "authors": "Perisin et al.",
      "author_search": "perisin perisin",
      "doi": "10.1038/s41598-018-33733-z",
      "doi_url": "https://doi.org/10.1038/s41598-018-33733-z",
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      "url": "https://h2medizin.org/studien/studie-perisin-2018-kulturen-menschlicher-darmmikroben-haben/",
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    {
      "pmid": "30120877",
      "year": 2018,
      "title": "Wasserstoff-Spülung nach Kaltlagerung als neue ischämieendständige Ex-vivo-Behandlung von Lebertransplantaten gegen Ischämie-/Reperfusionsschädigung",
      "title_en": "Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury.",
      "title_de": null,
      "journal": "Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society",
      "authors": "Tamaki et al.",
      "author_search": "tamaki tamaki",
      "doi": "10.1002/lt.25326",
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      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30120877/",
      "url": "https://h2medizin.org/studien/studie-tamaki-2018-spuelung-kaltlagerung-neue-ischaemieendstaendige/",
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    },
    {
      "pmid": "30096818",
      "year": 2018,
      "title": "Reduzierung der Feuchtigkeitsreaktion von Gassensoren für medizinische Anwendungen: Einsatz der Funkenentladungssynthese von Metalloxid-Nanopartikeln",
      "title_en": "Reducing Humidity Response of Gas Sensors for Medical Applications: Use of Spark Discharge Synthesis of Metal Oxide Nanoparticles.",
      "title_de": null,
      "journal": "Sensors (Basel, Switzerland)",
      "authors": "Vasiliev et al.",
      "author_search": "vasiliev vasiliev",
      "doi": "10.3390/s18082600",
      "doi_url": "https://doi.org/10.3390/s18082600",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30096818/",
      "url": "https://h2medizin.org/studien/studie-vasiliev-2018-reduzierung-feuchtigkeitsreaktion-gassensoren-medizinische/",
      "methods": [
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      "human": false,
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    },
    {
      "pmid": "30041222",
      "year": 2018,
      "title": "Translationale Forschung zu Peritonealdialyselösung mit gelöstem molekularem Wasserstoff",
      "title_en": "Translational Research of Peritoneal Dialysis Solution with Dissolved Molecular Hydrogen.",
      "title_de": null,
      "journal": "Contributions to nephrology",
      "authors": "Nakayama et al.",
      "author_search": "nakayama nakayama",
      "doi": "10.1159/000485717",
      "doi_url": "https://doi.org/10.1159/000485717",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/30041222/",
      "url": "https://h2medizin.org/studien/studie-nakayama-2018-translationale-forschung-peritonealdialyseloesung-geloestem/",
      "methods": [
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      "human": false,
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    },
    {
      "pmid": "29923670",
      "year": 2018,
      "title": "Ein In-situ-Depot zur kontinuierlichen Entwicklung von gasförmigem H₂, vermittelt durch einen Magnesium-Passivierungs-/Aktivierungszyklus, zur Behandlung von Osteoarthrose",
      "title_en": "An In Situ Depot for Continuous Evolution of Gaseous H2 Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis.",
      "title_de": null,
      "journal": "Angewandte Chemie (International ed. in English)",
      "authors": "Wan et al.",
      "author_search": "wan wan",
      "doi": "10.1002/anie.201806159",
      "doi_url": "https://doi.org/10.1002/anie.201806159",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29923670/",
      "url": "https://h2medizin.org/studien/studie-wan-2018-situ-depot-zur-kontinuierlichen/",
      "methods": [
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    },
    {
      "pmid": "29907217",
      "year": 2018,
      "title": "Wasserstoffreiches Wasser mildert oxidativen Stress bei Ratten mit traumatischer Hirnverletzung über den Nrf2-Signalweg",
      "title_en": "Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway.",
      "title_de": null,
      "journal": "The Journal of surgical research",
      "authors": "Yuan et al.",
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      "doi": "10.1016/j.jss.2018.03.024",
      "doi_url": "https://doi.org/10.1016/j.jss.2018.03.024",
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      "url": "https://h2medizin.org/studien/studie-yuan-2018-mildert-oxidativen-stress-ratten/",
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    {
      "pmid": "29901139",
      "year": 2018,
      "title": "Therapeutische Wirksamkeit von wasserstoffreicher Kochsalzlösung allein und in Kombination mit einem PI3K-Inhibitor beim nichtkleinzelligen Lungenkarzinom",
      "title_en": "Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer.",
      "title_de": null,
      "journal": "Molecular medicine reports",
      "authors": "Jiang et al.",
      "author_search": "jiang jiang",
      "doi": "10.3892/mmr.2018.9168",
      "doi_url": "https://doi.org/10.3892/mmr.2018.9168",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29901139/",
      "url": "https://h2medizin.org/studien/studie-jiang-2018-therapeutische-wasserstoffreicher-kochsalzloesung-allein/",
      "methods": [
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    {
      "pmid": "29852353",
      "year": 2018,
      "title": "Wasserstoffgas hemmt das Fortschreiten von Lungenkrebs durch gezielte Beeinflussung von SMC3",
      "title_en": "Hydrogen gas inhibits lung cancer progression through targeting SMC3.",
      "title_de": null,
      "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1016/j.biopha.2018.05.055",
      "doi_url": "https://doi.org/10.1016/j.biopha.2018.05.055",
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      "url": "https://h2medizin.org/studien/studie-wang-2018-wasserstoffgas-hemmt-fortschreiten-lungenkrebs/",
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    },
    {
      "pmid": "29795283",
      "year": 2018,
      "title": "Positive Wirkungen von Wasserstoff-Wasser-Bädern bei Patienten mit Psoriasis und Parapsoriasis en plaques",
      "title_en": "Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques.",
      "title_de": null,
      "journal": "Scientific reports",
      "authors": "Zhu et al.",
      "author_search": "zhu zhu",
      "doi": "10.1038/s41598-018-26388-3",
      "doi_url": "https://doi.org/10.1038/s41598-018-26388-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29795283/",
      "url": "https://h2medizin.org/studien/studie-zhu-2018-positive-baedern-psoriasis-parapsoriasis/",
      "methods": [
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    },
    {
      "pmid": "29779270",
      "year": 2018,
      "title": "Schützende Wirkungen von wasserstoffreichem Medium auf lipopolysaccharid-induzierte Schädigung in menschlichen Parodontalligamentzellen",
      "title_en": "[Protective effects of hydrogen-rich medium on lipopolysaccharides-induced injury in human periodontal ligament cells].",
      "title_de": null,
      "journal": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
      "authors": "Zhou et al.",
      "author_search": "zhou zhou",
      "doi": "10.7518/hxkq.2018.02.002",
      "doi_url": "https://doi.org/10.7518/hxkq.2018.02.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29779270/",
      "url": "https://h2medizin.org/studien/studie-zhou-2018-schuetzende-wasserstoffreichem-medium-lipopolysaccharid/",
      "methods": [
        "unspecified"
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        "oxidative-stress"
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      "human": false,
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    },
    {
      "pmid": "29712968",
      "year": 2018,
      "title": "Ein brennender Braunkohleflöz in den abgelegenen Altai-Bergen beherbergt eine wasserstoffgetriebene thermophile mikrobielle Gemeinschaft",
      "title_en": "Lignite coal burning seam in the remote Altai Mountains harbors a hydrogen-driven thermophilic microbial community.",
      "title_de": null,
      "journal": "Scientific reports",
      "authors": "Kadnikov et al.",
      "author_search": "kadnikov kadnikov",
      "doi": "10.1038/s41598-018-25146-9",
      "doi_url": "https://doi.org/10.1038/s41598-018-25146-9",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29712968/",
      "url": "https://h2medizin.org/studien/studie-kadnikov-2018-brennender-braunkohlefloez-den-abgelegenen/",
      "methods": [
        "unspecified"
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      "indications": [
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        "cancer"
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      "evidence_level": 1,
      "human": false,
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    },
    {
      "pmid": "29532858",
      "year": 2018,
      "title": "Wasserstoff mildert oxidativen Stress über den PI3K-Akt-Signalweg in UVB-induzierten HaCaT-Zellen",
      "title_en": "Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells.",
      "title_de": null,
      "journal": "International journal of molecular medicine",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.3892/ijmm.2018.3550",
      "doi_url": "https://doi.org/10.3892/ijmm.2018.3550",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29532858/",
      "url": "https://h2medizin.org/studien/studie-zhang-2018-mildert-oxidativen-stress-den/",
      "methods": [
        "unspecified"
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      "indications": [
        "cancer",
        "skin-aging",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "29532225",
      "year": 2018,
      "title": "Ein molekulardynamischer Ansatz zur Untersuchung der strukturellen Charakterisierung der katarakt-verursachenden Mutation R58H im menschlichen γD-Crystallin",
      "title_en": "A molecular dynamics approach to explore the structural characterization of cataract causing mutation R58H on human γD crystallin.",
      "title_de": null,
      "journal": "Molecular and cellular biochemistry",
      "authors": "Karunakaran et al.",
      "author_search": "karunakaran karunakaran",
      "doi": "10.1007/s11010-018-3342-8",
      "doi_url": "https://doi.org/10.1007/s11010-018-3342-8",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29532225/",
      "url": "https://h2medizin.org/studien/studie-karunakaran-2018-molekulardynamischer-ansatz-zur-untersuchung/",
      "methods": [
        "unspecified"
      ],
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        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29512923",
      "year": 2018,
      "title": "Modulation des oxidativen Plasmazustands bei gastroösophagealer Refluxkrankheit durch Zusatz von molekular-wasserstoffreichem Wasser: Eine neue biologische Sichtweise",
      "title_en": "Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision.",
      "title_de": null,
      "journal": "Journal of cellular and molecular medicine",
      "authors": "Franceschelli et al.",
      "author_search": "franceschelli franceschelli",
      "doi": "10.1111/jcmm.13569",
      "doi_url": "https://doi.org/10.1111/jcmm.13569",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29512923/",
      "url": "https://h2medizin.org/studien/studie-franceschelli-2018-modulation-des-oxidativen-plasmazustands/",
      "methods": [
        "unspecified"
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      "indications": [
        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 2,
      "human": true,
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      "h2category": "therapy"
    },
    {
      "pmid": "29478695",
      "year": 2018,
      "title": "Unzureichende Produktion von H₂ durch die Darmmikrobiota und Morbus Parkinson",
      "title_en": "Inadequate Production of H2 by Gut Microbiota and Parkinson Disease.",
      "title_de": null,
      "journal": "Trends in endocrinology and metabolism: TEM",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1016/j.tem.2018.02.006",
      "doi_url": "https://doi.org/10.1016/j.tem.2018.02.006",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29478695/",
      "url": "https://h2medizin.org/studien/studie-ostojic-2018-unzureichende-produktion-darmmikrobiota-morbus/",
      "methods": [
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      "indications": [
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        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "29321509",
      "year": 2018,
      "title": "Neuartige Hämodialyse-Behandlung mit einer mit molekularem Wasserstoff angereicherten Dialyselösung verbessert die Prognose chronischer Dialysepatienten: Eine prospektive Beobachtungsstudie",
      "title_en": "Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study.",
      "title_de": null,
      "journal": "Scientific reports",
      "authors": "Nakayama et al.",
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      "doi": "10.1038/s41598-017-18537-x",
      "doi_url": "https://doi.org/10.1038/s41598-017-18537-x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29321509/",
      "url": "https://h2medizin.org/studien/studie-nakayama-2018-neuartige-haemodialyse-angereicherten-dialyseloesung/",
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    {
      "pmid": "28474871",
      "year": 2018,
      "title": "Wirkungen von wasserstoffreichem Wasser auf verlängerte intermittierende Belastung",
      "title_en": "Effects of hydrogen rich water on prolonged intermittent exercise.",
      "title_de": null,
      "journal": "The Journal of sports medicine and physical fitness",
      "authors": "Da Ponte et al.",
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      "doi": "10.23736/s0022-4707.17.06883-9",
      "doi_url": "https://doi.org/10.23736/s0022-4707.17.06883-9",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28474871/",
      "url": "https://h2medizin.org/studien/studie-daponte-2018-wasserstoffreichem-verlaengerte-intermittierende-belastung/",
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    {
      "pmid": "27281176",
      "year": 2017,
      "title": "Molekularer Wasserstoff als neuroprotektives Agens",
      "title_en": "Molecular Hydrogen as a Neuroprotective Agent",
      "title_de": null,
      "journal": "Current Neuropharmacology",
      "authors": "Iketani et al.",
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      "doi": "10.2174/1570159x14666160607205417",
      "doi_url": "https://doi.org/10.2174/1570159x14666160607205417",
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      "url": "https://h2medizin.org/studien/studie-iketani-2017-neuroprotektives-agens/",
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    {
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      "year": 2017,
      "title": "Wirksamkeit von inhaliertem Wasserstoff auf das neurologische Ergebnis nach Hirnischämie während der Versorgung nach Herzstillstand (HYBRID-II-Studie): Studienprotokoll für eine randomisierte kontrollierte Studie",
      "title_en": "Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial.",
      "title_de": null,
      "journal": "Trials",
      "authors": "Tamura et al.",
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      "doi": "10.1186/s13063-017-2246-3",
      "doi_url": "https://doi.org/10.1186/s13063-017-2246-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29058596/",
      "url": "https://h2medizin.org/studien/studie-tamura-2017-inhaliertem-neurologische-ergebnis-hirnischaemie/",
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    {
      "pmid": "28669654",
      "year": 2017,
      "title": "Behandlung mit Wasserstoffgas-Inhalation beim akuten Hirninfarkt: Eine randomisierte kontrollierte klinische Studie zu Sicherheit und Neuroprotektion.",
      "title_en": "Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.",
      "title_de": null,
      "journal": "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association",
      "authors": "Ono et al.",
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      "doi": "10.1016/j.jstrokecerebrovasdis.2017.06.012",
      "doi_url": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28669654/",
      "url": "https://h2medizin.org/studien/studie-ono-2017-wasserstoffgas-inhalation-beim-akuten/",
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    {
      "pmid": "30998612",
      "year": 2017,
      "title": "Schützende Wirkung der Wasserstoffgas-Inhalation auf Muskelschäden anhand eines Maus-Hinterlauf-Ischämie-Reperfusions-Schädigungsmodells",
      "title_en": "Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model.",
      "title_de": null,
      "journal": "Plastic and reconstructive surgery",
      "authors": "Watanabe et al.",
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      "doi": "10.1097/prs.0000000000003878",
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      "url": "https://h2medizin.org/studien/studie-watanabe-2017-schuetzende-wasserstoffgas-inhalation-muskelschaeden/",
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    {
      "pmid": "28902900",
      "year": 2017,
      "title": "Mögliche klinische Wirkungen der Zufuhr von molekularem Wasserstoff (H₂) während der Hämodialyse bei chronischen Dialysepatienten: Zwischenanalyse einer 12-monatigen Beobachtung.",
      "title_en": "Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.",
      "title_de": null,
      "journal": "PloS one",
      "authors": "Nakayama et al.",
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      "doi": "10.1371/journal.pone.0184535",
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      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28902900/",
      "url": "https://h2medizin.org/studien/studie-nakayama-2017-moegliche-klinische-zufuhr-waehrend/",
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    {
      "pmid": "28856162",
      "year": 2017,
      "title": "Produktion von wasserstoffreichem Synthesegas aus Vergasung und Pyrolyse von solar getrocknetem Klärschlamm: Experimentelle und Modellierungsuntersuchungen",
      "title_en": "Hydrogen-Rich Syngas Production from Gasification and Pyrolysis of Solar Dried Sewage Sludge: Experimental and Modeling Investigations.",
      "title_de": null,
      "journal": "BioMed research international",
      "authors": "Ben Hassen Trabelsi et al.",
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      "doi": "10.1155/2017/7831470",
      "doi_url": "https://doi.org/10.1155/2017/7831470",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28856162/",
      "url": "https://h2medizin.org/studien/studie-benhassentrabelsi-2017-produktion-wasserstoffreichem-synthesegas-aus/",
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    {
      "pmid": "28566655",
      "year": 2017,
      "title": "Translationale Studie zur Wasserstoffgas-Inhalation als Ergänzung zur Reperfusionstherapie beim akuten Myokardinfarkt",
      "title_en": "Translational Study of Hydrogen Gas Inhalation as Adjuncts to Reperfusion Therapy for Acute Myocardial Infarction.",
      "title_de": null,
      "journal": "Circulation journal : official journal of the Japanese Circulation Society",
      "authors": "Asanuma et al.",
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      "doi": "10.1253/circj.cj-17-0520",
      "doi_url": "https://doi.org/10.1253/circj.cj-17-0520",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28566655/",
      "url": "https://h2medizin.org/studien/studie-asanuma-2017-translationale-zur-wasserstoffgas-inhalation/",
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    {
      "pmid": "28467497",
      "year": 2017,
      "title": "Molekularer Wasserstoff schützt vor durch oxidativen Stress induziertem Zelltod von SH-SY5Y-Neuroblastomzellen durch den Prozess der Mitohormesis",
      "title_en": "Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis.",
      "title_de": null,
      "journal": "PloS one",
      "authors": "Murakami et al.",
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      "doi": "10.1371/journal.pone.0176992",
      "doi_url": "https://doi.org/10.1371/journal.pone.0176992",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28467497/",
      "url": "https://h2medizin.org/studien/studie-murakami-2017-schuetzt-vor-oxidativen-stress/",
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    {
      "pmid": "28458345",
      "year": 2017,
      "title": "Wasserstoffreiches Wasser mildert Nierenschädigung und -fibrose durch Regulation des durch TGF-β induzierten Sirt1",
      "title_en": "Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-β Induced Sirt1.",
      "title_de": null,
      "journal": "Biological & pharmaceutical bulletin",
      "authors": "Xing et al.",
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      "doi": "10.1248/bpb.b16-00832",
      "doi_url": "https://doi.org/10.1248/bpb.b16-00832",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28458345/",
      "url": "https://h2medizin.org/studien/studie-xing-2017-mildert-nierenschaedigung-fibrose-regulation/",
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    },
    {
      "pmid": "28374556",
      "year": 2017,
      "title": "Therapeutische Wirkungen von Wasserstoff auf die chronische Graft-versus-Host-Erkrankung.",
      "title_en": "Therapeutic effects of hydrogen on chronic graft-versus-host disease.",
      "title_de": null,
      "journal": "Journal of cellular and molecular medicine",
      "authors": "Qian et al.",
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      "doi": "10.1111/jcmm.13155",
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      "url": "https://h2medizin.org/studien/studie-qian-2017-therapeutische-chronische-graft-versus/",
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    {
      "pmid": "28321000",
      "year": 2017,
      "title": "Die Wirkungen der Wasserstoffgas-Inhalation auf das ungünstige linksventrikuläre Remodeling nach perkutaner Koronarintervention bei ST-Hebungsinfarkt — erste Pilotstudie am Menschen.",
      "title_en": "The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction　- First Pilot Study in Humans.",
      "title_de": null,
      "journal": "Circulation journal : official journal of the Japanese Circulation Society",
      "authors": "Katsumata et al.",
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      "doi": "10.1253/circj.cj-17-0105",
      "doi_url": "https://doi.org/10.1253/circj.cj-17-0105",
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      "url": "https://h2medizin.org/studien/studie-katsumata-2017-wasserstoffgas-inhalation-unguenstige-linksventrikulaere/",
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    {
      "pmid": "28215576",
      "year": 2017,
      "title": "Veränderungen der IL-4- und IL-13-Expression bei allergischer Rhinitis, behandelt mit wasserstoffreicher Kochsalzlösung im Meerschweinchenmodell",
      "title_en": "Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model.",
      "title_de": null,
      "journal": "Allergologia et immunopathologia",
      "authors": "Zhao et al.",
      "author_search": "zhao zhao",
      "doi": "10.1016/j.aller.2016.10.007",
      "doi_url": "https://doi.org/10.1016/j.aller.2016.10.007",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28215576/",
      "url": "https://h2medizin.org/studien/studie-zhao-2017-veraenderungen-expression-allergischer-rhinitis/",
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    {
      "pmid": "28189762",
      "year": 2017,
      "title": "Eine umfassende computergestützte Studie zu pathogenen Missense-Mutationen in den RING2- und REP-Domänen des Parkin-Proteins",
      "title_en": "A comprehensive computational study on pathogenic mis-sense mutations spanning the RING2 and REP domains of Parkin protein.",
      "title_de": null,
      "journal": "Gene",
      "authors": "Biswas et al.",
      "author_search": "biswas biswas",
      "doi": "10.1016/j.gene.2017.02.008",
      "doi_url": "https://doi.org/10.1016/j.gene.2017.02.008",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28189762/",
      "url": "https://h2medizin.org/studien/studie-biswas-2017-umfassende-computergestuetzte-pathogenen-missense/",
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    {
      "pmid": "28148301",
      "year": 2017,
      "title": "Schützende Wirkungen von molekularem Wasserstoff auf die steroidinduzierte Osteonekrose bei Kaninchen durch Reduktion von oxidativem Stress und Apoptose",
      "title_en": "Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.",
      "title_de": null,
      "journal": "BMC musculoskeletal disorders",
      "authors": "Li et al.",
      "author_search": "li li",
      "doi": "10.1186/s12891-017-1431-6",
      "doi_url": "https://doi.org/10.1186/s12891-017-1431-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28148301/",
      "url": "https://h2medizin.org/studien/studie-li-2017-schuetzende-steroidinduzierte-osteonekrose-kaninchen/",
      "methods": [
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    {
      "pmid": "28087297",
      "year": 2017,
      "title": "Hemmung von Streptokokken-Biofilm durch Wasserstoffwasser",
      "title_en": "Inhibition of streptococcal biofilm by hydrogen water.",
      "title_de": null,
      "journal": "Journal of dentistry",
      "authors": "Kim et al.",
      "author_search": "kim kim",
      "doi": "10.1016/j.jdent.2017.01.004",
      "doi_url": "https://doi.org/10.1016/j.jdent.2017.01.004",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/28087297/",
      "url": "https://h2medizin.org/studien/studie-kim-2017-hemmung-streptokokken-biofilm-wasserstoffwasser/",
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    {
      "pmid": "27965418",
      "year": 2017,
      "title": "Nicht-Darm-Mikrobiota als Quelle bioaktiven Wasserstoffs",
      "title_en": "Non-gut microbiota as a source of bioactive hydrogen.",
      "title_de": null,
      "journal": "Postgraduate medical journal",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1136/postgradmedj-2016-134411",
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      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27965418/",
      "url": "https://h2medizin.org/studien/studie-ostojic-2017-nicht-darm-mikrobiota-quelle/",
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    {
      "pmid": "27780950",
      "year": 2017,
      "title": "Wasserstoffbehandlung schützt vor Zelltod und Seneszenz, die durch oxidative Schädigung induziert werden",
      "title_en": "Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage.",
      "title_de": null,
      "journal": "Journal of microbiology and biotechnology",
      "authors": "Han et al.",
      "author_search": "han han",
      "doi": "10.4014/jmb.1608.08011",
      "doi_url": "https://doi.org/10.4014/jmb.1608.08011",
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      "url": "https://h2medizin.org/studien/studie-han-2017-wasserstoffbehandlung-schuetzt-vor-zelltod/",
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    {
      "pmid": "27770674",
      "year": 2017,
      "title": "Bewertung von alkalisch-elektrolysiertem Wasser als Ersatz für traditionelle Phosphat-Verbesserungslösungen: Wirkungen auf Wasserbindungsvermögen, Zartheit und sensorische Eigenschaften",
      "title_en": "Evaluation of alkaline electrolyzed water to replace traditional phosphate enhancement solutions: Effects on water holding capacity, tenderness, and sensory characteristics.",
      "title_de": null,
      "journal": "Meat science",
      "authors": "Rigdon et al.",
      "author_search": "rigdon rigdon",
      "doi": "10.1016/j.meatsci.2016.10.007",
      "doi_url": "https://doi.org/10.1016/j.meatsci.2016.10.007",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27770674/",
      "url": "https://h2medizin.org/studien/studie-rigdon-2017-bewertung-alkalisch-elektrolysiertem-ersatz/",
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    },
    {
      "pmid": "27777424",
      "year": 2016,
      "title": "Die klinische Anwendung von Wasserstoff als medizinische Behandlung",
      "title_en": "The Clinical Application of Hydrogen as a Medical Treatment.",
      "title_de": null,
      "journal": "Acta medica Okayama",
      "authors": "Iida et al.",
      "author_search": "iida iida",
      "doi": "10.18926/amo/54590",
      "doi_url": "https://doi.org/10.18926/amo/54590",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27777424/",
      "url": "https://h2medizin.org/studien/studie-iida-2016-klinische-anwendung-medizinische/",
      "methods": [
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      "h2category": "review"
    },
    {
      "pmid": "27643933",
      "year": 2016,
      "title": "Präventive und therapeutische Anwendung von molekularem Wasserstoff bei Situationen mit übermäßiger Produktion freier Radikale",
      "title_en": "Preventive and therapeutic application of molecular hydrogen in situations with excessive production of free radicals.",
      "title_de": null,
      "journal": "Physiological research",
      "authors": "Slezák et al.",
      "author_search": "slezák slezák",
      "doi": "10.33549/physiolres.933414",
      "doi_url": "https://doi.org/10.33549/physiolres.933414",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27643933/",
      "url": "https://h2medizin.org/studien/studie-slezak-2016-praeventive-therapeutische-anwendung-situationen/",
      "methods": [
        "unspecified"
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      "human": false,
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      "h2category": "review"
    },
    {
      "pmid": "27413421",
      "year": 2016,
      "title": "Therapie mit molekularem Wasserstoff mildert die durch Sepsis induzierte Organschädigung",
      "title_en": "Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis.",
      "title_de": null,
      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Zheng et al.",
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      "doi": "10.1155/2016/5806057",
      "doi_url": "https://doi.org/10.1155/2016/5806057",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27413421/",
      "url": "https://h2medizin.org/studien/studie-zheng-2016-mildert-sepsis-induzierte-organschaedigung/",
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        "unspecified"
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      "evidence_level": 4,
      "human": false,
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    {
      "pmid": "27154268",
      "year": 2016,
      "title": "Die Fünferregel 2015 und darüber hinaus: strukturelle Beschränkungen von Zielmolekül und Ligand, Ligandchemie-Struktur und Entscheidungen in Wirkstoffentdeckungsprojekten",
      "title_en": "Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions.",
      "title_de": null,
      "journal": "Advanced drug delivery reviews",
      "authors": "Lipinski",
      "author_search": "lipinski lipinski",
      "doi": "10.1016/j.addr.2016.04.029",
      "doi_url": "https://doi.org/10.1016/j.addr.2016.04.029",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27154268/",
      "url": "https://h2medizin.org/studien/studie-lipinski-2016-fuenferregel-2015-darueber-hinaus/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
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    },
    {
      "pmid": "26642800",
      "year": 2016,
      "title": "Komplementäre Therapien beim Blasenschmerzsyndrom: eine systematische Übersichtsarbeit",
      "title_en": "Complementary therapies for bladder pain syndrome: a systematic review.",
      "title_de": null,
      "journal": "International urogynecology journal",
      "authors": "Verghese et al.",
      "author_search": "verghese verghese",
      "doi": "10.1007/s00192-015-2886-3",
      "doi_url": "https://doi.org/10.1007/s00192-015-2886-3",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26642800/",
      "url": "https://h2medizin.org/studien/studie-verghese-2016-komplementaere-therapien-beim-blasenschmerzsyndrom/",
      "methods": [
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      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "27938540",
      "year": 2016,
      "title": "Schützende Wirkung von Wasserstoff auf die Lunge von Reinigungsarbeitern, die Smog ausgesetzt sind.",
      "title_en": "[Protective effect of hydrogen on the lung of sanitation workers exposed to haze].",
      "title_de": null,
      "journal": "Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases",
      "authors": "Gong et al.",
      "author_search": "gong gong",
      "doi": "10.3760/cma.j.issn.1001-0939.2016.12.003",
      "doi_url": "https://doi.org/10.3760/cma.j.issn.1001-0939.2016.12.003",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27938540/",
      "url": "https://h2medizin.org/studien/studie-gong-2016-schuetzende-lunge-reinigungsarbeitern-smog/",
      "methods": [
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      "evidence_level": 3,
      "human": true,
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    {
      "pmid": "27176725",
      "year": 2016,
      "title": "Eine randomisierte doppelblinde multizentrische Studie zu Wasserstoffwasser bei Morbus Parkinson: Protokoll und Ausgangscharakteristika.",
      "title_en": "A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics.",
      "title_de": null,
      "journal": "BMC neurology",
      "authors": "Yoritaka et al.",
      "author_search": "yoritaka yoritaka",
      "doi": "10.1186/s12883-016-0589-0",
      "doi_url": "https://doi.org/10.1186/s12883-016-0589-0",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27176725/",
      "url": "https://h2medizin.org/studien/studie-yoritaka-2016-multizentrische-wasserstoffwasser-morbus-parkinson/",
      "methods": [
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      "evidence_level": 3,
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    },
    {
      "pmid": "27606690",
      "year": 2016,
      "title": "Wasserstoffreiche Kochsalzlösung als innovative Therapie bei Katarakt: Eine Hypothese",
      "title_en": "Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.",
      "title_de": null,
      "journal": "Medical science monitor : international medical journal of experimental and clinical research",
      "authors": "Qin et al.",
      "author_search": "qin qin",
      "doi": "10.12659/msm.899807",
      "doi_url": "https://doi.org/10.12659/msm.899807",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27606690/",
      "url": "https://h2medizin.org/studien/studie-qin-2016-wasserstoffreiche-kochsalzloesung-innovative-katarakt/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
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    },
    {
      "pmid": "27598129",
      "year": 2016,
      "title": "Neuer Ansatz in der translationalen Medizin: Wirkungen von elektrolysiertem reduziertem Wasser (ERW) auf den NF-κB/iNOS-Signalweg in der U937-Zelllinie bei verändertem Redox-Zustand",
      "title_en": "New Approach in Translational Medicine: Effects of Electrolyzed Reduced Water (ERW) on NF-κB/iNOS Pathway in U937 Cell Line under Altered Redox State.",
      "title_de": null,
      "journal": "International journal of molecular sciences",
      "authors": "Franceschelli et al.",
      "author_search": "franceschelli franceschelli",
      "doi": "10.3390/ijms17091461",
      "doi_url": "https://doi.org/10.3390/ijms17091461",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27598129/",
      "url": "https://h2medizin.org/studien/studie-franceschelli-2016-neuer-ansatz-translationalen-medizin/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
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    },
    {
      "pmid": "27558955",
      "year": 2016,
      "title": "Molekularer Wasserstoff unterdrückt aktivierte Wnt/β-Catenin-Signalübertragung",
      "title_en": "Molecular hydrogen suppresses activated Wnt/β-catenin signaling.",
      "title_de": null,
      "journal": "Scientific reports",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.1038/srep31986",
      "doi_url": "https://doi.org/10.1038/srep31986",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27558955/",
      "url": "https://h2medizin.org/studien/studie-lin-2016-unterdrueckt-aktivierte-wnt-catenin/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
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    },
    {
      "pmid": "27531909",
      "year": 2016,
      "title": "Der Wasserstoffstoffwechsel in Helicobacter pylori spielt eine Rolle bei der Magenkarzinogenese durch Erleichterung der CagA-Translokation",
      "title_en": "Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation.",
      "title_de": null,
      "journal": "mBio",
      "authors": "Wang et al.",
      "author_search": "wang wang",
      "doi": "10.1128/mbio.01022-16",
      "doi_url": "https://doi.org/10.1128/mbio.01022-16",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27531909/",
      "url": "https://h2medizin.org/studien/studie-wang-2016-wasserstoffstoffwechsel-helicobacter-pylori-spielt/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
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    },
    {
      "pmid": "27477846",
      "year": 2016,
      "title": "Molekularer Wasserstoff mildert zelluläre Seneszenz in Endothelzellen",
      "title_en": "Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells.",
      "title_de": null,
      "journal": "Circulation journal : official journal of the Japanese Circulation Society",
      "authors": "Hara et al.",
      "author_search": "hara hara",
      "doi": "10.1253/circj.cj-16-0227",
      "doi_url": "https://doi.org/10.1253/circj.cj-16-0227",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27477846/",
      "url": "https://h2medizin.org/studien/studie-hara-2016-mildert-zellulaere-seneszenz-endothelzellen/",
      "methods": [
        "inhalation",
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        "skin-aging",
        "immune-system",
        "oxidative-stress"
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      "evidence_level": 1,
      "human": false,
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    },
    {
      "pmid": "27448107",
      "year": 2016,
      "title": "Molekularer Wasserstoff in der menschlichen Atemluft: eine neue Strategie zur selektiven Diagnose von peptischem Ulkus, nicht-ulzeröser Dyspepsie und Helicobacter-pylori-Infektion.",
      "title_en": "Molecular hydrogen in human breath: a new strategy for selectively diagnosing peptic ulcer disease, non-ulcerous dyspepsia and Helicobacter pylori infection.",
      "title_de": null,
      "journal": "Journal of breath research",
      "authors": "Maity et al.",
      "author_search": "maity maity",
      "doi": "10.1088/1752-7155/10/3/036007",
      "doi_url": "https://doi.org/10.1088/1752-7155/10/3/036007",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27448107/",
      "url": "https://h2medizin.org/studien/studie-maity-2016-menschlichen-atemluft-neue-strategie/",
      "methods": [],
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        "respiratory"
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      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "27344261",
      "year": 2016,
      "title": "Eine Revision der Wasserstoff-Isotopenzusammensetzung der stabilen Isotopen-Referenzmaterialien USGS42 und USGS43 aus menschlichem Haar für die forensische Wissenschaft",
      "title_en": "A revision in hydrogen isotopic composition of USGS42 and USGS43 human-hair stable isotopic reference materials for forensic science.",
      "title_de": null,
      "journal": "Forensic science international",
      "authors": "Coplen et al.",
      "author_search": "coplen coplen",
      "doi": "10.1016/j.forsciint.2016.05.029",
      "doi_url": "https://doi.org/10.1016/j.forsciint.2016.05.029",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27344261/",
      "url": "https://h2medizin.org/studien/studie-coplen-2016-revision-isotopenzusammensetzung-stabilen-isotopen/",
      "methods": [
        "unspecified"
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      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "27334126",
      "year": 2016,
      "title": "Durchführbarkeit und Sicherheit der Wasserstoffgas-Inhalation beim Post-Cardiac-Arrest-Syndrom — erste Pilotstudie am Menschen.",
      "title_en": "Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　- First-in-Human Pilot Study.",
      "title_de": null,
      "journal": "Circulation journal : official journal of the Japanese Circulation Society",
      "authors": "Tamura et al.",
      "author_search": "tamura tamura",
      "doi": "10.1253/circj.cj-16-0127",
      "doi_url": "https://doi.org/10.1253/circj.cj-16-0127",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27334126/",
      "url": "https://h2medizin.org/studien/studie-tamura-2016-durchfuehrbarkeit-sicherheit-wasserstoffgas-inhalation/",
      "methods": [
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      "evidence_level": 2,
      "human": true,
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    },
    {
      "pmid": "27123663",
      "year": 2016,
      "title": "Der H₂-Metabolismus ist unter menschlichen Kolonmikroben weit verbreitet und vielfältig",
      "title_en": "H2 metabolism is widespread and diverse among human colonic microbes.",
      "title_de": null,
      "journal": "Gut microbes",
      "authors": "Wolf et al.",
      "author_search": "wolf wolf",
      "doi": "10.1080/19490976.2016.1182288",
      "doi_url": "https://doi.org/10.1080/19490976.2016.1182288",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/27123663/",
      "url": "https://h2medizin.org/studien/studie-wolf-2016-metabolismus-ist-unter-menschlichen/",
      "methods": [
        "unspecified"
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      "indications": [
        "metabolic",
        "sports-exercise",
        "eye",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "26947809",
      "year": 2016,
      "title": "Dock 'n roll: Faltung eines seiden-inspirierten Polypeptids in ein amyloidähnliches Beta-Solenoid",
      "title_en": "Dock 'n roll: folding of a silk-inspired polypeptide into an amyloid-like beta solenoid.",
      "title_de": null,
      "journal": "Soft matter",
      "authors": "Zhao et al.",
      "author_search": "zhao zhao",
      "doi": "10.1039/c6sm00169f",
      "doi_url": "https://doi.org/10.1039/c6sm00169f",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26947809/",
      "url": "https://h2medizin.org/studien/studie-zhao-2016-dock-roll-faltung-seiden/",
      "methods": [
        "unspecified"
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        "other"
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      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "26927488",
      "year": 2016,
      "title": "Entdeckung neuartiger 2-Phenyl-imidazo[1,2-a]pyridin-Analoga, die auf die Tubulin-Polymerisation als antiproliferative Wirkstoffe abzielen",
      "title_en": "Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents.",
      "title_de": null,
      "journal": "European journal of medicinal chemistry",
      "authors": "An et al.",
      "author_search": "an an",
      "doi": "10.1016/j.ejmech.2016.02.004",
      "doi_url": "https://doi.org/10.1016/j.ejmech.2016.02.004",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26927488/",
      "url": "https://h2medizin.org/studien/studie-an-2016-entdeckung-neuartiger-phenyl-imidazo/",
      "methods": [
        "unspecified"
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      "indications": [
        "cancer"
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "29917336",
      "year": 2016,
      "title": "Wirkungen von wasserstoffreichem Medium auf die lipopolysaccharid-induzierte Funktionsstörung der intestinalen Epithelbarriere menschlicher Kolonkarzinomzellen",
      "title_en": "[Effects of hydrogen-rich medium on lipopolysaccharide-induced intestinal epithelial barrier dysfunction of human colon carcinoma cells].",
      "title_de": null,
      "journal": "Zhonghua wei zhong bing ji jiu yi xue",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/29917336/",
      "url": "https://h2medizin.org/studien/studie-yang-2016-wasserstoffreichem-medium-lipopolysaccharid-induzierte/",
      "methods": [
        "saline-iv"
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      "indications": [
        "cancer",
        "pregnancy"
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      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "26912054",
      "year": 2016,
      "title": "Optisch induzierte Zellfusion auf Zellpaarungs-Mikrostrukturen",
      "title_en": "Optically-Induced Cell Fusion on Cell Pairing Microstructures.",
      "title_de": null,
      "journal": "Scientific reports",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.1038/srep22036",
      "doi_url": "https://doi.org/10.1038/srep22036",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26912054/",
      "url": "https://h2medizin.org/studien/studie-yang-2016-optisch-induzierte-zellfusion-zellpaarungs/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "cancer"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26845501",
      "year": 2016,
      "title": "Wasserstoffreiches Wasser mildert die bronchopulmonale Dysplasie (BPD) bei neugeborenen Ratten",
      "title_en": "Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats.",
      "title_de": null,
      "journal": "Pediatric pulmonology",
      "authors": "Muramatsu et al.",
      "author_search": "muramatsu muramatsu",
      "doi": "10.1002/ppul.23386",
      "doi_url": "https://doi.org/10.1002/ppul.23386",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26845501/",
      "url": "https://h2medizin.org/studien/studie-muramatsu-2016-mildert-bronchopulmonale-dysplasie-bpd/",
      "methods": [
        "inhalation",
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      "indications": [
        "cancer",
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        "immune-system",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26777153",
      "year": 2016,
      "title": "Wie der Imidazolring die Amyloidbildung des Inselamyloid-Polypeptids moduliert: Eine chemische Modifikationsstudie",
      "title_en": "How the imidazole ring modulates amyloid formation of islet amyloid polypeptide: A chemical modification study.",
      "title_de": null,
      "journal": "Biochimica et biophysica acta",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1016/j.bbagen.2016.01.008",
      "doi_url": "https://doi.org/10.1016/j.bbagen.2016.01.008",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26777153/",
      "url": "https://h2medizin.org/studien/studie-zhang-2016-wie-imidazolring-amyloidbildung-des/",
      "methods": [
        "unspecified"
      ],
      "indications": [
        "diabetes"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26739257",
      "year": 2016,
      "title": "Molekularer Wasserstoff reguliert die Genexpression durch Modifikation der von der Radikalkettenreaktion abhängigen Erzeugung oxidierter Phospholipid-Mediatoren",
      "title_en": "Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators.",
      "title_de": null,
      "journal": "Scientific reports",
      "authors": "Iuchi et al.",
      "author_search": "iuchi iuchi",
      "doi": "10.1038/srep18971",
      "doi_url": "https://doi.org/10.1038/srep18971",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26739257/",
      "url": "https://h2medizin.org/studien/studie-iuchi-2016-reguliert-genexpression-modifikation-radikalkettenreaktion/",
      "methods": [
        "inhalation"
      ],
      "indications": [
        "metabolic",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26714124",
      "year": 2016,
      "title": "Wasserstoffreiche Kochsalzlösung mildert akute Nierenschädigung nach Lebertransplantation durch Aktivierung der p53-vermittelten Autophagie",
      "title_en": "Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy.",
      "title_de": null,
      "journal": "Transplantation",
      "authors": "Du et al.",
      "author_search": "du du",
      "doi": "10.1097/tp.0000000000001052",
      "doi_url": "https://doi.org/10.1097/tp.0000000000001052",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26714124/",
      "url": "https://h2medizin.org/studien/studie-du-2016-wasserstoffreiche-kochsalzloesung-mildert-akute/",
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    },
    {
      "pmid": "26657415",
      "year": 2016,
      "title": "Ist Melanin eine Quelle bioaktiven molekularen Wasserstoffs?",
      "title_en": "Is melanin a source of bioactive molecular hydrogen?",
      "title_de": null,
      "journal": "Pharmacological research",
      "authors": "Ostojic et al.",
      "author_search": "ostojic ostojic",
      "doi": "10.1016/j.phrs.2015.12.002",
      "doi_url": "https://doi.org/10.1016/j.phrs.2015.12.002",
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      "url": "https://h2medizin.org/studien/studie-ostojic-2016-ist-melanin-quelle-bioaktiven/",
      "methods": [
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    {
      "pmid": "26631313",
      "year": 2016,
      "title": "Design und Optimierung selektiver Azaindolamid-M1-positiver allosterischer Modulatoren",
      "title_en": "Design and optimization of selective azaindole amide M1 positive allosteric modulators.",
      "title_de": null,
      "journal": "Bioorganic & medicinal chemistry letters",
      "authors": "Davoren et al.",
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      "doi": "10.1016/j.bmcl.2015.11.053",
      "doi_url": "https://doi.org/10.1016/j.bmcl.2015.11.053",
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      "url": "https://h2medizin.org/studien/studie-davoren-2016-design-optimierung-selektiver-azaindolamid/",
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      "human": false,
      "therapeutic": false,
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    },
    {
      "pmid": "26537817",
      "year": 2016,
      "title": "Behandlung mit wasserstoffreicher Kochsalzlösung verzögert das Fortschreiten der Erkrankung in einem Mausmodell der amyotrophen Lateralsklerose",
      "title_en": "Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis.",
      "title_de": null,
      "journal": "Neurochemical research",
      "authors": "Zhang et al.",
      "author_search": "zhang zhang",
      "doi": "10.1007/s11064-015-1750-7",
      "doi_url": "https://doi.org/10.1007/s11064-015-1750-7",
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      "url": "https://h2medizin.org/studien/studie-zhang-2016-wasserstoffreicher-kochsalzloesung-verzoegert-fortschreiten/",
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    {
      "pmid": "26529665",
      "year": 2016,
      "title": "Wasserstoffreiches Medium mildert die lipopolysaccharid-induzierte Barrierefunktionsstörung über die RhoA-mDia1-Signalübertragung in Caco-2-Zellen",
      "title_en": "HYDROGEN-RICH MEDIUM AMELIORATES LIPOPOLYSACCHARIDE-INDUCED BARRIER DYSFUNCTION VIA RHOA-MDIA1 SIGNALING IN CACO-2 CELLS.",
      "title_de": null,
      "journal": "Shock (Augusta, Ga.)",
      "authors": "Yang et al.",
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      "doi": "10.1097/shk.0000000000000503",
      "doi_url": "https://doi.org/10.1097/shk.0000000000000503",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26529665/",
      "url": "https://h2medizin.org/studien/studie-yang-2016-medium-mildert-lipopolysaccharid-induzierte/",
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    {
      "pmid": "26012504",
      "year": 2016,
      "title": "Antioxidantien und K⁺-Kanal-Agonisten versus Wasserstofftherapie während der Ex-vivo-Lungenperfusion",
      "title_en": "Antioxidants and K+ channel agonists versus hydrogen therapy during ex vivo lung perfusion†.",
      "title_de": null,
      "journal": "European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery",
      "authors": "Mohamed",
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      "doi": "10.1093/ejcts/ezv192",
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      "url": "https://h2medizin.org/studien/studie-mohamed-2016-antioxidantien-kanal-agonisten-versus/",
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      "human": false,
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    {
      "pmid": "25671669",
      "year": 2016,
      "title": "Das Multiresistenzprofil der PR20-HIV-1-Protease wird einer verzerrten Konformations- und Wirkstoffbindungslandschaft zugeschrieben: Erkenntnisse aus der Molekulardynamik",
      "title_en": "Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights.",
      "title_de": null,
      "journal": "Journal of biomolecular structure & dynamics",
      "authors": "Chetty et al.",
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      "doi": "10.1080/07391102.2015.1018326",
      "doi_url": "https://doi.org/10.1080/07391102.2015.1018326",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25671669/",
      "url": "https://h2medizin.org/studien/studie-chetty-2016-multiresistenzprofil-pr20-hiv-protease/",
      "methods": [
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      "human": false,
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    {
      "pmid": "26571560",
      "year": 2015,
      "title": "Anfänge, Entwicklung und Potenzial der Wasserstoffmedizin: Auf dem Weg zu therapeutischen und präventiven Anwendungen von molekularem Wasserstoff gegen eine Vielzahl von Erkrankungen",
      "title_en": "[Initiation, development and potential of hydrogen medicine: Toward therapeutic and preventive applications of molecular hydrogen against a variety of diseases].",
      "title_de": null,
      "journal": "Seikagaku. The Journal of Japanese Biochemical Society",
      "authors": "Ohta",
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      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26571560/",
      "url": "https://h2medizin.org/studien/studie-ohta-2015-anfaenge-entwicklung-potenzial-wasserstoffmedizin/",
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      "human": false,
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    },
    {
      "pmid": "26337845",
      "year": 2015,
      "title": "Direkter Interspezies-Elektronentransfer in der anaeroben Vergärung: Eine Übersichtsarbeit",
      "title_en": "Direct Interspecies Electron Transfer in Anaerobic Digestion: A Review.",
      "title_de": null,
      "journal": "Advances in biochemical engineering/biotechnology",
      "authors": "Dubé et al.",
      "author_search": "dubé dubé",
      "doi": "10.1007/978-3-319-21993-6_4",
      "doi_url": "https://doi.org/10.1007/978-3-319-21993-6_4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26337845/",
      "url": "https://h2medizin.org/studien/studie-dube-2015-direkter-interspezies-elektronentransfer-anaeroben/",
      "methods": [
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      "human": false,
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    },
    {
      "pmid": "25958185",
      "year": 2015,
      "title": "Chemische Kommunikation im Darm: Wirkungen von mikrobiota-erzeugten Metaboliten auf gastrointestinale bakterielle Pathogene.",
      "title_en": "Chemical communication in the gut: Effects of microbiota-generated metabolites on gastrointestinal bacterial pathogens.",
      "title_de": null,
      "journal": "Anaerobe",
      "authors": "Vogt et al.",
      "author_search": "vogt vogt",
      "doi": "10.1016/j.anaerobe.2015.05.002",
      "doi_url": "https://doi.org/10.1016/j.anaerobe.2015.05.002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25958185/",
      "url": "https://h2medizin.org/studien/studie-vogt-2015-chemische-kommunikation-darm-mikrobiota/",
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      "human": false,
      "therapeutic": false,
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    },
    {
      "pmid": "25936365",
      "year": 2015,
      "title": "Molekularer Wasserstoff: Ein inertes Gas wird klinisch wirksam.",
      "title_en": "Molecular hydrogen: An inert gas turns clinically effective.",
      "title_de": null,
      "journal": "Annals of medicine",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.3109/07853890.2015.1034765",
      "doi_url": "https://doi.org/10.3109/07853890.2015.1034765",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25936365/",
      "url": "https://h2medizin.org/studien/studie-ostojic-2015-inertes-wird-klinisch-wirksam/",
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      "human": false,
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    {
      "pmid": "25747486",
      "year": 2015,
      "title": "Molekularer Wasserstoff als neuartiges Antioxidans: Überblick über die Vorteile von Wasserstoff für medizinische Anwendungen.",
      "title_en": "Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications.",
      "title_de": null,
      "journal": "Methods in enzymology",
      "authors": "Ohta",
      "author_search": "ohta ohta",
      "doi": "10.1016/bs.mie.2014.11.038",
      "doi_url": "https://doi.org/10.1016/bs.mie.2014.11.038",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25747486/",
      "url": "https://h2medizin.org/studien/studie-ohta-2015-neuartiges-antioxidans-ueberblick-vorteile/",
      "methods": [
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      "human": false,
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    {
      "pmid": "25720951",
      "year": 2015,
      "title": "Gezielte Ausrichtung von molekularem Wasserstoff an Mitochondrien: Barrieren und Zugangswege.",
      "title_en": "Targeting molecular hydrogen to mitochondria: barriers and gateways.",
      "title_de": null,
      "journal": "Pharmacological research",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1016/j.phrs.2015.02.004",
      "doi_url": "https://doi.org/10.1016/j.phrs.2015.02.004",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25720951/",
      "url": "https://h2medizin.org/studien/studie-ostojic-2015-gezielte-adressierung-mitochondrien-barrieren/",
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      "human": false,
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    {
      "pmid": "25525953",
      "year": 2015,
      "title": "Molekularer Wasserstoff in der Sportmedizin: neue therapeutische Perspektiven.",
      "title_en": "Molecular hydrogen in sports medicine: new therapeutic perspectives.",
      "title_de": null,
      "journal": "International journal of sports medicine",
      "authors": "Ostojic",
      "author_search": "ostojic ostojic",
      "doi": "10.1055/s-0034-1395509",
      "doi_url": "https://doi.org/10.1055/s-0034-1395509",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25525953/",
      "url": "https://h2medizin.org/studien/studie-ostojic-2015-sportmedizin-neue-therapeutische-perspektiven/",
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        "sports-exercise",
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        "oxidative-stress"
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      "evidence_level": 4,
      "human": false,
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    {
      "pmid": "25413928",
      "year": 2015,
      "title": "Strahlenschutz-arbeitsmedizinische Maßnahmen für Strahlenarbeiter als Reaktion auf die komplexe katastrophale Havarie im Kernkraftwerk Fukushima Daiichi.",
      "title_en": "Radiation occupational health interventions offered to radiation workers in response to the complex catastrophic disaster at the Fukushima Daiichi Nuclear Power Plant.",
      "title_de": null,
      "journal": "Journal of radiation research",
      "authors": "Shimura et al.",
      "author_search": "shimura shimura",
      "doi": "10.1093/jrr/rru110",
      "doi_url": "https://doi.org/10.1093/jrr/rru110",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25413928/",
      "url": "https://h2medizin.org/studien/studie-shimura-2015-strahlenschutz-arbeitsmedizinische-massnahmen-strahlenarbeiter/",
      "methods": [
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      "human": false,
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      "h2category": "review"
    },
    {
      "pmid": "24754449",
      "year": 2015,
      "title": "Fortschritte in der Biotechnologie der Wasserstoffproduktion mit der Mikroalge Chlamydomonas reinhardtii.",
      "title_en": "Advances in the biotechnology of hydrogen production with the microalga Chlamydomonas reinhardtii.",
      "title_de": null,
      "journal": "Critical reviews in biotechnology",
      "authors": "Torzillo et al.",
      "author_search": "torzillo torzillo",
      "doi": "10.3109/07388551.2014.900734",
      "doi_url": "https://doi.org/10.3109/07388551.2014.900734",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24754449/",
      "url": "https://h2medizin.org/studien/studie-torzillo-2015-fortschritte-biotechnologie-wasserstoffproduktion-mikroalge/",
      "methods": [
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      "evidence_level": 4,
      "human": false,
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      "h2category": "review"
    },
    {
      "pmid": "26596710",
      "year": 2015,
      "title": "Entdeckung neuartiger chinolinbasierter mTOR-Inhibitoren durch Einführung eines intramolekularen Wasserstoffbrücken-Gerüsts (iMHBS): Design, Synthese und biologische Bewertung.",
      "title_en": "Discovery of novel quinoline-based mTOR inhibitors via introducing intra-molecular hydrogen bonding scaffold (iMHBS): The design, synthesis and biological evaluation.",
      "title_de": null,
      "journal": "Bioorganic & medicinal chemistry",
      "authors": "Ma et al.",
      "author_search": "ma ma",
      "doi": "10.1016/j.bmc.2015.11.003",
      "doi_url": "https://doi.org/10.1016/j.bmc.2015.11.003",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26596710/",
      "url": "https://h2medizin.org/studien/studie-ma-2015-entdeckung-neuartiger-chinolinbasierter-mtor/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26271894",
      "year": 2015,
      "title": "Wasserstoffreiches Wasser mildert die durch Amyloid-β induzierte Zytotoxizität durch Hochregulation von Sirt1-FoxO3a über die Stimulation der AMP-aktivierten Proteinkinase in SK-N-MC-Zellen.",
      "title_en": "Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells.",
      "title_de": null,
      "journal": "Chemico-biological interactions",
      "authors": "Lin et al.",
      "author_search": "lin lin",
      "doi": "10.1016/j.cbi.2015.07.013",
      "doi_url": "https://doi.org/10.1016/j.cbi.2015.07.013",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26271894/",
      "url": "https://h2medizin.org/studien/studie-lin-2015-mildert-amyloid-induzierte-zytotoxizitaet/",
      "methods": [
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    {
      "pmid": "26253656",
      "year": 2015,
      "title": "Molekularer Wasserstoff schützt Mäuse vor polymikrobieller Sepsis durch Milderung der Endotheldysfunktion über einen Nrf2/HO-1-Signalweg.",
      "title_en": "Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway.",
      "title_de": null,
      "journal": "International immunopharmacology",
      "authors": "Chen et al.",
      "author_search": "chen chen",
      "doi": "10.1016/j.intimp.2015.07.034",
      "doi_url": "https://doi.org/10.1016/j.intimp.2015.07.034",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26253656/",
      "url": "https://h2medizin.org/studien/studie-chen-2015-schuetzt-maeuse-vor-polymikrobieller/",
      "methods": [
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      "indications": [
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        "cancer",
        "respiratory",
        "immune-system"
      ],
      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "26125821",
      "year": 2015,
      "title": "Schützende Wirkungen von wasserstoffreichem Medium auf die lipopolysaccharid-induzierte monozytäre Adhäsion und die Permeabilität des Gefäßendothels durch Regulation des vaskulären endothelialen Cadherins.",
      "title_en": "Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin.",
      "title_de": null,
      "journal": "Genetics and molecular research : GMR",
      "authors": "Yu et al.",
      "author_search": "yu yu",
      "doi": "10.4238/2015.june.9.6",
      "doi_url": "https://doi.org/10.4238/2015.june.9.6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26125821/",
      "url": "https://h2medizin.org/studien/studie-yu-2015-schuetzende-wasserstoffreichem-medium-lipopolysaccharid/",
      "methods": [
        "unspecified"
      ],
      "indications": [
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        "joints-rheumatology"
      ],
      "evidence_level": 1,
      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "26117323",
      "year": 2015,
      "title": "Molekularer Wasserstoff stabilisiert atherosklerotische Plaque in Low-Density-Lipoprotein-Rezeptor-Knockout-Mäusen.",
      "title_en": "Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.",
      "title_de": null,
      "journal": "Free radical biology & medicine",
      "authors": "Song et al.",
      "author_search": "song song",
      "doi": "10.1016/j.freeradbiomed.2015.06.018",
      "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2015.06.018",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26117323/",
      "url": "https://h2medizin.org/studien/studie-song-2015-stabilisiert-atherosklerotische-plaque-low/",
      "methods": [
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      ],
      "indications": [
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        "cardiovascular",
        "oxidative-stress"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26077945",
      "year": 2015,
      "title": "Wirkung der T68A/N126Y-Mutationen auf die Konformations- und Ligandenbindungslandschaft der Coxsackievirus-B3-3C-Protease.",
      "title_en": "Effect of T68A/N126Y mutations on the conformational and ligand binding landscape of Coxsackievirus B3 3C protease.",
      "title_de": null,
      "journal": "Molecular bioSystems",
      "authors": "Bhakat",
      "author_search": "bhakat bhakat",
      "doi": "10.1039/c5mb00262a",
      "doi_url": "https://doi.org/10.1039/c5mb00262a",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/26077945/",
      "url": "https://h2medizin.org/studien/studie-bhakat-2015-t68a-n126y-mutationen-konformations/",
      "methods": [
        "unspecified"
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      "indications": [
        "other"
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "26028929",
      "year": 2015,
      "title": "Bestimmung der Rifaximin-Behandlungsdauer anhand von Laktulose-Atemtestwerten bei nicht-obstipierten Reizdarmsyndrom-Probanden.",
      "title_en": "Determination of rifaximin treatment period according to lactulose breath test values in nonconstipated irritable bowel syndrome subjects.",
      "title_de": null,
      "journal": "Journal of Korean medical science",
      "authors": "Bae et al.",
      "author_search": "bae bae",
      "doi": "10.3346/jkms.2015.30.6.757",
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      "title_en": "Atomic Insight into the Altered O6-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric Cancer.",
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      "title": "Michael-Akzeptor in Gambogasäure — seine Rolle und Anwendung für potente Antitumor-Wirkstoffe.",
      "title_en": "Michael acceptor in gambogic acid--Its role and application for potent antitumor agents.",
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      "title_en": "Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury.",
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      "title": "Verbesserung der psoriasis-assoziierten Arthritis und Hautläsionen durch Behandlung mit molekularem Wasserstoff: Ein Bericht über drei Fälle.",
      "title_en": "Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.",
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      "title": "Eumelanin-gesteuerte Produktion von molekularem Wasserstoff: ein neues Element der Hautabwehr?",
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      "title": "Wasserstoffreiches Medium schwächte die Lipopolysaccharid-induzierte Monozyten-Endothelzell-Adhäsion und die vaskuläre Endothelpermeabilität über die Rho-assoziierte Coiled-Coil-Proteinkinase ab.",
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      "title": "[Alpha-Glucosidase-Hemmer]. (Nihon Rinsho)",
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      "title": "Wasserstofftherapie reduziert mit oxidativem Stress assoziierte Risiken nach akuter und chronischer Exposition gegenüber einer Höhenumgebung.",
      "title_en": "Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment.",
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      "authors": "Shi et al.",
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      "title": "Synthese, spektrale Charakterisierung, thermisches Verhalten, antibakterielle Aktivität und DFT-Berechnung an N'-[Bis(methylsulfanyl)methylen]-2-hydroxybenzohydrazid und N'-(4-Methoxybenzoyl)-hydrazincarbodithionsäure-ethylester.",
      "title_en": "Synthesis, spectral characterization, thermal behaviour, antibacterial activity and DFT calculation on N'-[bis(methylsulfanyl) methylene]-2-hydroxybenzohydrazide and N'-(4-methoxy benzoyl)-hydrazinecarbodithioic acid ethyl ester.",
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      "title": "Vorhersage der Bindungsmodi zwischen Protein-L-Isoaspartyl-(D-Aspartyl)-O-Methyltransferase und Peptidsubstraten mit isomerisierten Asparaginsäureresten unter Verwendung von In-silico-Analysemethoden für das Substrat-Screening.",
      "title_en": "Prediction of binding modes between protein L-isoaspartyl (D-aspartyl) O-methyltransferase and peptide substrates including isomerized aspartic acid residues using in silico analytic methods for the substrate screening.",
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      "title": "Diversität von mit dem Menschen assoziierten Methanobrevibacter-smithii-Isolaten, aufgedeckt durch Multispacer-Sequenztypisierung.",
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      "title": "Kann ein harmloses Spielzeug gefährlich werden? Die Wasserstoffgasballon-Verbrennung.",
      "title_en": "Can an innocent toy become dangerous? The hydrogen gas balloon burn.",
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      "title": "Die Verwendung der Wasserstoffgas-Clearance zur Messung des Blutflusses in einzelnen endogenen und transplantierten Pankreasinseln.",
      "title_en": "The use of hydrogen gas clearance for blood flow measurements in single endogenous and transplanted pancreatic islets.",
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      "title": "Campylobacter-concisus-Pseudoausbruch verursacht durch verbesserte Kulturbedingungen.",
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      "pmid": "24829918",
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      "title": "Wasserstoffgas stellt eine vielversprechende therapeutische Strategie für Sepsis dar.",
      "title_en": "Hydrogen gas presents a promising therapeutic strategy for sepsis.",
      "title_de": null,
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      "title": "Molekularer Wasserstoff als präventives und therapeutisches medizinisches Gas: Beginn, Entwicklung und Potenzial der Wasserstoffmedizin.",
      "title_en": "Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.",
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      "title": "Neuartige therapeutische Strategien für das Schädel-Hirn-Trauma: akute antioxidative Verstärkung.",
      "title_en": "Novel therapeutic strategies for traumatic brain injury: acute antioxidant reinforcement.",
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      "pmid": "25378931",
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      "title": "Der Konsum von Wasser mit mehr als 3,5 mg gelöstem Wasserstoff könnte die vaskuläre Endothelfunktion verbessern.",
      "title_en": "Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function.",
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      "title": "Wirksamkeit von oralem und topischem Wasserstoff bei sportbedingten Weichteilverletzungen.",
      "title_en": "Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries.",
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      "pmid": "25201463",
      "year": 2014,
      "title": "Wirkungen der intravenösen Infusion von wasserstoffreicher Flüssigkeit kombiniert mit intrazisternaler Infusion von Magnesiumsulfat bei schwerer aneurysmatischer Subarachnoidalblutung: Studienprotokoll für eine randomisierte kontrollierte Studie.",
      "title_en": "Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial.",
      "title_de": null,
      "journal": "BMC neurology",
      "authors": "Takeuchi et al.",
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      "doi": "10.1186/s12883-014-0176-1",
      "doi_url": "https://doi.org/10.1186/s12883-014-0176-1",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/25201463/",
      "url": "https://h2medizin.org/studien/studie-takeuchi-2014-intravenoesen-infusion-wasserstoffreicher-fluessigkeit/",
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    },
    {
      "pmid": "24929023",
      "year": 2014,
      "title": "Therapeutische Wirksamkeit von in Kochsalzlösung infundiertem molekularem Wasserstoff bei rheumatoider Arthritis: eine randomisierte, doppelblinde, placebokontrollierte Pilotstudie.",
      "title_en": "Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.",
      "title_de": null,
      "journal": "International immunopharmacology",
      "authors": "Ishibashi et al.",
      "author_search": "ishibashi ishibashi",
      "doi": "10.1016/j.intimp.2014.06.001",
      "doi_url": "https://doi.org/10.1016/j.intimp.2014.06.001",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24929023/",
      "url": "https://h2medizin.org/studien/studie-ishibashi-2014-therapeutische-kochsalzloesung-infundiertem-rheumatoider/",
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    },
    {
      "pmid": "25942929",
      "year": 2014,
      "title": "Polymerverkapselung von Magnesium zur Steuerung von Biologisch-Abbaubarkeit und Biokompatibilität.",
      "title_en": "Polymer encapsulation of magnesium to control biodegradability and biocompatibility.",
      "title_de": null,
      "journal": "Journal of nanoscience and nanotechnology",
      "authors": "Bazaka et al.",
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      "doi": "10.1166/jnn.2014.9409",
      "doi_url": "https://doi.org/10.1166/jnn.2014.9409",
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      "url": "https://h2medizin.org/studien/studie-bazaka-2014-polymerverkapselung-magnesium-zur-steuerung/",
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    },
    {
      "pmid": "24890090",
      "year": 2014,
      "title": "Thiazolidin-2,4-dion-Derivate als PPAR-γ-Agonisten: Synthese, molekulares Docking, antidiabetische Aktivität in vitro und in vivo mit Bewertung des Hepatotoxizitätsrisikos.",
      "title_en": "Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression.",
      "title_de": null,
      "journal": "Bioorganic & medicinal chemistry letters",
      "authors": "Nazreen et al.",
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      "doi": "10.1016/j.bmcl.2014.05.034",
      "doi_url": "https://doi.org/10.1016/j.bmcl.2014.05.034",
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      "url": "https://h2medizin.org/studien/studie-nazreen-2014-thiazolidin-dion-derivate-ppar/",
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    },
    {
      "pmid": "24793096",
      "year": 2014,
      "title": "Wirkung von wasserstoffreichem Wasser auf akute Peritonitis in Rattenmodellen.",
      "title_en": "Effect of hydrogen-rich water on acute peritonitis of rat models.",
      "title_de": null,
      "journal": "International immunopharmacology",
      "authors": "Zhang et al.",
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      "doi": "10.1016/j.intimp.2014.04.011",
      "doi_url": "https://doi.org/10.1016/j.intimp.2014.04.011",
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      "url": "https://h2medizin.org/studien/studie-zhang-2014-wasserstoffreichem-akute-peritonitis-rattenmodellen/",
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    {
      "pmid": "24694477",
      "year": 2014,
      "title": "Können Alpha-Glucosidase-Hemmer portalvenöses Gas induzieren? – Zwei klinische Fallberichte.",
      "title_en": "Do alpha-glucosidase inhibitors have the potential to induce portal venous gas? -Two clinical case reports.",
      "title_de": null,
      "journal": "Internal medicine (Tokyo, Japan)",
      "authors": "Makiyama et al.",
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      "doi": "10.2169/internalmedicine.53.1789",
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    {
      "pmid": "24529916",
      "year": 2014,
      "title": "Die Parkinson-Krankheit könnte auf das Versagen von Melanin in der Substantia nigra zurückzuführen sein, molekularen Wasserstoff aus der Dissoziation von Wasser zu produzieren.",
      "title_en": "Parkinson's disease may be due to failure of melanin in the Substantia Nigra to produce molecular hydrogen from dissociation of water, to protect the brain from oxidative stress.",
      "title_de": null,
      "journal": "Medical hypotheses",
      "authors": "Brenner",
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      "doi": "10.1016/j.mehy.2014.01.013",
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    {
      "pmid": "24509162",
      "year": 2014,
      "title": "Mütterliche Verabreichung von molekularem Wasserstoff lindert den durch intrauterine Ischämie-Reperfusion verursachten Schaden am fetalen Hippocampus der Ratte.",
      "title_en": "Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.",
      "title_de": null,
      "journal": "Free radical biology & medicine",
      "authors": "Mano et al.",
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      "doi": "10.1016/j.freeradbiomed.2014.01.037",
      "doi_url": "https://doi.org/10.1016/j.freeradbiomed.2014.01.037",
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      "url": "https://h2medizin.org/studien/studie-mano-2014-muetterliche-verabreichung-lindert-den/",
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    {
      "pmid": "24491676",
      "year": 2014,
      "title": "Clusianon, ein natürlich vorkommendes Nemoroson-Regioisomer, entkoppelt Rattenleber-Mitochondrien und induziert den Zelltod von HepG2-Zellen.",
      "title_en": "Clusianone, a naturally occurring nemorosone regioisomer, uncouples rat liver mitochondria and induces HepG2 cell death.",
      "title_de": null,
      "journal": "Chemico-biological interactions",
      "authors": "Reis et al.",
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      "doi_url": "https://doi.org/10.1016/j.cbi.2014.01.015",
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      "url": "https://h2medizin.org/studien/studie-reis-2014-clusianon-natuerlich-vorkommendes-nemoroson/",
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    {
      "pmid": "24392771",
      "year": 2014,
      "title": "Wasserstoffreiches Wasser beeinflusste die Blutalkalität bei körperlich aktiven Männern.",
      "title_en": "Hydrogen-rich water affected blood alkalinity in physically active men.",
      "title_de": null,
      "journal": "Research in sports medicine (Print)",
      "authors": "Ostojic et al.",
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      "doi": "10.1080/15438627.2013.852092",
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      "url": "https://h2medizin.org/studien/studie-ostojic-2014-beeinflusste-blutalkalitaet-koerperlich-aktiven/",
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    {
      "pmid": "24291328",
      "year": 2014,
      "title": "Steuerung der initialen Biodegradation von Magnesium durch eine biokompatible Strontiumphosphat-Konversionsbeschichtung",
      "title_en": "Controlling initial biodegradation of magnesium by a biocompatible strontium phosphate conversion coating.",
      "title_de": null,
      "journal": "Acta biomaterialia",
      "authors": "Chen et al.",
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      "doi": "10.1016/j.actbio.2013.11.016",
      "doi_url": "https://doi.org/10.1016/j.actbio.2013.11.016",
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    {
      "pmid": "24068473",
      "year": 2014,
      "title": "DNA-Bindungsstudien und Antitumor-Bewertung neuartiger wasserlöslicher organischer pip- und hpip-Analoga",
      "title_en": "DNA-binding studies and antitumor evaluation of novel water soluble organic pip and hpip analogs.",
      "title_de": null,
      "journal": "Applied biochemistry and biotechnology",
      "authors": "Coban et al.",
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      "doi": "10.1007/s12010-013-0513-7",
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    {
      "pmid": "24697097",
      "year": 2013,
      "title": "Equol: ein Metabolit von Soja-Isoflavonen durch die Darmflora — eine Übersichtsarbeit",
      "title_en": "[Equol: a metabolite of soy isoflavones by intestinal microflora--a review].",
      "title_de": null,
      "journal": "Wei sheng wu xue bao = Acta microbiologica Sinica",
      "authors": "Zheng et al.",
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      "doi": null,
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      "url": "https://h2medizin.org/studien/studie-zheng-2013-equol-metabolit-soja-isoflavonen/",
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    {
      "pmid": "24358804",
      "year": 2013,
      "title": "Betrachtung des Oxidantien-/Antioxidantien-Ungleichgewichts im Innenohr",
      "title_en": "[Introspection of oxidant/antioxidant imbalance in the inner ear].",
      "title_de": null,
      "journal": "Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery",
      "authors": "Wang et al.",
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      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24358804/",
      "url": "https://h2medizin.org/studien/studie-wang-2013-betrachtung-des-oxidantien-antioxidantien/",
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    {
      "pmid": "24155664",
      "year": 2013,
      "title": "Wasserstoff als eine neue Klasse von Radioprotektoren",
      "title_en": "Hydrogen as a new class of radioprotective agent.",
      "title_de": null,
      "journal": "International journal of biological sciences",
      "authors": "Qian et al.",
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      "doi": "10.7150/ijbs.7220",
      "doi_url": "https://doi.org/10.7150/ijbs.7220",
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    {
      "pmid": "24132155",
      "year": 2013,
      "title": "Multiple Schädigungen, einschließlich oxidativem Stress, als Pathogenese und Behandlungsziel bei der nichtalkoholischen Steatohepatitis (NASH)",
      "title_en": "Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH).",
      "title_de": null,
      "journal": "International journal of molecular sciences",
      "authors": "Takaki et al.",
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      "doi": "10.3390/ijms141020704",
      "doi_url": "https://doi.org/10.3390/ijms141020704",
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      "url": "https://h2medizin.org/studien/studie-takaki-2013-multiple-schaedigungen-einschliesslich-oxidativem/",
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    {
      "pmid": "23921897",
      "year": 2013,
      "title": "Warum bevorzugt der Gehirnstoffwechsel nicht die Verbrennung von Fettsäuren zur Energiegewinnung? Überlegungen zu den Nachteilen der Verwendung freier Fettsäuren als Brennstoff für das Gehirn",
      "title_en": "Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain.",
      "title_de": null,
      "journal": "Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism",
      "authors": "Schönfeld et al.",
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      "doi": "10.1038/jcbfm.2013.128",
      "doi_url": "https://doi.org/10.1038/jcbfm.2013.128",
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      "url": "https://h2medizin.org/studien/studie-schoenfeld-2013-warum-bevorzugt-gehirnstoffwechsel-nicht/",
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    {
      "pmid": "23859555",
      "year": 2013,
      "title": "Molekularer Wasserstoff: neue antioxidative und antiinflammatorische Therapie für rheumatoide Arthritis und verwandte Erkrankungen",
      "title_en": "Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases.",
      "title_de": null,
      "journal": "Current pharmaceutical design",
      "authors": "Ishibashi",
      "author_search": "ishibashi ishibashi",
      "doi": "10.2174/13816128113199990507",
      "doi_url": "https://doi.org/10.2174/13816128113199990507",
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      "url": "https://h2medizin.org/studien/studie-ishibashi-2013-neue-antioxidative-antiinflammatorische-rheumatoide/",
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    {
      "pmid": "23436141",
      "year": 2013,
      "title": "Rolle des Toll-Like-Rezeptor-(TLR-)Radikalzyklus bei chronischer Entzündung: mögliche Behandlungen mit Zielrichtung auf den TLR4-Signalweg",
      "title_en": "Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway.",
      "title_de": null,
      "journal": "Molecular neurobiology",
      "authors": "Lucas et al.",
      "author_search": "lucas lucas",
      "doi": "10.1007/s12035-013-8425-7",
      "doi_url": "https://doi.org/10.1007/s12035-013-8425-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23436141/",
      "url": "https://h2medizin.org/studien/studie-lucas-2013-rolle-des-toll-like/",
      "methods": [
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    {
      "pmid": "24127924",
      "year": 2013,
      "title": "Wirkung von wasserstoffreichem Wasser auf oxidativen Stress, Leberfunktion und Viruslast bei Patienten mit chronischer Hepatitis B.",
      "title_en": "Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.",
      "title_de": null,
      "journal": "Clinical and translational science",
      "authors": "Xia et al.",
      "author_search": "xia xia",
      "doi": "10.1111/cts.12076",
      "doi_url": "https://doi.org/10.1111/cts.12076",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/24127924/",
      "url": "https://h2medizin.org/studien/studie-xia-2013-wasserstoffreichem-oxidativen-stress-leberfunktion/",
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    {
      "pmid": "23400965",
      "year": 2013,
      "title": "Pilotstudie zur H₂-Therapie bei der Parkinson-Krankheit: eine randomisierte, doppelblinde, placebokontrollierte Studie.",
      "title_en": "Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.",
      "title_de": null,
      "journal": "Movement disorders : official journal of the Movement Disorder Society",
      "authors": "Yoritaka et al.",
      "author_search": "yoritaka yoritaka",
      "doi": "10.1002/mds.25375",
      "doi_url": "https://doi.org/10.1002/mds.25375",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23400965/",
      "url": "https://h2medizin.org/studien/studie-yoritaka-2013-pilotstudie-zur-parkinson-krankheit/",
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    {
      "pmid": "23374763",
      "year": 2013,
      "title": "Wirkung der Supplementierung mit wasserstoffreichem Wasser bei Patienten mit interstitieller Zystitis/Blasenschmerzsyndrom.",
      "title_en": "Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.",
      "title_de": null,
      "journal": "Urology",
      "authors": "Matsumoto et al.",
      "author_search": "matsumoto matsumoto",
      "doi": "10.1016/j.urology.2012.10.026",
      "doi_url": "https://doi.org/10.1016/j.urology.2012.10.026",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/23374763/",
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    {
      "pmid": "24423914",
      "year": 2013,
      "title": "Regulierende Wirkungen von wasserstoffreichem Medium auf die monozytäre Adhäsion und die vaskuläre Endothelpermeabilität",
      "title_en": "[Regulative effects of hydrogen-rich medium on monocytic adhesion and vascular endothelial permeability].",
      "title_de": null,
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    {
      "pmid": "24001618",
      "year": 2013,
      "title": "Ein nichtwässriges Reduktionsverfahren zur Aufreinigung von ¹⁵³Gd, das in natürlichen Europium-Targets erzeugt wird",
      "title_en": "A non-aqueous reduction process for purifying ¹⁵³Gd produced in natural europium targets.",
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      "journal": "Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine",
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      "year": 2013,
      "title": "Eine In-silico-Analyse von Troponin-I-Mutationen bei hypertropher Kardiomyopathie indischer Herkunft",
      "title_en": "An in silico analysis of troponin I mutations in hypertrophic cardiomyopathy of Indian origin.",
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    {
      "pmid": "23871246",
      "year": 2013,
      "title": "Wasserstoffreiche Kochsalzlösung lindert die durch einseitige Ureterobstruktion induzierte Nierenschädigung bei Ratten.",
      "title_en": "Hydrogen-rich saline ameliorates renal injury induced by unilateral ureteral obstruction in rats.",
      "title_de": null,
      "journal": "International immunopharmacology",
      "authors": "Xu et al.",
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      "doi": "10.1016/j.intimp.2013.06.033",
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    {
      "pmid": "23852510",
      "year": 2013,
      "title": "Verbrauch von molekularem Wasserstoff im menschlichen Körper während der Inhalation von Wasserstoffgas.",
      "title_en": "Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas.",
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      "journal": "Advances in experimental medicine and biology",
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      "year": 2013,
      "title": "Molekularer Wasserstoff schützt menschliche AHH-1-Lymphozytenzellen vor ¹²C⁶⁺-Schwerionenstrahlung.",
      "title_en": "Molecular hydrogen protects human lymphocyte AHH-1 cells against 12C6+ heavy ion radiation.",
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      "journal": "International journal of radiation biology",
      "authors": "Yang et al.",
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      "doi": "10.3109/09553002.2013.817704",
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      "url": "https://h2medizin.org/studien/studie-yang-2013-schuetzt-menschliche-ahh-lymphozytenzellen/",
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    {
      "pmid": "23610159",
      "year": 2013,
      "title": "Wasserstoffreiches Wasser senkt die Serum-LDL-Cholesterinspiegel und verbessert die HDL-Funktion bei Patienten mit potenziellem metabolischem Syndrom.",
      "title_en": "Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.",
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      "journal": "Journal of lipid research",
      "authors": "Song et al.",
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      "doi": "10.1194/jlr.m036640",
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    {
      "pmid": "23467041",
      "year": 2013,
      "title": "Oberflächenerodierende PTMC-Beschichtung für vollständig biologisch abbaubare magnesiumbasierte Stent-Anwendungen.",
      "title_en": "A surface-eroding poly(1,3-trimethylene carbonate) coating for fully biodegradable magnesium-based stent applications: toward better biofunction, biodegradation and biocompatibility.",
      "title_de": null,
      "journal": "Acta biomaterialia",
      "authors": "Wang et al.",
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      "url": "https://h2medizin.org/studien/studie-wang-2013-oberflaechenerodierende-poly-trimethylencarbonat-beschichtung/",
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    {
      "pmid": "23457571",
      "year": 2013,
      "title": "Lösungsmittelschutz von Amidprotonen in Amylin-Fibrillen, untersucht mittels gequenchter Wasserstoffaustausch-NMR.",
      "title_en": "Amide proton solvent protection in amylin fibrils probed by quenched hydrogen exchange NMR.",
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    {
      "pmid": "22537465",
      "year": 2012,
      "title": "Molekularer Wasserstoff und Strahlenschutz",
      "title_en": "Molecular hydrogen and radiation protection",
      "title_de": null,
      "journal": "Free Radical Research",
      "authors": "Chuai et al.",
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      "doi": "10.3109/10715762.2012.689429",
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    {
      "pmid": "22965001",
      "year": 2012,
      "title": "Protonenreduktion zu Wasserstoff in biologischen und chemischen Systemen.",
      "title_en": "Proton reduction to hydrogen in biological and chemical systems.",
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      "journal": "Physical chemistry chemical physics : PCCP",
      "authors": "Tran et al.",
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      "doi": "10.1039/c2cp42413d",
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    {
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      "year": 2012,
      "title": "Molekularer Wasserstoff als aufkommendes therapeutisches medizinisches Gas für neurodegenerative und andere Erkrankungen.",
      "title_en": "Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.",
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      "journal": "Oxidative medicine and cellular longevity",
      "authors": "Ohno et al.",
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      "doi": "10.1155/2012/353152",
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    {
      "pmid": "22585131",
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      "title": "Beiträge des mikrobiellen Wasserstoffhaushalts zur kolischen Homöostase.",
      "title_en": "Contributions of the microbial hydrogen economy to colonic homeostasis.",
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      "authors": "Carbonero et al.",
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      "doi": "10.1038/nrgastro.2012.85",
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    {
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      "title": "Molekularer Wasserstoff ist ein neuartiges Antioxidans zur effizienten Reduktion von oxidativem Stress mit Potenzial für die Verbesserung mitochondrialer Erkrankungen.",
      "title_en": "Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.",
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      "doi": "10.1016/j.bbagen.2011.05.006",
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    {
      "pmid": "23079742",
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      "title": "Bindungs-Hotspots in einer Antikörper-ssDNA-Grenzfläche: eine molekulardynamische Studie.",
      "title_en": "Binding hot-spots in an antibody-ssDNA interface: a molecular dynamics study.",
      "title_de": null,
      "journal": "Molecular bioSystems",
      "authors": "Wang et al.",
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      "doi": "10.1039/c2mb25250c",
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    {
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      "year": 2012,
      "title": "Eine Wasserstoffgas-Wasser-Äquilibrierungsmethode liefert genaue und präzise Messungen stabiler Wasserstoff-Isotopenverhältnisse in Ernährungsstudien.",
      "title_en": "A hydrogen gas-water equilibration method produces accurate and precise stable hydrogen isotope ratio measurements in nutrition studies.",
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      "journal": "The Journal of nutrition",
      "authors": "Wong et al.",
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      "doi": "10.3945/jn.112.167957",
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    {
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      "year": 2012,
      "title": "Nachweis der Erhaltung nativer inter- und intramolekularer Wasserstoffbrückenbindungen im desolvatisierten FK-Bindungsprotein·FK506-Komplex, erzeugt durch Elektrospray-Ionisation.",
      "title_en": "Evidence for the preservation of native inter- and intra-molecular hydrogen bonds in the desolvated FK-binding protein·FK506 complex produced by electrospray ionization.",
      "title_de": null,
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      "title": "Wasserstoff könnte die kollageninduzierte Thrombozytenaggregation hemmen: eine Ex-vivo- und In-vivo-Studie.",
      "title_en": "Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study.",
      "title_de": null,
      "journal": "Internal medicine (Tokyo, Japan)",
      "authors": "Takeuchi et al.",
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      "doi": "10.2169/internalmedicine.51.7161",
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      "url": "https://h2medizin.org/studien/studie-takeuchi-2012-koennte-kollageninduzierte-thrombozytenaggregation-hemmen/",
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    {
      "pmid": "22648259",
      "year": 2012,
      "title": "Die Wasserstofftherapie könnte eine wirksame und spezifische neuartige Behandlung für aplastische Anämie sein.",
      "title_en": "Hydrogen therapy may be an effective and specific novel treatment for aplastic anemia.",
      "title_de": null,
      "journal": "Medical science monitor : international medical journal of experimental and clinical research",
      "authors": "Qian et al.",
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      "doi": "10.12659/msm.882886",
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      "url": "https://h2medizin.org/studien/studie-qian-2012-wasserstofftherapie-koennte-wirksame-spezifische/",
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    {
      "pmid": "22560529",
      "year": 2012,
      "title": "Serumalkalisierung und wasserstoffreiches Wasser bei gesunden Männern.",
      "title_en": "Serum alkalinization and hydrogen-rich water in healthy men.",
      "title_de": null,
      "journal": "Mayo Clinic proceedings",
      "authors": "Ostojic",
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      "doi": "10.1016/j.mayocp.2012.02.008",
      "doi_url": "https://doi.org/10.1016/j.mayocp.2012.02.008",
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      "url": "https://h2medizin.org/studien/studie-ostojic-2012-serumalkalisierung-gesunden-maennern/",
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    {
      "pmid": "22460088",
      "year": 2012,
      "title": "Wasserstoffreiche Kochsalzlösung schützt Immunzellen vor strahlungsinduzierter Apoptose.",
      "title_en": "Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.",
      "title_de": null,
      "journal": "Medical science monitor : international medical journal of experimental and clinical research",
      "authors": "Yang et al.",
      "author_search": "yang yang",
      "doi": "10.12659/msm.882616",
      "doi_url": "https://doi.org/10.12659/msm.882616",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22460088/",
      "url": "https://h2medizin.org/studien/studie-yang-2012-wasserstoffreiche-kochsalzloesung-schuetzt-immunzellen/",
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    {
      "pmid": "22431222",
      "year": 2012,
      "title": "Ladungsstellenabhängige Dissoziation wasserstoffreicher Radikal-Peptidkationen bei Vakuum-UV-Photoanregung.",
      "title_en": "Charge-site-dependent dissociation of hydrogen-rich radical peptide cations upon vacuum UV photoexcitation.",
      "title_de": null,
      "journal": "Chemistry (Weinheim an der Bergstrasse, Germany)",
      "authors": "Madsen et al.",
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      "doi": "10.1002/chem.201103534",
      "doi_url": "https://doi.org/10.1002/chem.201103534",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/22431222/",
      "url": "https://h2medizin.org/studien/studie-madsen-2012-ladungsstellenabhaengige-dissoziation-wasserstoffreicher-radikal/",
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    {
      "pmid": "22425564",
      "year": 2012,
      "title": "Hemmung des NS5A-Proteins des Hepatitis-C-Virus durch Fluor-Olefin-basierte γ-Turn-Mimetika.",
      "title_en": "Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics.",
      "title_de": null,
      "journal": "Bioorganic & medicinal chemistry letters",
      "authors": "Chang et al.",
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      "doi_url": "https://doi.org/10.1016/j.bmcl.2012.02.051",
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    {
      "pmid": "22390199",
      "year": 2012,
      "title": "Hydrogenase: das nächste Antibiotika-Ziel?",
      "title_en": "Hydrogenase: the next antibiotic target?",
      "title_de": null,
      "journal": "Clinical science (London, England : 1979)",
      "authors": "Nie et al.",
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      "doi": "10.1042/cs20110396",
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    {
      "pmid": "22339382",
      "year": 2012,
      "title": "Bewertung von Ausgasung, Reißfestigkeit und Detailwiedergabe in Alginat-Ersatzmaterialien.",
      "title_en": "Evaluation of outgassing, tear strength, and detail reproduction in alginate substitute materials.",
      "title_de": null,
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      "authors": "Baxter et al.",
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      "doi": "10.2341/11-365-l",
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    {
      "pmid": "22287575",
      "year": 2012,
      "title": "Die orale Aufnahme von wasserstoffreichem Wasser hemmt die Intimahyperplasie in arterialisierten Venentransplantaten bei Ratten.",
      "title_en": "Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.",
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      "authors": "Sun et al.",
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      "doi": "10.1093/cvr/cvs024",
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    {
      "pmid": "22259109",
      "year": 2012,
      "title": "Schätzung des Verbrauchs von molekularem Wasserstoff im gesamten menschlichen Körper nach der Aufnahme von wasserstoffreichem Wasser",
      "title_en": "Estimation of molecular hydrogen consumption in the human whole body after the ingestion of hydrogen-rich water.",
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      "journal": "Advances in experimental medicine and biology",
      "authors": "Shimouchi et al.",
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    {
      "pmid": "22070900",
      "year": 2012,
      "title": "Wasserstoffreiches elektrolysiertes warmes Wasser unterdrückt die Faltenbildung gegen UVA-Strahlen zusammen mit der Typ-I-Kollagenproduktion und der Verringerung von oxidativem Stress in Fibroblasten sowie der Verhinderung von Zellschäden in Keratinozyten.",
      "title_en": "Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.",
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      "journal": "Journal of photochemistry and photobiology. B, Biology",
      "authors": "Kato et al.",
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      "doi": "10.1016/j.jphotobiol.2011.09.006",
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    {
      "pmid": "21736547",
      "year": 2011,
      "title": "Jüngste Fortschritte in Richtung Wasserstoffmedizin: Potenzial von molekularem Wasserstoff für präventive und therapeutische Anwendungen.",
      "title_en": "Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.",
      "title_de": null,
      "journal": "Current pharmaceutical design",
      "authors": "Ohta",
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      "doi": "10.2174/138161211797052664",
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    {
      "pmid": "21736540",
      "year": 2011,
      "title": "Das Prinzip und der mögliche Ansatz zur ROS-abhängigen Zytotoxizität durch nichtpharmazeutische Therapien: optimale Nutzung medizinischer Gase mit antioxidativen Eigenschaften.",
      "title_en": "The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: optimal use of medical gases with antioxidant properties.",
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      "journal": "Current pharmaceutical design",
      "authors": "Noda et al.",
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    {
      "pmid": "21573992",
      "year": 2011,
      "title": "Fehlerhafte Proteinfaltung und Aggregation als Grundlage neurodegenerativer Erkrankungen: der dunklere Aspekt von Proteinen.",
      "title_en": "Defective protein folding and aggregation as the basis of neurodegenerative diseases: the darker aspect of proteins.",
      "title_de": null,
      "journal": "Cell biochemistry and biophysics",
      "authors": "Naeem et al.",
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    {
      "pmid": "21562446",
      "year": 2011,
      "title": "Machbarkeit der Messung der menschlichen Pankreasperfusion in vivo mittels bildgebender Verfahren",
      "title_en": "Feasibility of measuring human pancreatic perfusion in vivo using imaging techniques.",
      "title_de": null,
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    {
      "pmid": "21251046",
      "year": 2011,
      "title": "Wasserstoff-Reanimation, ein neuer zytoprotektiver Ansatz.",
      "title_en": "Hydrogen resuscitation, a new cytoprotective approach.",
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      "authors": "Zheng et al.",
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    {
      "pmid": "21244359",
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      "title": "Melatonin-Mitochondrien-Wechselspiel in Gesundheit und Krankheit",
      "title_en": "Melatonin-mitochondria interplay in health and disease.",
      "title_de": null,
      "journal": "Current topics in medicinal chemistry",
      "authors": "Acuña Castroviejo et al.",
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      "doi": "10.2174/156802611794863517",
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    {
      "pmid": "22417501",
      "year": 2011,
      "title": "Verdaulichkeit, Fermentierbarkeit und Energiewert von hochgradig quervernetzter Phosphat-Tapiokastärke bei Männern",
      "title_en": "Digestibility, fermentability, and energy value of highly cross-linked phosphate tapioca starch in men.",
      "title_de": null,
      "journal": "Journal of food science",
      "authors": "Tachibe et al.",
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      "pmid": "22079833",
      "year": 2011,
      "title": "Das Hydrogenosom-Proteom von Trichomonas vaginalis ist im Vergleich zu Mitochondrien stark reduziert, jedoch komplex im Vergleich zu Mitosomen",
      "title_en": "The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes.",
      "title_de": null,
      "journal": "International journal for parasitology",
      "authors": "Schneider et al.",
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      "doi_url": "https://doi.org/10.1016/j.ijpara.2011.10.001",
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      "url": "https://h2medizin.org/studien/studie-schneider-2011-hydrogenosom-proteom-trichomonas-vaginalis/",
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    {
      "pmid": "21859325",
      "year": 2011,
      "title": "Variation in den Schätzungen der lunaren Neutronendosis",
      "title_en": "Variation in lunar neutron dose estimates.",
      "title_de": null,
      "journal": "Radiation research",
      "authors": "Slaba et al.",
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      "doi": "10.1667/rr2616.1",
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      "pmid": "21764987",
      "year": 2011,
      "title": "Die Wasserstofftherapie mildert strahlungsinduzierte Lungenschäden durch Reduktion von oxidativem Stress",
      "title_en": "Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress.",
      "title_de": null,
      "journal": "American journal of physiology. Lung cellular and molecular physiology",
      "authors": "Terasaki et al.",
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      "doi": "10.1152/ajplung.00008.2011",
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    {
      "pmid": "21656033",
      "year": 2011,
      "title": "Herstellung und Charakterisierung bioaktiver Verbundbeschichtungen auf einer Mg-Zn-Ca-Legierung durch MAO/Sol-Gel",
      "title_en": "Fabrication and characterization of bioactive composite coatings on Mg-Zn-Ca alloy by MAO/sol-gel.",
      "title_de": null,
      "journal": "Journal of materials science. Materials in medicine",
      "authors": "Gao et al.",
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      "doi": "10.1007/s10856-011-4349-9",
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      "year": 2011,
      "title": "Wasserstoffreiches Medium schützt menschliche Hautfibroblasten vor durch hohe Glukose oder Mannitol induzierten oxidativen Schäden",
      "title_en": "Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage.",
      "title_de": null,
      "journal": "Biochemical and biophysical research communications",
      "authors": "Yu et al.",
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      "doi": "10.1016/j.bbrc.2011.05.024",
      "doi_url": "https://doi.org/10.1016/j.bbrc.2011.05.024",
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      "url": "https://h2medizin.org/studien/studie-yu-2011-medium-schuetzt-menschliche-hautfibroblasten/",
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    {
      "pmid": "21455114",
      "year": 2011,
      "title": "Eine mögliche Präventionsstrategie für Strahlenpneumonitis: Kombination von Strahlentherapie mit Aerosol-Inhalation einer wasserstoffreichen Lösung",
      "title_en": "A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution.",
      "title_de": null,
      "journal": "Medical science monitor : international medical journal of experimental and clinical research",
      "authors": "Chuai et al.",
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      "doi": "10.12659/msm.881698",
      "doi_url": "https://doi.org/10.12659/msm.881698",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21455114/",
      "url": "https://h2medizin.org/studien/studie-chuai-2011-moegliche-praeventionsstrategie-strahlenpneumonitis-kombination/",
      "methods": [
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    {
      "pmid": "21335650",
      "year": 2011,
      "title": "Erzeugung klinisch nutzbarer Positronenstrahler-Strahlen während der Abbremsung von Kohlenstoffionen",
      "title_en": "Production of clinically useful positron emitter beams during carbon ion deceleration.",
      "title_de": null,
      "journal": "Physics in medicine and biology",
      "authors": "Lazzeroni et al.",
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      "doi": "10.1088/0031-9155/56/6/005",
      "doi_url": "https://doi.org/10.1088/0031-9155/56/6/005",
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      "url": "https://h2medizin.org/studien/studie-lazzeroni-2011-erzeugung-klinisch-nutzbarer-positronenstrahler/",
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    {
      "pmid": "21269826",
      "year": 2011,
      "title": "Chinazoline mit intramolekularem Wasserstoffbrücken-Gerüst (iMHBS) als duale PI3K/mTOR-Inhibitoren",
      "title_en": "Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.",
      "title_de": null,
      "journal": "Bioorganic & medicinal chemistry letters",
      "authors": "Liu et al.",
      "author_search": "liu liu",
      "doi": "10.1016/j.bmcl.2010.12.026",
      "doi_url": "https://doi.org/10.1016/j.bmcl.2010.12.026",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21269826/",
      "url": "https://h2medizin.org/studien/studie-liu-2011-chinazoline-intramolekularem-wasserstoffbruecken-geruest/",
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    {
      "pmid": "21215337",
      "year": 2011,
      "title": "Perfusions-Elektrodeposition von Calciumphosphat auf additiv gefertigten Titangerüsten für das Knochen-Engineering",
      "title_en": "Perfusion electrodeposition of calcium phosphate on additive manufactured titanium scaffolds for bone engineering.",
      "title_de": null,
      "journal": "Acta biomaterialia",
      "authors": "Chai et al.",
      "author_search": "chai chai",
      "doi": "10.1016/j.actbio.2010.12.032",
      "doi_url": "https://doi.org/10.1016/j.actbio.2010.12.032",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/21215337/",
      "url": "https://h2medizin.org/studien/studie-chai-2011-perfusions-elektrodeposition-calciumphosphat-additiv/",
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    {
      "pmid": "20851533",
      "year": 2011,
      "title": "Die Wasserstofftherapie könnte die mit strahlungsinduziertem oxidativem Stress verbundenen Risiken bei der Raumfahrt reduzieren",
      "title_en": "Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight.",
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      "title_en": "[Research advances on hydrogen therapy in nervous system diseases].",
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      "title": "Computergestützte Glykowissenschaft: Charakterisierung der räumlichen und zeitlichen Eigenschaften von Glykanen und Glykan-Protein-Komplexen.",
      "title_en": "Computational glycoscience: characterizing the spatial and temporal properties of glycans and glycan-protein complexes.",
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      "title": "Amyloidbildung in Tensiden und Alkoholen: Membranmimetika oder strukturelle Umschalter?",
      "title_en": "Amyloid formation in surfactants and alcohols: membrane mimetics or structural switchers?",
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      "title": "Wasserstoff als neuartige und wirksame Behandlung der akuten Kohlenmonoxidvergiftung.",
      "title_en": "Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning.",
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      "title": "Wirksamkeit von wasserstoffreichem Wasser auf den Antioxidans-Status von Personen mit potenziellem metabolischem Syndrom — eine offene Pilotstudie",
      "title_en": "Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome - an open label pilot study",
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    {
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      "title": "Die Hypothese eines wirksamen, sicheren und neuartigen Radioprotektors: wasserstoffreiche Lösung.",
      "title_en": "The hypothesis of an effective safe and novel radioprotective agent: hydrogen-rich solution.",
      "title_de": null,
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      "title": "Antitumorwirkungen von Wasser mit gelöstem Nanobläschen-Wasserstoff werden durch koexistierendes Platin-Kolloid und die kombinierte Hyperthermie mit apoptoseähnlichem Zelltod verstärkt.",
      "title_en": "Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death.",
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      "pmid": "20858206",
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      "title": "Spontaner Anpassungsmechanismus in einem RNA-bindenden Protein: Zusammenwirken von energetischer Stabilisierung und Verbesserung der Zielsuche.",
      "title_en": "Spontaneous adjustment mechanism in an RNA-binding protein: cooperation between energetic stabilization and target search enhancement.",
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    {
      "pmid": "20801581",
      "year": 2010,
      "title": "Die orale Verabreichung von Mannitol könnte eine wirksame Behandlung des Ischämie-Reperfusions-Schadens sein.",
      "title_en": "Oral administration of mannitol may be an effective treatment for ischemia-reperfusion injury.",
      "title_de": null,
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      "title": "Die Behandlung mit Wasserstoffgas verlängert die replikative Lebensspanne multipotenter Knochenmark-Stromazellen in vitro unter Erhaltung des Differenzierungs- und parakrinen Potenzials.",
      "title_en": "Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials.",
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      "title": "Ein neuartiges bioaktives Hämodialysesystem unter Verwendung von gelöstem Diwasserstoff (H₂), erzeugt durch Wasserelektrolyse: eine klinische Studie",
      "title_en": "A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial.",
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      "pmid": "20298796",
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      "title": "Mikrobielle Equol-Produktion mildert kolische Methanogenese und Sulfidogenese in vitro.",
      "title_en": "Microbial equol production attenuates colonic methanogenesis and sulphidogenesis in vitro.",
      "title_de": null,
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      "title": "Eine biologisch abbaubare polymerbasierte Beschichtung zur Steuerung der Leistung von orthopädischen Implantaten aus Magnesiumlegierung.",
      "title_en": "A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants.",
      "title_de": null,
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      "pmid": "19765780",
      "year": 2010,
      "title": "Versagen von im Dünndarm absorbierter D-Psicose, in Energie verstoffwechselt zu werden, und ihre geringe Fermentierbarkeit im Dickdarm beim Menschen",
      "title_en": "Failure of d-psicose absorbed in the small intestine to metabolize into energy and its low large intestinal fermentability in humans.",
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      "pmid": "19725814",
      "year": 2010,
      "title": "Verwendung der Laser-Speckle-Flowgraphie in der Forschung zum okulären Blutfluss.",
      "title_en": "Use of laser speckle flowgraphy in ocular blood flow research.",
      "title_de": null,
      "journal": "Acta ophthalmologica",
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      "year": 2010,
      "title": "Die Wasserstofftherapie könnte eine wirksame und spezifische neuartige Behandlung für das akute Strahlensyndrom sein.",
      "title_en": "Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome.",
      "title_de": null,
      "journal": "Medical hypotheses",
      "authors": "Liu et al.",
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    {
      "pmid": "19505462",
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      "title": "Stehen die Wirkungen von Alpha-Glucosidase-Hemmern auf kardiovaskuläre Ereignisse im Zusammenhang mit erhöhten Wasserstoffgasspiegeln im Magen-Darm-Trakt?",
      "title_en": "Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?",
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      "year": 2009,
      "title": "Wasserstoff vermittelt die Unterdrückung der durch Dextran-Natriumsulfat induzierten Kolonentzündung.",
      "title_en": "Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.",
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      "authors": "Kajiya et al.",
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      "pmid": "19377306",
      "year": 2009,
      "title": "Ein neuartiges Antikörperfragment, das auf HAb18G/CD147 abzielt, mit Zytotoxizität und verringerter Immunogenität.",
      "title_en": "A novel antibody fragment targeting HAb18G/CD147 with cytotoxicity and decreased immunogenicity.",
      "title_de": null,
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      "authors": "Zhu et al.",
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    {
      "pmid": "19237201",
      "year": 2009,
      "title": "Organozinn-Meclofenaminsäure-Komplexe: Synthese, Kristallstrukturen und antiproliferative Aktivität der ersten Komplexe der Meclofenaminsäure – neuartige Antituberkulose-Wirkstoffe.",
      "title_en": "Organotin meclofenamic complexes: Synthesis, crystal structures and antiproliferative activity of the first complexes of meclofenamic acid - novel anti-tuberculosis agents.",
      "title_de": null,
      "journal": "Journal of inorganic biochemistry",
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      "doi": "10.1016/j.jinorgbio.2009.01.014",
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      "pmid": "19202298",
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      "title": "Verstärkte Induktion mitochondrialer Schäden und Apoptose in menschlichen Leukämie-HL-60-Zellen durch elektrolysiert-reduziertes Wasser und Glutathion.",
      "title_en": "Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione.",
      "title_de": null,
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      "authors": "Tsai et al.",
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      "title": "Der Mechanismus der Abscheidung von Calciumphosphat-Beschichtungen aus Lösung auf der Magnesiumlegierung AZ31.",
      "title_en": "The mechanism of deposition of calcium phosphate coatings from solution onto magnesium alloy AZ31.",
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      "title": "Das Hydrogenosom als Wirkstoffziel.",
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      "title": "Eine Rolle von IOP1 in der Biogenese zytosolischer Eisen-Schwefel-Proteine bei Säugetieren.",
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      "title": "Wasserstoff als Energiequelle für den humanpathogenen Erreger Bilophila wadsworthia.",
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      "title": "Vorläufige tribologische Bewertung nanostrukturierter Diamantbeschichtungen gegen ultrahochmolekulares Polyethylen.",
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      "title": "Praktische Erfahrungen mit der Synthese von [¹¹C]CH₃I durch eine Gasphasen-Iodierungsreaktion unter Verwendung eines TRACERlabFXC-Synthesemoduls",
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      "title_en": "A mitosome purification protocol based on percoll density gradients and its use in validating the mitosomal nature of Entamoeba histolytica mitochondrial Hsp70.",
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      "title_en": "[Blood flow and morphofunctional status of gastroduodenal mucosa in different phases of peptic ulcer].",
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      "title": "Elektrolysiert-reduziertes Wasser schützt vor oxidativen Schäden an DNA, RNA und Protein",
      "title_en": "Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein.",
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      "title_en": "Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients.",
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      "title": "Nutzung von molekularem Wasserstoff als Energiesubstrat durch humanpathogene Bakterien",
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      "title": "Isolierung und Charakterisierung einer equolproduzierenden gemischten mikrobiellen Kultur aus einer menschlichen Stuhlprobe und ihre Aktivität unter gastrointestinalen Bedingungen",
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      "title": "Methoden zur Wasserstoffspeicherung",
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      "title": "Untersuchungen an menschlichem Brustkrebsgewebe mittels Raman-Mikrospektroskopie",
      "title_en": "[Studies on human breast cancer tissues with Raman microspectroscopy].",
      "title_de": null,
      "journal": "Guang pu xue yu guang pu fen xi = Guang pu",
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      "title": "Bioverfügbarkeit von Cellobiose mittels Toleranztest und Atemwasserstoffausscheidung beim Menschen",
      "title_en": "Bioavailability of cellobiose by tolerance test and breath hydrogen excretion in humans.",
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      "title": "Verringerter hämodialyseinduzierter oxidativer Stress bei Patienten mit terminaler Niereninsuffizienz durch elektrolytisch reduziertes Wasser.",
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      "title": "Fe-only-Hydrogenasen: Struktur, Funktion und Evolution",
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      "title": "Melatonin, mitochondriale Homöostase und mitochondrienbedingte Erkrankungen",
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      "title": "Kristallstruktur des humanen sexualhormonbindenden Globulins im Komplex mit 2-Methoxyestradiol offenbart die molekulare Grundlage für hochaffine Interaktionen mit C-2-Derivaten von Estradiol",
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      "year": 2002,
      "title": "Hydrogenasen in Grünalgen: Retten sie das Leben der Algen und lösen sie unsere Energieprobleme?",
      "title_en": "Hydrogenases in green algae: do they save the algae's life and solve our energy problems?",
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      "year": 2002,
      "title": "Konservierte Eigenschaften hydrogenosomaler und mitochondrialer ADP/ATP-Carrier: ein gemeinsamer Ursprung für beide Organellen.",
      "title_en": "Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles.",
      "title_de": null,
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      "title": "Tritium-Dosen aus chronischen atmosphärischen Freisetzungen: ein neuer Ansatz zur Einhaltung regulatorischer Vorgaben.",
      "title_en": "Tritium doses from chronic atmospheric releases: a new approach proposed for regulatory compliance.",
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      "year": 2001,
      "title": "Lactulose-induzierte Pneumatosis intestinalis und Pneumoperitoneum.",
      "title_en": "Lactulose-induced pneumatosis intestinalis and pneumoperitoneum.",
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      "year": 2001,
      "title": "Morphologische Variation der Hydrogenosomen induziert durch Fibronektin und andere Wirkstoffe bei Trichomonas vaginalis und Tritrichomonas foetus.",
      "title_en": "Hydrogenosome morphological variation induced by fibronectin and other drugs in Trichomonas vaginalis and Tritrichomonas foetus.",
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      "title": "Kristallstruktur der bovinen Duodenase, einer Serinprotease, mit dualer trypsin- und chymotrypsinähnlicher Spezifität.",
      "title_en": "Crystal structure of bovine duodenase, a serine protease, with dual trypsin and chymotrypsin-like specificities.",
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      "title": "Verbesserte Lactoseverdauung und -intoleranz bei afroamerikanischen heranwachsenden Mädchen unter milchreicher Ernährung.",
      "title_en": "Improved lactose digestion and intolerance among African-American adolescent girls fed a dairy-rich diet.",
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      "title": "Endoskopische Messung der pankreatischen Gewebeperfusion bei Patienten mit chronischer Pankreatitis und Kontrollpatienten.",
      "title_en": "Endoscopic measurement of pancreatic tissue perfusion in patients with chronic pancreatitis and control patients.",
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      "title": "Lactoseintoleranz bei Kindern. Eine Analyse von Wasserstoffgas in der Ausatemluft vereinfacht und verbessert die Diagnose.",
      "title_en": "[Lactose intolerance in children. An analysis of hydrogen gas in exhaled air simplifies and improves diagnosis].",
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      "title": "Folgen der unvollständigen Kohlenhydratabsorption beim Konsum von Fruchtsaft bei Säuglingen.",
      "title_en": "Consequences of incomplete carbohydrate absorption from fruit juice consumption in infants.",
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      "year": 1999,
      "title": "Der Transport von Sauerstoff- und Wasserstoffgas durch lebende C6-Zellsuspensionen ist schneller als der in toten Zellen.",
      "title_en": "Oxygen and hydrogen gas transport through living C6 cell suspensions is faster than that in dead cells.",
      "title_de": null,
      "journal": "Advances in experimental medicine and biology",
      "authors": "Tomita et al.",
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      "year": 1999,
      "title": "Eine präventive Wirkung eines selektiven Endothelin-A-Rezeptor-Antagonisten, S-0139, auf die erythropoetininduzierte Verminderung des renalen kortikalen Blutflusses.",
      "title_en": "A preventive effect of a selective endothelin-A receptor antagonist, S-0139, on the erythropoietin-induced reduction of the renal cortical blood flow.",
      "title_de": null,
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      "title": "Rolle des Calcitonin Gene-Related Peptide und capsaicinsensitiver Afferenzen bei der zentral durch Thyrotropin-Releasing-Hormon induzierten hepatischen Hyperämie.",
      "title_en": "Role of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic hyperemia.",
      "title_de": null,
      "journal": "European journal of pharmacology",
      "authors": "Tamori et al.",
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      "title": "CTAB-vermittelte Anreicherung aktiver Formen neuartiger dimerer Maxizyme.",
      "title_en": "CTAB-mediated enrichment for active forms of novel dimeric maxizymes.",
      "title_de": null,
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      "authors": "Nakayama et al.",
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      "title": "Anaerobe Transformation von Quercetin-3-glucosid durch Bakterien aus dem menschlichen Darmtrakt.",
      "title_en": "Anaerobic transformation of quercetin-3-glucoside by bacteria from the human intestinal tract.",
      "title_de": null,
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      "pmid": "9515746",
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      "title": "¹³C-Atemtest in der gastroenterologischen Praxis.",
      "title_en": "13C breath test in gastroenterological practice.",
      "title_de": null,
      "journal": "Scandinavian journal of gastroenterology. Supplement",
      "authors": "Swart et al.",
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      "doi": null,
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      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/9515746/",
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    {
      "pmid": "9867093",
      "year": 1998,
      "title": "Fructose-Sorbit-Malabsorption und Symptomprovokation beim Reizdarmsyndrom: Beziehung zu enteraler Hypersensitivität und Dysmotilität.",
      "title_en": "Fructose-sorbitol malabsorption and symptom provocation in irritable bowel syndrome: relationship to enteric hypersensitivity and dysmotility.",
      "title_de": null,
      "journal": "Scandinavian journal of gastroenterology",
      "authors": "Evans et al.",
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      "doi": "10.1080/00365529850172502",
      "doi_url": "https://doi.org/10.1080/00365529850172502",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/9867093/",
      "url": "https://h2medizin.org/studien/studie-evans-1998-fructose-sorbit-malabsorption-symptomprovokation/",
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      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "9771858",
      "year": 1998,
      "title": "Energieumsatz und Netto-Substratverwertung bei Männern, die übliche und hohe Mengen an Nicht-Stärke-Polysacchariden zu sich nehmen",
      "title_en": "Energy expenditure and net substrate utilization in men ingesting usual and high amounts of nonstarch polysaccharide.",
      "title_de": null,
      "journal": "The American journal of clinical nutrition",
      "authors": "Poppitt et al.",
      "author_search": "poppitt poppitt",
      "doi": "10.1093/ajcn/68.4.820",
      "doi_url": "https://doi.org/10.1093/ajcn/68.4.820",
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      "url": "https://h2medizin.org/studien/studie-poppitt-1998-energieumsatz-netto-substratverwertung-maennern/",
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      "evidence_level": 3,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "9492232",
      "year": 1998,
      "title": "Ein einstündiger aktiver Bewältigungsstressor verkürzt die Dünndarmpassagezeit bei gesunden jungen Erwachsenen",
      "title_en": "A one-hour active coping stressor reduces small bowel transit time in healthy young adults.",
      "title_de": null,
      "journal": "Psychosomatic medicine",
      "authors": "Ditto et al.",
      "author_search": "ditto ditto",
      "doi": "10.1097/00006842-199801000-00002",
      "doi_url": "https://doi.org/10.1097/00006842-199801000-00002",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/9492232/",
      "url": "https://h2medizin.org/studien/studie-ditto-1998-einstuendiger-aktiver-bewaeltigungsstressor-verkuerzt/",
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      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "8870180",
      "year": 1996,
      "title": "Magnetisierungstransfer-Magnetresonanztomographie: eine klinische Übersichtsarbeit",
      "title_en": "Magnetization transfer magnetic resonance imaging: a clinical review.",
      "title_de": null,
      "journal": "Topics in magnetic resonance imaging : TMRI",
      "authors": "Mehta et al.",
      "author_search": "mehta mehta",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8870180/",
      "url": "https://h2medizin.org/studien/studie-mehta-1996-magnetisierungstransfer-magnetresonanztomographie-klinische-uebersichtsarbeit/",
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        "skin-aging"
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      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "8613657",
      "year": 1996,
      "title": "Wie viel Lactose ist wenig Lactose?",
      "title_en": "How much lactose is low lactose?",
      "title_de": null,
      "journal": "Journal of the American Dietetic Association",
      "authors": "Hertzler et al.",
      "author_search": "hertzler hertzler",
      "doi": "10.1016/s0002-8223(96)00074-0",
      "doi_url": "https://doi.org/10.1016/s0002-8223(96)00074-0",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8613657/",
      "url": "https://h2medizin.org/studien/studie-hertzler-1996-wie-viel-lactose-ist/",
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      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "9127504",
      "year": 1996,
      "title": "Radiotoxizität von tritiiertem Wasser und tritiiertem Wasserstoff",
      "title_en": "Radiotoxicity of tritiated water and tritiated hydrogen.",
      "title_de": null,
      "journal": "Arhiv za higijenu rada i toksikologiju",
      "authors": "Franić",
      "author_search": "franić franić",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/9127504/",
      "url": "https://h2medizin.org/studien/studie-franic-1996-radiotoxizitaet-tritiiertem-tritiiertem/",
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
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    {
      "pmid": "7796506",
      "year": 1995,
      "title": "Beurteilung des intrakardialen Links-Rechts-Shunts mittels geschwindigkeitskodierter Phasenkontrast-Magnetresonanztomographie",
      "title_en": "Assessment of left-to-right intracardiac shunting by velocity-encoded, phase-difference magnetic resonance imaging. A comparison with oximetric and indicator dilution techniques.",
      "title_de": null,
      "journal": "Circulation",
      "authors": "Hundley et al.",
      "author_search": "hundley hundley",
      "doi": "10.1161/01.cir.91.12.2955",
      "doi_url": "https://doi.org/10.1161/01.cir.91.12.2955",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7796506/",
      "url": "https://h2medizin.org/studien/studie-hundley-1995-beurteilung-des-intrakardialen-links/",
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      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "7548544",
      "year": 1995,
      "title": "Energetik der Oxidation von molekularem Wasserstoff im oralen Pathogen Campylobacter rectus",
      "title_en": "Energetics of molecular hydrogen oxidation in the oral pathogen Campylobacter rectus.",
      "title_de": null,
      "journal": "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",
      "authors": "Gillespie et al.",
      "author_search": "gillespie gillespie",
      "doi": "10.1093/clinids/20.supplement_2.s172",
      "doi_url": "https://doi.org/10.1093/clinids/20.supplement_2.s172",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7548544/",
      "url": "https://h2medizin.org/studien/studie-gillespie-1995-energetik-oxidation-oralen-pathogen/",
      "methods": [
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      "human": false,
      "therapeutic": false,
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    {
      "pmid": "7919894",
      "year": 1994,
      "title": "Atemtests: eine Klärung des Themas",
      "title_en": "[Breath tests--a clarification of the topic].",
      "title_de": null,
      "journal": "Bildgebung = Imaging",
      "authors": "Beglinger",
      "author_search": "beglinger beglinger",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7919894/",
      "url": "https://h2medizin.org/studien/studie-beglinger-1994-atemtests-klaerung-des-themas/",
      "methods": [
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      "human": false,
      "therapeutic": false,
      "h2category": "review"
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    {
      "pmid": "7723185",
      "year": 1994,
      "title": "Experimentelle und klinische Studien zu ischämischen Läsionen des Dickdarms",
      "title_en": "[Experimental and clinical studies on ischemic lesions of the large intestine].",
      "title_de": null,
      "journal": "Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics",
      "authors": "Mizushima et al.",
      "author_search": "mizushima mizushima",
      "doi": "10.3143/geriatrics.31.835",
      "doi_url": "https://doi.org/10.3143/geriatrics.31.835",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7723185/",
      "url": "https://h2medizin.org/studien/studie-mizushima-1994-experimentelle-klinische-ischaemischen-laesionen/",
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      "h2category": "tracer-clearance"
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    {
      "pmid": "7932756",
      "year": 1994,
      "title": "Arzneistoff–Protein-Interaktionen: Verfeinerte Strukturen dreier Sulfonamid-Arzneistoffkomplexe des humanen Carboanhydrase-I-Enzyms",
      "title_en": "Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme.",
      "title_de": null,
      "journal": "Journal of molecular biology",
      "authors": "Chakravarty et al.",
      "author_search": "chakravarty chakravarty",
      "doi": "10.1006/jmbi.1994.1655",
      "doi_url": "https://doi.org/10.1006/jmbi.1994.1655",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7932756/",
      "url": "https://h2medizin.org/studien/studie-chakravarty-1994-arzneistoff-protein-interaktionen-verfeinerte/",
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      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "8062196",
      "year": 1994,
      "title": "Chemotherapieinduzierte Lactoseintoleranz bei Erwachsenen",
      "title_en": "Chemotherapy-induced lactose intolerance in adults.",
      "title_de": null,
      "journal": "Cancer",
      "authors": "Parnes et al.",
      "author_search": "parnes parnes",
      "doi": "10.1002/1097-0142(19940901)74:5<1629::aid-cncr2820740523>3.0.co;2-l",
      "doi_url": "https://doi.org/10.1002/1097-0142(19940901)74:5<1629::aid-cncr2820740523>3.0.co;2-l",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8062196/",
      "url": "https://h2medizin.org/studien/studie-parnes-1994-chemotherapieinduzierte-lactoseintoleranz-erwachsenen/",
      "methods": [],
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      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "8003641",
      "year": 1994,
      "title": "Eine mögliche Rolle von Gallensäure bei der Kontrolle der Methanogenese und der Akkumulation von Wasserstoffgas im menschlichen Kolon",
      "title_en": "A possible role for bile acid in the control of methanogenesis and the accumulation of hydrogen gas in the human colon.",
      "title_de": null,
      "journal": "Journal of gastroenterology and hepatology",
      "authors": "Florin et al.",
      "author_search": "florin florin",
      "doi": "10.1111/j.1440-1746.1994.tb01228.x",
      "doi_url": "https://doi.org/10.1111/j.1440-1746.1994.tb01228.x",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8003641/",
      "url": "https://h2medizin.org/studien/studie-florin-1994-moegliche-rolle-gallensaeure-kontrolle/",
      "methods": [
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      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "8041275",
      "year": 1994,
      "title": "Regeneration von funktionellem Hämoglobin aus teilweise oxidiertem Hämoglobin in Gegenwart von molekularem Wasserstoff und einem Mehrkomponenten-Redoxkatalysator",
      "title_en": "Regeneration of functional hemoglobin from partially oxidized hemoglobin in the presence of molecular hydrogen and a multicomponent redox catalyst.",
      "title_de": null,
      "journal": "Methods in enzymology",
      "authors": "McGown et al.",
      "author_search": "mcgown mc gown",
      "doi": "10.1016/0076-6879(94)31037-8",
      "doi_url": "https://doi.org/10.1016/0076-6879(94)31037-8",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8041275/",
      "url": "https://h2medizin.org/studien/studie-mcgown-1994-regeneration-funktionellem-haemoglobin-aus/",
      "methods": [
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      "human": false,
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    },
    {
      "pmid": "7949764",
      "year": 1994,
      "title": "Beurteilung des trachealen Mukosa-Blutflusses während einer erweiterten Radikaloperation bei Ösophaguskarzinom",
      "title_en": "Evaluation of tracheal mucosal blood flow during an extended radical operation for esophageal carcinoma: clinical and experimental studies.",
      "title_de": null,
      "journal": "Surgery today",
      "authors": "Nakahara et al.",
      "author_search": "nakahara nakahara",
      "doi": "10.1007/bf01833720",
      "doi_url": "https://doi.org/10.1007/bf01833720",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7949764/",
      "url": "https://h2medizin.org/studien/studie-nakahara-1994-beurteilung-des-trachealen-mukosa/",
      "methods": [],
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      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "8112709",
      "year": 1993,
      "title": "Wirkung endogener Opioide auf die Magenfunktionen beim Menschen",
      "title_en": "[Effect of endogenous opioids on gastric functions in man].",
      "title_de": null,
      "journal": "[Hokkaido igaku zasshi] The Hokkaido journal of medical science",
      "authors": "Suzuki",
      "author_search": "suzuki suzuki",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8112709/",
      "url": "https://h2medizin.org/studien/studie-suzuki-1993-endogener-opioide-magenfunktionen-beim/",
      "methods": [],
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      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "8249850",
      "year": 1993,
      "title": "Wasserstoffinhalation zum Nachweis intrakardialer Links-Rechts-Shunts bei Erwachsenen",
      "title_en": "Hydrogen inhalation for detecting intracardiac left-to-right shunting in adults.",
      "title_de": null,
      "journal": "The American journal of cardiology",
      "authors": "Glamann et al.",
      "author_search": "glamann glamann",
      "doi": "10.1016/0002-9149(93)90890-o",
      "doi_url": "https://doi.org/10.1016/0002-9149(93)90890-o",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8249850/",
      "url": "https://h2medizin.org/studien/studie-glamann-1993-wasserstoffinhalation-zum-nachweis-intrakardialer/",
      "methods": [],
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        "respiratory"
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      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "8357854",
      "year": 1993,
      "title": "Eine vereinfachte Methode zur Messung des Deuterium/Wasserstoff-Isotopenverhältnisses an Wasserproben biologischen Ursprungs",
      "title_en": "A simplified method for deuterium/hydrogen isotope ratio measurements on water samples of biological origin.",
      "title_de": null,
      "journal": "Biological mass spectrometry",
      "authors": "Scrimgeour et al.",
      "author_search": "scrimgeour scrimgeour",
      "doi": "10.1002/bms.1200220704",
      "doi_url": "https://doi.org/10.1002/bms.1200220704",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/8357854/",
      "url": "https://h2medizin.org/studien/studie-scrimgeour-1993-vereinfachte-methode-zur-messung/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "1489103",
      "year": 1992,
      "title": "Regeneration von funktionellem Hämoglobin aus Eisen(III)-Hämoglobin durch Reduktion mit Wasserstoff und einem heterogenen Katalysator",
      "title_en": "Regeneration of functional hemoglobin from iron(III) hemoglobin by reduction with hydrogen and a heterogeneous catalyst.",
      "title_de": null,
      "journal": "Analytical biochemistry",
      "authors": "McGown et al.",
      "author_search": "mcgown mc gown",
      "doi": "10.1016/0003-2697(92)90505-2",
      "doi_url": "https://doi.org/10.1016/0003-2697(92)90505-2",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/1489103/",
      "url": "https://h2medizin.org/studien/studie-mcgown-1992-regeneration-funktionellem-haemoglobin-aus/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "1318087",
      "year": 1992,
      "title": "Kristallographische Veränderungen in Calciumphosphaten während des Plasmaspritzens",
      "title_en": "Crystallographic changes in calcium phosphates during plasma-spraying.",
      "title_de": null,
      "journal": "Biomaterials",
      "authors": "Ellies et al.",
      "author_search": "ellies ellies",
      "doi": "10.1016/0142-9612(92)90055-s",
      "doi_url": "https://doi.org/10.1016/0142-9612(92)90055-s",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/1318087/",
      "url": "https://h2medizin.org/studien/studie-ellies-1992-kristallographische-veraenderungen-calciumphosphaten-waehrend/",
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      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "1313759",
      "year": 1992,
      "title": "Ein neues Zinkprodukt zur Reduktion von Wasser in physiologischen Flüssigkeiten zu Wasserstoffgas für ²H/¹H-Isotopenverhältnis-Messungen",
      "title_en": "A new zinc product for the reduction of water in physiological fluids to hydrogen gas for 2H/1H isotope ratio measurements.",
      "title_de": null,
      "journal": "European journal of clinical nutrition",
      "authors": "Wong et al.",
      "author_search": "wong wong",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/1313759/",
      "url": "https://h2medizin.org/studien/studie-wong-1992-neues-zinkprodukt-zur-reduktion/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "1792946",
      "year": 1991,
      "title": "Kein Hinweis auf einen Effekt eines Lactasemangels auf die Knochenmasse bei prä- oder postmenopausalen Frauen",
      "title_en": "No evidence for an effect of lactase deficiency on bone mass in pre- or postmenopausal women.",
      "title_de": null,
      "journal": "Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research",
      "authors": "Slemenda et al.",
      "author_search": "slemenda slemenda",
      "doi": "10.1002/jbmr.5650061214",
      "doi_url": "https://doi.org/10.1002/jbmr.5650061214",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/1792946/",
      "url": "https://h2medizin.org/studien/studie-slemenda-1991-kein-hinweis-einen-effekt/",
      "methods": [],
      "indications": [
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        "womens-health"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "1651893",
      "year": 1991,
      "title": "Schützende Wirkung von Rebamipid (OPC-12759) auf die Magenschleimhaut bei Ratten und Menschen",
      "title_en": "[Protective effect of rebamipide (OPC-12759) on the gastric mucosa in rats and humans].",
      "title_de": null,
      "journal": "Nihon yakurigaku zasshi. Folia pharmacologica Japonica",
      "authors": "Kawano et al.",
      "author_search": "kawano kawano",
      "doi": "10.1254/fpj.97.6_371",
      "doi_url": "https://doi.org/10.1254/fpj.97.6_371",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/1651893/",
      "url": "https://h2medizin.org/studien/studie-kawano-1991-schuetzende-rebamipid-opc-12759/",
      "methods": [
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        "drinking-hrw"
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "2379871",
      "year": 1990,
      "title": "Alternative Wege zur Wasserstoffbeseitigung während der Fermentation im menschlichen Kolon.",
      "title_en": "Alternative pathways for hydrogen disposal during fermentation in the human colon.",
      "title_de": null,
      "journal": "Gut",
      "authors": "Gibson et al.",
      "author_search": "gibson gibson",
      "doi": "10.1136/gut.31.6.679",
      "doi_url": "https://doi.org/10.1136/gut.31.6.679",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2379871/",
      "url": "https://h2medizin.org/studien/studie-gibson-1990-alternative-wege-zur-wasserstoffbeseitigung/",
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        "other"
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      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "2191785",
      "year": 1990,
      "title": "Beurteilung der Sensitivität der Wasserstoffinhalation beim Nachweis von Links-Rechts-Shunts",
      "title_en": "Assessment of the sensitivity of hydrogen inhalation in the detection of left-to-right shunting.",
      "title_de": null,
      "journal": "Catheterization and cardiovascular diagnosis",
      "authors": "Flores et al.",
      "author_search": "flores flores",
      "doi": "10.1002/ccd.1810200206",
      "doi_url": "https://doi.org/10.1002/ccd.1810200206",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2191785/",
      "url": "https://h2medizin.org/studien/studie-flores-1990-beurteilung-sensitivitaet-wasserstoffinhalation-beim/",
      "methods": [],
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        "respiratory"
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      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
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    {
      "pmid": "2365796",
      "year": 1990,
      "title": "Messung des hepatischen Blutflusses mittels Wasserstoffgas-Clearance-Methode: Experimentelle und klinische Beobachtungen",
      "title_en": "[Measurement of hepatic blood flow by the hydrogen gas clearance method. Experimental and clinical observations].",
      "title_de": null,
      "journal": "Nihon Ika Daigaku zasshi",
      "authors": "Makino",
      "author_search": "makino makino",
      "doi": "10.1272/jnms1923.57.137",
      "doi_url": "https://doi.org/10.1272/jnms1923.57.137",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2365796/",
      "url": "https://h2medizin.org/studien/studie-makino-1990-messung-des-hepatischen-blutflusses/",
      "methods": [],
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        "cancer"
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      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "2314375",
      "year": 1990,
      "title": "Korrelation zwischen gastraler Mikrozirkulation und Mukosaschädigung nach chirurgischer Therapie von Ösophagusvarizen.",
      "title_en": "[Correlation between gastric microcirculation and mucosal injury after surgical therapy of esophageal varices].",
      "title_de": null,
      "journal": "Nihon Geka Gakkai zasshi",
      "authors": "Mitarai et al.",
      "author_search": "mitarai mitarai",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2314375/",
      "url": "https://h2medizin.org/studien/studie-mitarai-1990-korrelation-zwischen-gastraler-mikrozirkulation/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "2666015",
      "year": 1989,
      "title": "Auswirkungen der Sphäroplastenbildung von Escherichia coli auf H₂- und Adenosintriphosphat-basierte Ampicillin-Empfindlichkeitstests.",
      "title_en": "Effects of Escherichia coli spheroplast formation on assays of H2 and adenosine triphosphate based ampicillin susceptibility tests.",
      "title_de": null,
      "journal": "Diagnostic microbiology and infectious disease",
      "authors": "Hörnsten et al.",
      "author_search": "hörnsten hörnsten",
      "doi": "10.1016/0732-8893(89)90009-6",
      "doi_url": "https://doi.org/10.1016/0732-8893(89)90009-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2666015/",
      "url": "https://h2medizin.org/studien/studie-hoernsten-1989-auswirkungen-sphaeroplastenbildung-escherichia-coli/",
      "methods": [
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "2496538",
      "year": 1989,
      "title": "GasPak Plus versus Anaerocult A – zwei Kohlendioxid/Wasserstoff-Systeme zur Kultivierung von Anaerobiern.",
      "title_en": "GasPak Plus versus Anaerocult A--two carbon dioxide/hydrogen systems for cultivation of anaerobes.",
      "title_de": null,
      "journal": "Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology",
      "authors": "Heizmann et al.",
      "author_search": "heizmann heizmann",
      "doi": "10.1016/s0176-6724(89)80022-7",
      "doi_url": "https://doi.org/10.1016/s0176-6724(89)80022-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2496538/",
      "url": "https://h2medizin.org/studien/studie-heizmann-1989-gaspak-plus-versus-anaerocult/",
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        "cardiovascular"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "3140651",
      "year": 1988,
      "title": "Die Akzeptanz von Milch und Milchprodukten in Bevölkerungsgruppen mit hoher Prävalenz von Lactoseintoleranz.",
      "title_en": "The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance.",
      "title_de": null,
      "journal": "The American journal of clinical nutrition",
      "authors": "Scrimshaw et al.",
      "author_search": "scrimshaw scrimshaw",
      "doi": "10.1093/ajcn/48.4.1142",
      "doi_url": "https://doi.org/10.1093/ajcn/48.4.1142",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3140651/",
      "url": "https://h2medizin.org/studien/studie-scrimshaw-1988-akzeptanz-milch-milchprodukten-bevoelkerungsgruppen/",
      "methods": [
        "inhalation",
        "drinking-hrw"
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        "other"
      ],
      "evidence_level": 4,
      "human": false,
      "therapeutic": false,
      "h2category": "review"
    },
    {
      "pmid": "2831734",
      "year": 1988,
      "title": "Rolle des Blutflusses bei der Magensäuresekretion.",
      "title_en": "Role of blood flow in gastric acid secretion.",
      "title_de": null,
      "journal": "The American journal of physiology",
      "authors": "Holm et al.",
      "author_search": "holm holm",
      "doi": "10.1152/ajpgi.1988.254.3.g281",
      "doi_url": "https://doi.org/10.1152/ajpgi.1988.254.3.g281",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2831734/",
      "url": "https://h2medizin.org/studien/studie-holm-1988-rolle-des-blutflusses-magensaeuresekretion/",
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      "human": false,
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    },
    {
      "pmid": "2849711",
      "year": 1988,
      "title": "Ballaststoffe und Gesundheit: die Rolle der Wasserstoffproduktion",
      "title_en": "Dietary fibre and health: the role of hydrogen production.",
      "title_de": null,
      "journal": "Medical hypotheses",
      "authors": "Neale",
      "author_search": "neale neale",
      "doi": "10.1016/0306-9877(88)90091-6",
      "doi_url": "https://doi.org/10.1016/0306-9877(88)90091-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2849711/",
      "url": "https://h2medizin.org/studien/studie-neale-1988-ballaststoffe-gesundheit-rolle-wasserstoffproduktion/",
      "methods": [],
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        "oxidative-stress"
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      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "3132563",
      "year": 1988,
      "title": "Wirkung einer endokrinen Behandlung auf den prostatischen Blutfluss bei Patienten mit prostatischem Adenokarzinom",
      "title_en": "Effect of endocrine treatment on prostatic blood flow in patients with prostatic adenocarcinoma.",
      "title_de": null,
      "journal": "The Journal of urology",
      "authors": "Toma et al.",
      "author_search": "toma toma",
      "doi": "10.1016/s0022-5347(17)41495-9",
      "doi_url": "https://doi.org/10.1016/s0022-5347(17)41495-9",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3132563/",
      "url": "https://h2medizin.org/studien/studie-toma-1988-endokrinen-den-prostatischen-blutfluss/",
      "methods": [],
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      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "3348155",
      "year": 1988,
      "title": "Nicht alle Joghurts sind gleich",
      "title_en": "All yogurts are not created equal.",
      "title_de": null,
      "journal": "The American journal of clinical nutrition",
      "authors": "Wytock et al.",
      "author_search": "wytock wytock",
      "doi": "10.1093/ajcn/47.3.454",
      "doi_url": "https://doi.org/10.1093/ajcn/47.3.454",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3348155/",
      "url": "https://h2medizin.org/studien/studie-wytock-1988-nicht-alle-joghurts-sind/",
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      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "2963569",
      "year": 1988,
      "title": "Endoskopische Messung des Magenmukosa-Blutflusses mittels Laser-Doppler-Velocimetrie: Wirkung der chronischen Ösophagusvarizen-Sklerosierung",
      "title_en": "Endoscopic measurement of gastric mucosal blood flow by laser Doppler velocimetry: effect of chronic esophageal variceal sclerosis.",
      "title_de": null,
      "journal": "The American surgeon",
      "authors": "Chung et al.",
      "author_search": "chung chung",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2963569/",
      "url": "https://h2medizin.org/studien/studie-chung-1988-endoskopische-messung-des-magenmukosa/",
      "methods": [],
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      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "3653647",
      "year": 1987,
      "title": "Gastroduodenale Mukosa-Hämodynamik mittels endoskopischer Reflexionsspektrophotometrie",
      "title_en": "Gastroduodenal mucosal hemodynamics by endoscopic reflectance spectrophotometry.",
      "title_de": null,
      "journal": "Gastrointestinal endoscopy",
      "authors": "Leung et al.",
      "author_search": "leung leung",
      "doi": "10.1016/s0016-5107(87)71599-5",
      "doi_url": "https://doi.org/10.1016/s0016-5107(87)71599-5",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3653647/",
      "url": "https://h2medizin.org/studien/studie-leung-1987-gastroduodenale-mukosa-haemodynamik-mittels/",
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      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "3303890",
      "year": 1987,
      "title": "Nachweis intrakardialer Links-Rechts-Shunts bei Erwachsenen: eine prospektive Analyse der Variabilität der Standard-Indocyaningrün-Technik",
      "title_en": "Detection of intracardiac left-to-right shunting in adults: a prospective analysis of the variability of the standard indocyanine green technique in patients without shunting.",
      "title_de": null,
      "journal": "The American journal of cardiology",
      "authors": "Niggemann et al.",
      "author_search": "niggemann niggemann",
      "doi": "10.1016/0002-9149(87)90242-6",
      "doi_url": "https://doi.org/10.1016/0002-9149(87)90242-6",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3303890/",
      "url": "https://h2medizin.org/studien/studie-niggemann-1987-nachweis-intrakardialer-links-rechts/",
      "methods": [],
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        "respiratory"
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      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "3578092",
      "year": 1987,
      "title": "Deuterium- und Sauerstoff-18-Messungen an Mikroliterproben von Urin, Plasma, Speichel und Muttermilch.",
      "title_en": "Deuterium and oxygen-18 measurements on microliter samples of urine, plasma, saliva, and human milk.",
      "title_de": null,
      "journal": "The American journal of clinical nutrition",
      "authors": "Wong et al.",
      "author_search": "wong wong",
      "doi": "10.1093/ajcn/45.5.905",
      "doi_url": "https://doi.org/10.1093/ajcn/45.5.905",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3578092/",
      "url": "https://h2medizin.org/studien/studie-wong-1987-deuterium-sauerstoff-messungen-mikroliterproben/",
      "methods": [
        "inhalation"
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      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "3095080",
      "year": 1986,
      "title": "Vergleich oraler Lavage-Methoden zur präoperativen Darmreinigung",
      "title_en": "Comparison of oral lavage methods for preoperative colonic cleansing.",
      "title_de": null,
      "journal": "Diseases of the colon and rectum",
      "authors": "Beck et al.",
      "author_search": "beck beck",
      "doi": "10.1007/bf02555311",
      "doi_url": "https://doi.org/10.1007/bf02555311",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3095080/",
      "url": "https://h2medizin.org/studien/studie-beck-1986-vergleich-oraler-lavage-methoden/",
      "methods": [],
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      "human": true,
      "therapeutic": false,
      "h2category": "byproduct"
    },
    {
      "pmid": "3749634",
      "year": 1986,
      "title": "Messung des Haut-Blutflusses mittels inhalierter Wasserstoffgas-Clearance-Methode",
      "title_en": "[Measurement of skin blood flow using inhaled hydrogen gas clearance method].",
      "title_de": null,
      "journal": "Kokyu to junkan. Respiration & circulation",
      "authors": "Nohara et al.",
      "author_search": "nohara nohara",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3749634/",
      "url": "https://h2medizin.org/studien/studie-nohara-1986-messung-des-haut-blutflusses/",
      "methods": [],
      "indications": [
        "skin-aging"
      ],
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      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "3943456",
      "year": 1986,
      "title": "Hämodynamik der Magenmukosa und Magenulzeration bei Ratten und bei Patienten mit Magenulkus.",
      "title_en": "Hemodynamics of the gastric mucosa and gastric ulceration in rats and in patients with gastric ulcer.",
      "title_de": null,
      "journal": "Digestive diseases and sciences",
      "authors": "Sato et al.",
      "author_search": "sato sato",
      "doi": "10.1007/bf01309321",
      "doi_url": "https://doi.org/10.1007/bf01309321",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3943456/",
      "url": "https://h2medizin.org/studien/studie-sato-1986-haemodynamik-magenmukosa-magenulzeration-ratten/",
      "methods": [
        "inhalation"
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        "other"
      ],
      "evidence_level": 1,
      "human": false,
      "therapeutic": false,
      "h2category": "preclinical"
    },
    {
      "pmid": "3485763",
      "year": 1986,
      "title": "Ätiopathogenese der hämorrhagischen Gastritis nach Ösophagustransektion mit erweiterter Devaskularisation bei Varizenpatienten",
      "title_en": "[Etiopathogenesis of hemorrhagic gastritis after esophageal transection extended devascularization in variceal patients].",
      "title_de": null,
      "journal": "Nihon Geka Gakkai zasshi",
      "authors": "Satani",
      "author_search": "satani satani",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3485763/",
      "url": "https://h2medizin.org/studien/studie-satani-1986-aetiopathogenese-haemorrhagischen-gastritis-oesophagustransektion/",
      "methods": [],
      "indications": [
        "cardiovascular"
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      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "2990189",
      "year": 1985,
      "title": "Auswirkungen von Ballaststoffen auf die Passagerate und den Atemwasserstoff",
      "title_en": "Dietary fiber effects on passage rate and breath hydrogen.",
      "title_de": null,
      "journal": "The American journal of clinical nutrition",
      "authors": "Hanson et al.",
      "author_search": "hanson hanson",
      "doi": "10.1093/ajcn/42.1.44",
      "doi_url": "https://doi.org/10.1093/ajcn/42.1.44",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2990189/",
      "url": "https://h2medizin.org/studien/studie-hanson-1985-auswirkungen-ballaststoffen-passagerate-den/",
      "methods": [],
      "indications": [
        "other"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "3989351",
      "year": 1985,
      "title": "Intestinaler Stoffwechsel eines zufallsverknüpften Polyglucose-Füllstoffs beim Menschen: In-vitro- und In-vivo-Studien zur Wasserstoffentwicklung",
      "title_en": "Intestinal metabolism of a random-bonded polyglucose bulking agent in humans: in vitro and in vivo studies of hydrogen evolution.",
      "title_de": null,
      "journal": "The Journal of laboratory and clinical medicine",
      "authors": "Solomons et al.",
      "author_search": "solomons solomons",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/3989351/",
      "url": "https://h2medizin.org/studien/studie-solomons-1985-intestinaler-stoffwechsel-zufallsverknuepften-polyglucose/",
      "methods": [],
      "indications": [
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      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "2578223",
      "year": 1985,
      "title": "Entwicklung der Kohlenhydratabsorption beim Fetus und Neugeborenen",
      "title_en": "Development of carbohydrate absorption in the fetus and neonate.",
      "title_de": null,
      "journal": "Pediatrics",
      "authors": "Mobassaleh et al.",
      "author_search": "mobassaleh mobassaleh",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/2578223/",
      "url": "https://h2medizin.org/studien/studie-mobassaleh-1985-entwicklung-kohlenhydratabsorption-beim-fetus/",
      "methods": [],
      "indications": [
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        "pregnancy"
      ],
      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "6530800",
      "year": 1984,
      "title": "Endoskopische Messung des Magenmukosa-Blutflusses mittels durch Elektrolyse erzeugtem Wasserstoffgas – Vergleich mit der H₂-Inhalationsmethode",
      "title_en": "[Endoscopic measurement of gastric mucosal blood flow by hydrogen gas generated by electrolysis--comparison with H2-inhalation method].",
      "title_de": null,
      "journal": "Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology",
      "authors": "Nishiwaki et al.",
      "author_search": "nishiwaki nishiwaki",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6530800/",
      "url": "https://h2medizin.org/studien/studie-nishiwaki-1984-endoskopische-messung-des-magenmukosa/",
      "methods": [],
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        "other"
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      "evidence_level": 2,
      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "6745722",
      "year": 1984,
      "title": "Steht erhöhter Atemwasserstoff im Zusammenhang mit der Pathogenese der Pneumatosis coli?",
      "title_en": "Is raised breath hydrogen related to the pathogenesis of pneumatosis coli?",
      "title_de": null,
      "journal": "Gut",
      "authors": "Read et al.",
      "author_search": "read read",
      "doi": "10.1136/gut.25.8.839",
      "doi_url": "https://doi.org/10.1136/gut.25.8.839",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6745722/",
      "url": "https://h2medizin.org/studien/studie-read-1984-steht-erhoehter-atemwasserstoff-zusammenhang/",
      "methods": [],
      "indications": [
        "sports-exercise"
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      "human": true,
      "therapeutic": false,
      "h2category": "breath-test"
    },
    {
      "pmid": "6745599",
      "year": 1984,
      "title": "Endoskopische Bestimmung des Magenmukosa-Blutflusses mittels der gekreuzten Thermoelement-Methode",
      "title_en": "Endoscopical determination of gastric mucosal blood flow by the crossed thermocouple method.",
      "title_de": null,
      "journal": "Gastroenterologia Japonica",
      "authors": "Hiramatsu et al.",
      "author_search": "hiramatsu hiramatsu",
      "doi": "10.1007/bf02779172",
      "doi_url": "https://doi.org/10.1007/bf02779172",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6745599/",
      "url": "https://h2medizin.org/studien/studie-hiramatsu-1984-endoskopische-bestimmung-des-magenmukosa/",
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    },
    {
      "pmid": "6717636",
      "year": 1984,
      "title": "Die Bestimmung von Wasserstoffgas in der Ausatemluft zur Diagnose von Kohlenhydratresorptionsstörungen",
      "title_en": "[The determination of hydrogen gas in the expired air for the diagnosis of carbohydrate resorption disorders].",
      "title_de": null,
      "journal": "Nederlands tijdschrift voor geneeskunde",
      "authors": "Dolmans et al.",
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      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6717636/",
      "url": "https://h2medizin.org/studien/studie-dolmans-1984-bestimmung-wasserstoffgas-ausatemluft-zur/",
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      "pmid": "6749107",
      "year": 1984,
      "title": "Experimentelle und klinische Studien zur ösophago-gastralen Hämodynamik vor und nach Devaskularisation bei Ösophagusvarizen",
      "title_en": "[Experimental and clinical studies on esophago-gastric hemodynamics before and after devascularization for esophageal varices].",
      "title_de": null,
      "journal": "Nihon Geka Gakkai zasshi",
      "authors": "Toyama",
      "author_search": "toyama toyama",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6749107/",
      "url": "https://h2medizin.org/studien/studie-toyama-1984-experimentelle-klinische-zur-oesophago/",
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    {
      "pmid": "6715939",
      "year": 1984,
      "title": "Der zervikale Blutfluss mittels Wasserstoffgas-Clearance-Methode",
      "title_en": "[The cervical blood flow using hydrogen gas clearance method].",
      "title_de": null,
      "journal": "Nihon Sanka Fujinka Gakkai zasshi",
      "authors": "Sakiyama",
      "author_search": "sakiyama sakiyama",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6715939/",
      "url": "https://h2medizin.org/studien/studie-sakiyama-1984-zervikale-blutfluss-mittels-wasserstoffgas/",
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    {
      "pmid": "6624949",
      "year": 1983,
      "title": "Transiente Lösungen von Gleichungen für den Gegenstrom-Kapillaraustausch.",
      "title_en": "Transient solutions of equations for countercurrent capillary exchange.",
      "title_de": null,
      "journal": "The American journal of physiology",
      "authors": "Homer et al.",
      "author_search": "homer homer",
      "doi": "10.1152/ajpregu.1983.245.4.r534",
      "doi_url": "https://doi.org/10.1152/ajpregu.1983.245.4.r534",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6624949/",
      "url": "https://h2medizin.org/studien/studie-homer-1983-transiente-loesungen-gleichungen-den/",
      "methods": [
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      "h2category": "preclinical"
    },
    {
      "pmid": "6223807",
      "year": 1983,
      "title": "Laparoskopische Messung des pankreatischen Blutflusses.",
      "title_en": "Laparoscopic measurement of pancreatic blood flow.",
      "title_de": null,
      "journal": "Endoscopy",
      "authors": "Ishida et al.",
      "author_search": "ishida ishida",
      "doi": "10.1055/s-2007-1021480",
      "doi_url": "https://doi.org/10.1055/s-2007-1021480",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6223807/",
      "url": "https://h2medizin.org/studien/studie-ishida-1983-laparoskopische-messung-des-pankreatischen/",
      "methods": [],
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    {
      "pmid": "6855267",
      "year": 1983,
      "title": "Die Fettsäure-Acylketten-Zusammensetzung normaler und leukämischer menschlicher Lymphozyten und ihre Modulation durch spezialisierte Hydrierung.",
      "title_en": "The fatty acyl chain composition of human normal and leukaemic lymphocytes and its modulation by specialised hydrogenation.",
      "title_de": null,
      "journal": "Leukemia research",
      "authors": "Peel et al.",
      "author_search": "peel peel",
      "doi": "10.1016/0145-2126(83)90009-7",
      "doi_url": "https://doi.org/10.1016/0145-2126(83)90009-7",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6855267/",
      "url": "https://h2medizin.org/studien/studie-peel-1983-fettsaeure-acylketten-zusammensetzung-normaler/",
      "methods": [
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    {
      "pmid": "6620060",
      "year": 1983,
      "title": "Atemwasserstoff-Analyse: eine Übersichtsarbeit zu den Methodiken und klinischen Anwendungen.",
      "title_en": "Breath hydrogen analysis: a review of the methodologies and clinical applications.",
      "title_de": null,
      "journal": "Journal of pediatric gastroenterology and nutrition",
      "authors": "Ostrander et al.",
      "author_search": "ostrander ostrander",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/6620060/",
      "url": "https://h2medizin.org/studien/studie-ostrander-1983-atemwasserstoff-analyse-uebersichtsarbeit-den/",
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      "human": false,
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      "h2category": "review"
    },
    {
      "pmid": "7054042",
      "year": 1982,
      "title": "Kontaktelektroden-Methode in der Wasserstoffgas-Clearance-Technik: eine neue Methode zur Bestimmung des regionalen Magenmukosa-Blutflusses bei Tieren und Menschen.",
      "title_en": "Contact electrode method in hydrogen gas clearance technique: a new method for determination of regional gastric mucosal blood flow in animals and humans.",
      "title_de": null,
      "journal": "Gastroenterology",
      "authors": "Murakami et al.",
      "author_search": "murakami murakami",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/7054042/",
      "url": "https://h2medizin.org/studien/studie-murakami-1982-kontaktelektroden-methode-wasserstoffgas-clearance/",
      "methods": [
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      "human": false,
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      "h2category": "preclinical"
    },
    {
      "pmid": "10317",
      "year": 1976,
      "title": "Charakterisierung von Bacteroides melaninogenicus.",
      "title_en": "Characterization of bacteroides melaninogenicus.",
      "title_de": null,
      "journal": "Journal of clinical microbiology",
      "authors": "Harding et al.",
      "author_search": "harding harding",
      "doi": "10.1128/jcm.4.4.354-359.1976",
      "doi_url": "https://doi.org/10.1128/jcm.4.4.354-359.1976",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/10317/",
      "url": "https://h2medizin.org/studien/studie-harding-1976-charakterisierung-bacteroides-melaninogenicus/",
      "methods": [
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    {
      "pmid": "5009552",
      "year": 1972,
      "title": "Messungen des fokalen intrazerebralen Blutflusses um Tiefenelektroden beim Menschen mit Wasserstoffgas.",
      "title_en": "Measurements in man of focal intracerebral blood flow around depth-electrodes with hydrogen gas.",
      "title_de": null,
      "journal": "Progress in brain research",
      "authors": "Sem-Jacobsen et al.",
      "author_search": "sem-jacobsen sem-jacobsen",
      "doi": "10.1016/s0079-6123(08)60090-4",
      "doi_url": "https://doi.org/10.1016/s0079-6123(08)60090-4",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/5009552/",
      "url": "https://h2medizin.org/studien/studie-semjacobsen-1972-messungen-des-fokalen-intrazerebralen/",
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      "h2category": "tracer-clearance"
    },
    {
      "pmid": "5790483",
      "year": 1969,
      "title": "Produktion und Ausscheidung von Wasserstoffgas beim Menschen.",
      "title_en": "Production and excretion of hydrogen gas in man.",
      "title_de": null,
      "journal": "The New England journal of medicine",
      "authors": "Levitt",
      "author_search": "levitt levitt",
      "doi": "10.1056/nejm196907172810303",
      "doi_url": "https://doi.org/10.1056/nejm196907172810303",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/5790483/",
      "url": "https://h2medizin.org/studien/studie-levitt-1969-produktion-ausscheidung-wasserstoffgas-beim/",
      "methods": [],
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      "h2category": "byproduct"
    },
    {
      "pmid": "4889689",
      "year": 1969,
      "title": "Wasserstoffinhalationskurven in der kardiologischen Diagnostik bei Kindern.",
      "title_en": "[Hydrogen inhalation curves in cardiologic diagnosis of children].",
      "title_de": null,
      "journal": "Nederlands tijdschrift voor geneeskunde",
      "authors": "Muller et al.",
      "author_search": "muller muller",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/4889689/",
      "url": "https://h2medizin.org/studien/studie-muller-1969-wasserstoffinhalationskurven-kardiologischen-diagnostik-kindern/",
      "methods": [],
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    },
    {
      "pmid": "5378111",
      "year": 1969,
      "title": "Messung des Blutflusses der menschlichen Cervix uteri mittels lokaler Wasserstoffgas-Clearance.",
      "title_en": "Measurement of human uterine cervical blood flow by local hydrogen gas clearance.",
      "title_de": null,
      "journal": "Acta obstetricia et gynecologica Scandinavica",
      "authors": "Klingenberg et al.",
      "author_search": "klingenberg klingenberg",
      "doi": "10.3109/00016346909156661",
      "doi_url": "https://doi.org/10.3109/00016346909156661",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/5378111/",
      "url": "https://h2medizin.org/studien/studie-klingenberg-1969-messung-des-blutflusses-menschlichen/",
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    },
    {
      "pmid": "5856743",
      "year": 1965,
      "title": "Die Anwendung der Wasserstoffinhalation beim Nachweis intrakardialer Shunts.",
      "title_en": "The use of hydrogen inhalation in the detection of intrcardiac shunts.",
      "title_de": null,
      "journal": "South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde",
      "authors": "Heimann et al.",
      "author_search": "heimann heimann",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/5856743/",
      "url": "https://h2medizin.org/studien/studie-heimann-1965-anwendung-wasserstoffinhalation-beim-nachweis/",
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    },
    {
      "pmid": "5294201",
      "year": 1965,
      "title": "Nachweis minimaler Links-Rechts-Shunts durch Wasserstoffinhalation.",
      "title_en": "[Detection of minimal left-right shunts by hydrogen inhalation].",
      "title_de": null,
      "journal": "Acta cardiologica",
      "authors": "Cosyns et al.",
      "author_search": "cosyns cosyns",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/5294201/",
      "url": "https://h2medizin.org/studien/studie-cosyns-1965-nachweis-minimaler-links-rechts/",
      "methods": [],
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      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "14068764",
      "year": 1963,
      "title": "Der klinische Nutzen von Wasserstoffgas als Indikator für Links-Rechts-Shunts.",
      "title_en": "THE CLINICAL USEFULNESS OF HYDROGEN GAS AS AN INDICATOR OF LEFT-TO-RIGHT SHUNTS.",
      "title_de": null,
      "journal": "Circulation",
      "authors": "HUGENHOLTZ et al.",
      "author_search": "hugenholtz hugenholtz",
      "doi": "10.1161/01.cir.28.4.542",
      "doi_url": "https://doi.org/10.1161/01.cir.28.4.542",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/14068764/",
      "url": "https://h2medizin.org/studien/studie-hugenholtz-1963-klinische-nutzen-wasserstoffgas-indikator/",
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      "h2category": "tracer-clearance"
    },
    {
      "pmid": "13810467",
      "year": 1959,
      "title": "Nachweis von Links-Rechts-Shunts mittels einer intravaskulären Elektrode mit Wasserstoff als Indikator.",
      "title_en": "Left-to-right shunt detection by an intravascular electrode with hydrogen as an indicator.",
      "title_de": null,
      "journal": "Science (New York, N.Y.)",
      "authors": "CLARK LC Jr et al.",
      "author_search": "clark lc jr clark lc jr",
      "doi": "10.1126/science.130.3377.709",
      "doi_url": "https://doi.org/10.1126/science.130.3377.709",
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/13810467/",
      "url": "https://h2medizin.org/studien/studie-clarklcjr-1959-nachweis-links-rechts-shunts/",
      "methods": [],
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        "respiratory"
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      "human": true,
      "therapeutic": false,
      "h2category": "tracer-clearance"
    },
    {
      "pmid": "20287912",
      "year": 1947,
      "title": "Über die Aktivierung von molekularem Wasserstoff durch Proteus vulgaris.",
      "title_en": "On the activation of molecular hydrogen by Proteus vulgaris.",
      "title_de": null,
      "journal": "The Journal of biological chemistry",
      "authors": "FARKAS et al.",
      "author_search": "farkas farkas",
      "doi": null,
      "doi_url": null,
      "pubmed": "https://pubmed.ncbi.nlm.nih.gov/20287912/",
      "url": "https://h2medizin.org/studien/studie-farkas-1947-aktivierung-proteus-vulgaris/",
      "methods": [
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}
